The in vivo differential diagnosis between idiopathic Parkinson's disease (PD) and atypical parkinsonian syndromes (PS), such as multiple system atrophy [MSA with a cerebellar (C) and parkinsonian (P) subtype] and progressive supranuclear palsy - Richardson's Syndrome (PSP-RS) is often challenging. Previous brain MR proton spectroscopy ((1)H-MRS) studies showed biochemical alterations in PS, despite results are conflicting. Cerebellum plays a central role in motor control and its alterations has been already demonstrated in atypical PS. The main aim of this study was to evaluate diagnostic accuracy of cerebellar (1)H-MRS in the differential diagnosis between PD and atypical PS.

Zanigni, S., Testa, C., Calandra-Buonaura, G., Sambati, L., Guarino, M., Gabellini, A., et al. (2015). The contribution of cerebellar proton magnetic resonance spectroscopy in the differential diagnosis among parkinsonian syndromes. PARKINSONISM & RELATED DISORDERS, 21(8), 929-937 [10.1016/j.parkreldis.2015.05.025].

The contribution of cerebellar proton magnetic resonance spectroscopy in the differential diagnosis among parkinsonian syndromes

ZANIGNI, STEFANO;TESTA, CLAUDIA;CALANDRA BUONAURA, GIOVANNA;EVANGELISTI, STEFANIA;CORTELLI, PIETRO;LODI, RAFFAELE;TONON, CATERINA;SAMBATI, LUISA
2015

Abstract

The in vivo differential diagnosis between idiopathic Parkinson's disease (PD) and atypical parkinsonian syndromes (PS), such as multiple system atrophy [MSA with a cerebellar (C) and parkinsonian (P) subtype] and progressive supranuclear palsy - Richardson's Syndrome (PSP-RS) is often challenging. Previous brain MR proton spectroscopy ((1)H-MRS) studies showed biochemical alterations in PS, despite results are conflicting. Cerebellum plays a central role in motor control and its alterations has been already demonstrated in atypical PS. The main aim of this study was to evaluate diagnostic accuracy of cerebellar (1)H-MRS in the differential diagnosis between PD and atypical PS.
2015
Zanigni, S., Testa, C., Calandra-Buonaura, G., Sambati, L., Guarino, M., Gabellini, A., et al. (2015). The contribution of cerebellar proton magnetic resonance spectroscopy in the differential diagnosis among parkinsonian syndromes. PARKINSONISM & RELATED DISORDERS, 21(8), 929-937 [10.1016/j.parkreldis.2015.05.025].
Zanigni, S.; Testa, C.; Calandra-Buonaura, G.; Sambati, L.; Guarino, M.; Gabellini, A.; Evangelisti, S.; Cortelli, P.; Lodi, R.; Tonon, C.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11585/515582
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