Ten benzimidazole-4,7-diones were synthesized and tested in vitro on two tumor cell lines. Several compounds showed a significant antiproliferative activity on K562 cells, although to a different extent, whereas compound 1i showed a highly significant activity on SW620 cells, comparable to that of doxorubicin. Both the substituents in the quinone ring and the position of the nitrogen atom in the pyridine moiety play a crucial role for the biological activity.

Differential antiproliferative activity of new benzimidazole- 4,7-diones.

GARUTI, LAURA;ROBERTI, MARINELLA;PIZZIRANI, DANIELA;PESSION, ANNALISA;LEONCINI, EMANUELA;CENCI, VALENTINA;HRELIA, SILVANA
2004

Abstract

Ten benzimidazole-4,7-diones were synthesized and tested in vitro on two tumor cell lines. Several compounds showed a significant antiproliferative activity on K562 cells, although to a different extent, whereas compound 1i showed a highly significant activity on SW620 cells, comparable to that of doxorubicin. Both the substituents in the quinone ring and the position of the nitrogen atom in the pyridine moiety play a crucial role for the biological activity.
L. Garuti; M. Roberti; D. Pizzirani; A. Pession; E. Leoncini; V. Cenci; S. Hrelia.
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11585/4226
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