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EnglishTen benzimidazole-4,7-diones were synthesized and tested in vitro on two tumor cell lines. Several compounds showed a significant antiproliferative activity on K562 cells, although to a different extent, whereas compound 1i showed a highly significant activity on SW620 cells, comparable to that of doxorubicin. Both the substituents in the quinone ring and the position of the nitrogen atom in the pyridine moiety play a crucial role for the biological activity.
| Titolo: | Differential antiproliferative activity of new benzimidazole- 4,7-diones. |
| Autore/i: | GARUTI, LAURA; ROBERTI, MARINELLA; PIZZIRANI, DANIELA; PESSION, ANNALISA; LEONCINI, EMANUELA; CENCI, VALENTINA; HRELIA, SILVANA |
| Autore/i Unibo: | |
| Anno: | 2004 |
| Rivista: | |
| Digital Object Identifier (DOI): | http://dx.doi.org/10.1016/j.farmac.2004.04.001 |
| Abstract: | Ten benzimidazole-4,7-diones were synthesized and tested in vitro on two tumor cell lines. Several compounds showed a significant antiproliferative activity on K562 cells, although to a different extent, whereas compound 1i showed a highly significant activity on SW620 cells, comparable to that of doxorubicin. Both the substituents in the quinone ring and the position of the nitrogen atom in the pyridine moiety play a crucial role for the biological activity. |
| Data prodotto definitivo in UGOV: | 2005-10-10 |
| Appare nelle tipologie: | 1.01 Articolo in rivista |
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http://hdl.handle.net/11585/4226
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