Ten benzimidazole-4,7-diones were synthesized and tested in vitro on two tumor cell lines. Several compounds showed a significant antiproliferative activity on K562 cells, although to a different extent, whereas compound 1i showed a highly significant activity on SW620 cells, comparable to that of doxorubicin. Both the substituents in the quinone ring and the position of the nitrogen atom in the pyridine moiety play a crucial role for the biological activity.
Differential antiproliferative activity of new benzimidazole- 4,7-diones / L. Garuti; M. Roberti; D. Pizzirani; A. Pession; E. Leoncini; V. Cenci; S. Hrelia.. - In: IL FARMACO. - ISSN 0014-827X. - STAMPA. - 59:(2004), pp. 663-668. [10.1016/j.farmac.2004.04.001]
Differential antiproliferative activity of new benzimidazole- 4,7-diones.
GARUTI, LAURA;ROBERTI, MARINELLA;PIZZIRANI, DANIELA;PESSION, ANNALISA;LEONCINI, EMANUELA;CENCI, VALENTINA;HRELIA, SILVANA
2004
Abstract
Ten benzimidazole-4,7-diones were synthesized and tested in vitro on two tumor cell lines. Several compounds showed a significant antiproliferative activity on K562 cells, although to a different extent, whereas compound 1i showed a highly significant activity on SW620 cells, comparable to that of doxorubicin. Both the substituents in the quinone ring and the position of the nitrogen atom in the pyridine moiety play a crucial role for the biological activity.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
