Ten benzimidazole-4,7-diones were synthesized and tested in vitro on two tumor cell lines. Several compounds showed a significant antiproliferative activity on K562 cells, although to a different extent, whereas compound 1i showed a highly significant activity on SW620 cells, comparable to that of doxorubicin. Both the substituents in the quinone ring and the position of the nitrogen atom in the pyridine moiety play a crucial role for the biological activity.
L. Garuti, M. Roberti, D. Pizzirani, A. Pession, E. Leoncini, V. Cenci, et al. (2004). Differential antiproliferative activity of new benzimidazole- 4,7-diones. IL FARMACO, 59, 663-668 [10.1016/j.farmac.2004.04.001].
Differential antiproliferative activity of new benzimidazole- 4,7-diones.
GARUTI, LAURA;ROBERTI, MARINELLA;PIZZIRANI, DANIELA;PESSION, ANNALISA;LEONCINI, EMANUELA;CENCI, VALENTINA;HRELIA, SILVANA
2004
Abstract
Ten benzimidazole-4,7-diones were synthesized and tested in vitro on two tumor cell lines. Several compounds showed a significant antiproliferative activity on K562 cells, although to a different extent, whereas compound 1i showed a highly significant activity on SW620 cells, comparable to that of doxorubicin. Both the substituents in the quinone ring and the position of the nitrogen atom in the pyridine moiety play a crucial role for the biological activity.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
