ROBERTI, MARINELLA
ROBERTI, MARINELLA
FABIT - DIPARTIMENTO DI FARMACIA E BIOTECNOLOGIE
Docenti di ruolo di IIa fascia
Investigating synthetic lethality and PARP inhibitor resistance in pancreatic cancer through enantiomer differential activity
2025 Masi, Mirco; Poppi, Laura; Previtali, Viola; Nelson, Shannon R; Wynne, Kieran; Varignani, Giulia; Falchi, Federico; Veronesi, Marina; Albanesi, Ennio; Tedesco, Daniele; De Franco, Francesca; Ciamarone, Andrea; Myers, Samuel H; Ortega, Jose Antonio; Bagnolini, Greta; Ferrandi, Giovanni; Farabegoli, Fulvia; Tirelli, Nicola; Di Stefano, Giuseppina; Oliviero, Giorgio; Walsh, Naomi; Roberti, Marinella; Girotto, Stefania; Cavalli, Andrea
A journey through targeting BRCA2-RAD51 protein-protein interaction to establish synthetic lethality as paradigm for anticancer drug discovery
2024 Bagnolini G., Poppi L., Previtali V., Ferrandi G., Rinaldi F., Girotto S., Hirsch A.K.H., Roberti M., Cavalli A.
Design and synthesis of RAD51-BRCA2 disruptors to inhibit homologous recombination and achieve synthetic lethality in pancreatic cancer cells
2024 Ferrandi, Giovanni; Poppi, Laura; Bagnolini, Greta; Previtali, Viola; Roberti, Marinella; Cavalli, Andrea
Design and synthesis of RAD51-BRCA2 protein-protein interaction disruptors to trigger synthetic lethality with Olaparib in pancreatic cancer cells
2024 Ferrandi, Giovanni; Poppi, Laura; Bagnolini, Greta; Falchi, Federico; Previtali, Viola; Girotto, Stefania; Roberti, Marinella; Cavalli, Andrea
Differential enantiomers activity of ARN24089 to achieve synthetic lethality in pancreatic cancer
2024 Previtali, Viola; Masi, Mirco; Poppi, Laura; Varignani, Giulia; Falchi, Federico; Tedesco, Daniele; Wynne, Kieran; Oliviero, Giorgio; Bagnolini, Greta; Farabegoli, Fulvia; DI STEFANO, Giuseppina; Girotto, Stefania; Roberti, Marinella; Cavalli, Andrea
New Horizons of Synthetic Lethality in Cancer: Current Development and Future Perspectives
2024 Previtali, Viola; Bagnolini, Greta; Ciamarone, Andrea; Ferrandi, Giovanni; Rinaldi, Francesco; Myers, Samuel Harry; Roberti, Marinella; Cavalli, Andrea
Targeting RNA degradation with small molecules: design and synthesis of selective RNA binders and development of ribonuclease targeting chimeras (RIBOTACs)
2024 Sdei, Federico; Bagnolini, Greta; Falchi, Federico; Ghezzo, M.; Sosic, Alice; Sissi, Claudia; Roberti, Marinella; Bolognesi, MARIA LAURA
A RAD51/BRCA2 small molecule inhibitor enhances the antineoplastic effect of the PARPi talazoparib in pancreatic cancer
2023 Laura Poppi, Samuel H Myers, Viola Previtali, Francesco Rinaldi, Fulvia Farabegoli, Giuseppina Di Stefano, Naomi Walsh, Marinella Roberti, Andrea Cavalli
An 19F NMR fragment-based approach for the discovery and development of BRCA2-RAD51 inhibitors to pursuit synthetic lethality in combination with PARP inhibition in pancreatic cancer
2023 Myers, S. H.; Poppi, L.; Rinaldi, F.; Veronesi, M.; Ciamarone, A.; Previtali, V.; Bagnolini, G.; Schipani, F.; Ortega Martínez, J. A.; Girotto, S.; Di Stefano, G.; Farabegoli, F.; Walsh, N.; De Franco, F.; Roberti, M.; Cavalli, A.
Application of an “inhalation by design” approach to the identification and in-vitro evaluation of novel purine based PI3Kδ inhibitors
2023 Mazzucato, R.; Roberti, M.; Capelli, A. M.; Rancati, F.; Biagetti, M.; Fiorelli, C.; Bruno, P.; Ronchi, P.; Bertolini, S.; Corsi, M.; Pala, D.
Design and synthesis of RAD51-BRCA disruptors to inhibit homologous recombination and achieve synthetic lethality in cancer cells
2023 Ferrandi, Giovanni; Bagnolini, Greta; Roberti, Marinella; Cavalli, Andrea
Innovative Strategy toward Mutant CFTR Rescue in Cystic Fibrosis: Design and Synthesis of Thiadiazole Inhibitors of the E3 Ligase RNF5
2023 Brusa, Irene; Sondo, Elvira; Pesce, Emanuela; Tomati, Valeria; Gioia, Dario; Falchi, Federico; Balboni, Beatrice; Ortega Martínez, Jose Antonio; Veronesi, Marina; Romeo, Elisa; Margaroli, Natasha; Recanatini, Maurizio; Girotto, Stefania; Pedemonte, Nicoletta; Roberti, Marinella; Cavalli, Andrea
Preomic profile of BxPC-3 cells after treatment with BRC4
2023 Previtali V.; Myers S.H.; Poppi L.; Wynne K.; Casamassima I.; Girotto S.; Di Stefano G.; Farabegoli F.; Roberti M.; Oliviero G.; Cavalli A.
Proteomic profile of BxPC-3 cells after treatment with BRC4
2023 Viola Previtali, Samuel H. Myers, Laura Poppi, Kieran Wynne, Irene Casamassima Stefania Girotto, Giuseppina Di Stefano, Fulvia Farabegoli, Marinella Roberti, Giorgio Oliviero, Andrea Cavalli
Triggering RNA degradation with small molecules: development of RIBOnuclease TArgeting Chimeras (RIBOTACs)
2023 Bagnolini, G.; Falchi, F.; Sdei, F.; Roberti, M.; Sosic, A.; Sissi, C.; Bolognesi, M. L.
Enriching Proteolysis Targeting Chimeras with a Second Modality: When Two Are Better Than One
2022 Salerno, Alessandra; Seghetti, Francesca; Caciolla, Jessica; Uliassi, Elisa; Testi, Eleonora; Guardigni, Melissa; Roberti, Marinella; Milelli, Andrea; Bolognesi, Maria Laura
Identification and subsequent development of RAD51-BRCA2 disruptors through a fragment-based approach
2022 Samuel Harry Myers , Viola Previtali, Laura Poppi, Francesco Rinaldi, Fabrizio Schipani, Jose Antonio Ortega, Francesca De Franco, Marina Veronesi, Roberto Pellicciari, Marinella Roberti, Stefania Girotto, Giuseppina Di Stefano, Andrea Cavalli
Identification of RAD51-BRCA2 inhibitors using N-acylhydrazone-based dynamic combinatorial chemistry
2022 Bagnolini, Greta; Balboni, Beatrice; Schipani, Fabrizio; Gioia, Dario; Veronesi, Marina; De Franco, Francesca; Kaya, Cansu; Jumde, Ravindra P.; Antonio Ortega, Jose; Girotto, Stefania; Hirsch, Anna K. H.; Roberti, Marinella; Cavalli, Andrea
Identification of RAD51-BRCA2 Inhibitors Using N-Acylhydrazone-Based Dynamic Combinatorial Chemistry
2022 Bagnolini, G.; Balboni, B.; Schipani, F.; Gioia, D.; Veronesi, M.; De Franco, F.; Kaya, C.; Jumde, R. P.; Ortega, J. A.; Girotto, S.; Hirsch, A. K. H.; Roberti, M.; Cavalli, A.
Insights into the activity of ARN24089, a new RAD51-BRCA2 disruptor that inhibits homologous recombination and achieves synthetic lethality in pancreatic cancer
2022 Previtali V., Myers S. H., Bagnolini G., Poppi L., Rinaldi F., Schipani F., Ortega J. A., De Franco F., Pellicciari R., Girotto S., Oliviero G., Walsh N., Valenti G., Tirelli N., Di Stefano G., Roberti M., Cavalli A.
| Titolo | Autore(i) | Anno | Periodico | Editore | Tipo | File |
|---|---|---|---|---|---|---|
| Investigating synthetic lethality and PARP inhibitor resistance in pancreatic cancer through enantiomer differential activity | Masi, Mirco; Poppi, Laura; Previtali, Viola; Nelson, Shannon R; Wynne, Kieran; Varignani, Giulia;... Falchi, Federico; Veronesi, Marina; Albanesi, Ennio; Tedesco, Daniele; De Franco, Francesca; Ciamarone, Andrea; Myers, Samuel H; Ortega, Jose Antonio; Bagnolini, Greta; Ferrandi, Giovanni; Farabegoli, Fulvia; Tirelli, Nicola; Di Stefano, Giuseppina; Oliviero, Giorgio; Walsh, Naomi; Roberti, Marinella; Girotto, Stefania; Cavalli, Andrea | 2025-01-01 | CELL DEATH DISCOVERY | - | 1.01 Articolo in rivista | Masi_et_al-2025-Cell_Death_Discovery.pdf; 41420_2025_2382_MOESM3_ESM.xlsx; 41420_2025_2382_MOESM2_ESM.pdf; 41420_2025_2382_MOESM1_ESM.docx |
| A journey through targeting BRCA2-RAD51 protein-protein interaction to establish synthetic lethality as paradigm for anticancer drug discovery | Bagnolini G., Poppi L., Previtali V., Ferrandi G., Rinaldi F., Girotto S., Hirsch A.K.H., Roberti... M., Cavalli A. | 2024-01-01 | - | - | 4.01 Contributo in Atti di convegno | - |
| Design and synthesis of RAD51-BRCA2 disruptors to inhibit homologous recombination and achieve synthetic lethality in pancreatic cancer cells | Ferrandi, Giovanni; Poppi, Laura; Bagnolini, Greta; Previtali, Viola; Roberti, Marinella; Cavalli..., Andrea | 2024-01-01 | - | - | 4.03 Poster | - |
| Design and synthesis of RAD51-BRCA2 protein-protein interaction disruptors to trigger synthetic lethality with Olaparib in pancreatic cancer cells | Ferrandi, Giovanni; Poppi, Laura; Bagnolini, Greta; Falchi, Federico; Previtali, Viola; Girotto, ...Stefania; Roberti, Marinella; Cavalli, Andrea | 2024-01-01 | - | - | 4.03 Poster | - |
| Differential enantiomers activity of ARN24089 to achieve synthetic lethality in pancreatic cancer | Previtali, Viola; Masi, Mirco; Poppi, Laura; Varignani, Giulia; Falchi, Federico; Tedesco, Daniel...e; Wynne, Kieran; Oliviero, Giorgio; Bagnolini, Greta; Farabegoli, Fulvia; DI STEFANO, Giuseppina; Girotto, Stefania; Roberti, Marinella; Cavalli, Andrea | 2024-01-01 | - | - | 4.03 Poster | - |
| New Horizons of Synthetic Lethality in Cancer: Current Development and Future Perspectives | Previtali, Viola; Bagnolini, Greta; Ciamarone, Andrea; Ferrandi, Giovanni; Rinaldi, Francesco; My...ers, Samuel Harry; Roberti, Marinella; Cavalli, Andrea | 2024-01-01 | JOURNAL OF MEDICINAL CHEMISTRY | - | 1.01 Articolo in rivista | New Horizons of Synthetic Lethality in Cancer_ Current Development and Future Perspectives.pdf |
| Targeting RNA degradation with small molecules: design and synthesis of selective RNA binders and development of ribonuclease targeting chimeras (RIBOTACs) | Sdei, Federico; Bagnolini, Greta; Falchi, Federico; Ghezzo, M.; Sosic, Alice; Sissi, Claudia; Rob...erti, Marinella; Bolognesi, MARIA LAURA | 2024-01-01 | - | - | 4.03 Poster | - |
| A RAD51/BRCA2 small molecule inhibitor enhances the antineoplastic effect of the PARPi talazoparib in pancreatic cancer | Laura Poppi, Samuel H Myers, Viola Previtali, Francesco Rinaldi, Fulvia Farabegoli, Giuseppina Di... Stefano, Naomi Walsh, Marinella Roberti, Andrea Cavalli | 2023-01-01 | - | FEBS PRESS | 4.03 Poster | - |
| An 19F NMR fragment-based approach for the discovery and development of BRCA2-RAD51 inhibitors to pursuit synthetic lethality in combination with PARP inhibition in pancreatic cancer | Myers, S. H.; Poppi, L.; Rinaldi, F.; Veronesi, M.; Ciamarone, A.; Previtali, V.; Bagnolini, G.; ...Schipani, F.; Ortega Martínez, J. A.; Girotto, S.; Di Stefano, G.; Farabegoli, F.; Walsh, N.; De Franco, F.; Roberti, M.; Cavalli, A. | 2023-01-01 | EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | - | 1.01 Articolo in rivista | 1-s2.0-S0223523423010814-mmc1.docx; 1-s2.0-S0223523423010814-main.pdf |
| Application of an “inhalation by design” approach to the identification and in-vitro evaluation of novel purine based PI3Kδ inhibitors | Mazzucato, R.; Roberti, M.; Capelli, A. M.; Rancati, F.; Biagetti, M.; Fiorelli, C.; Bruno, P.; R...onchi, P.; Bertolini, S.; Corsi, M.; Pala, D. | 2023-01-01 | EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | - | 1.01 Articolo in rivista | 2023_03_29_RevisedManuscript_EJMC.docx; Supplementary information.docx |
| Design and synthesis of RAD51-BRCA disruptors to inhibit homologous recombination and achieve synthetic lethality in cancer cells | Ferrandi, Giovanni; Bagnolini, Greta; Roberti, Marinella; Cavalli, Andrea | 2023-01-01 | - | - | 4.03 Poster | - |
| Innovative Strategy toward Mutant CFTR Rescue in Cystic Fibrosis: Design and Synthesis of Thiadiazole Inhibitors of the E3 Ligase RNF5 | Brusa, Irene; Sondo, Elvira; Pesce, Emanuela; Tomati, Valeria; Gioia, Dario; Falchi, Federico; Ba...lboni, Beatrice; Ortega Martínez, Jose Antonio; Veronesi, Marina; Romeo, Elisa; Margaroli, Natasha; Recanatini, Maurizio; Girotto, Stefania; Pedemonte, Nicoletta; Roberti, Marinella; Cavalli, Andrea | 2023-01-01 | JOURNAL OF MEDICINAL CHEMISTRY | - | 1.01 Articolo in rivista | brusa-et-al-2023-innovative-strategy-toward-mutant-cftr-rescue-in-cystic-fibrosis-design-and-synthesis-of-thiadiazole.pdf |
| Preomic profile of BxPC-3 cells after treatment with BRC4 | Previtali V.; Myers S.H.; Poppi L.; Wynne K.; Casamassima I.; Girotto S.; Di Stefano G.; Farabego...li F.; Roberti M.; Oliviero G.; Cavalli A. | 2023-01-01 | JOURNAL OF PROTEOMICS | - | 1.01 Articolo in rivista | manuscript_jprot_revised_second round_clean (1).docx |
| Proteomic profile of BxPC-3 cells after treatment with BRC4 | Viola Previtali, Samuel H. Myers, Laura Poppi, Kieran Wynne, Irene Casamassima Stefania Girotto, ...Giuseppina Di Stefano, Fulvia Farabegoli, Marinella Roberti, Giorgio Oliviero, Andrea Cavalli | 2023-01-01 | JOURNAL OF PROTEOMICS | - | 1.01 Articolo in rivista | - |
| Triggering RNA degradation with small molecules: development of RIBOnuclease TArgeting Chimeras (RIBOTACs) | Bagnolini, G.; Falchi, F.; Sdei, F.; Roberti, M.; Sosic, A.; Sissi, C.; Bolognesi, M. L. | 2023-01-01 | - | - | 4.03 Poster | - |
| Enriching Proteolysis Targeting Chimeras with a Second Modality: When Two Are Better Than One | Salerno, Alessandra; Seghetti, Francesca; Caciolla, Jessica; Uliassi, Elisa; Testi, Eleonora; Gua...rdigni, Melissa; Roberti, Marinella; Milelli, Andrea; Bolognesi, Maria Laura | 2022-01-01 | JOURNAL OF MEDICINAL CHEMISTRY | - | 1.01 Articolo in rivista | acs.jmedchem.2c00302.pdf |
| Identification and subsequent development of RAD51-BRCA2 disruptors through a fragment-based approach | Samuel Harry Myers , Viola Previtali, Laura Poppi, Francesco Rinaldi, Fabrizio Schipani, Jose Ant...onio Ortega, Francesca De Franco, Marina Veronesi, Roberto Pellicciari, Marinella Roberti, Stefania Girotto, Giuseppina Di Stefano, Andrea Cavalli | 2022-01-01 | - | - | 4.02 Riassunto (Abstract) | - |
| Identification of RAD51-BRCA2 inhibitors using N-acylhydrazone-based dynamic combinatorial chemistry | Bagnolini, Greta; Balboni, Beatrice; Schipani, Fabrizio; Gioia, Dario; Veronesi, Marina; De Franc...o, Francesca; Kaya, Cansu; Jumde, Ravindra P.; Antonio Ortega, Jose; Girotto, Stefania; Hirsch, Anna K. H.; Roberti, Marinella; Cavalli, Andrea | 2022-01-01 | - | - | 4.01 Contributo in Atti di convegno | - |
| Identification of RAD51-BRCA2 Inhibitors Using N-Acylhydrazone-Based Dynamic Combinatorial Chemistry | Bagnolini, G.; Balboni, B.; Schipani, F.; Gioia, D.; Veronesi, M.; De Franco, F.; Kaya, C.; Jumde..., R. P.; Ortega, J. A.; Girotto, S.; Hirsch, A. K. H.; Roberti, M.; Cavalli, A. | 2022-01-01 | ACS MEDICINAL CHEMISTRY LETTERS | - | 1.01 Articolo in rivista | acsmedchemlett._2022.pdf |
| Insights into the activity of ARN24089, a new RAD51-BRCA2 disruptor that inhibits homologous recombination and achieves synthetic lethality in pancreatic cancer | Previtali V., Myers S. H., Bagnolini G., Poppi L., Rinaldi F., Schipani F., Ortega J. A., De Fran...co F., Pellicciari R., Girotto S., Oliviero G., Walsh N., Valenti G., Tirelli N., Di Stefano G., Roberti M., Cavalli A. | 2022-01-01 | - | - | 4.02 Riassunto (Abstract) | - |