ROBERTI, MARINELLA
ROBERTI, MARINELLA
DIPARTIMENTO DI FARMACIA E BIOTECNOLOGIE
Docenti di ruolo di IIa fascia
A journey through targeting BRCA2-RAD51 protein-protein interaction to establish synthetic lethality as paradigm for anticancer drug discovery
2024 Bagnolini G., Poppi L., Previtali V., Ferrandi G., Rinaldi F., Girotto S., Hirsch A.K.H., Roberti M., Cavalli A.
New Horizons of Synthetic Lethality in Cancer: Current Development and Future Perspectives
2024 Previtali, Viola; Bagnolini, Greta; Ciamarone, Andrea; Ferrandi, Giovanni; Rinaldi, Francesco; Myers, Samuel Harry; Roberti, Marinella; Cavalli, Andrea
A RAD51/BRCA2 small molecule inhibitor enhances the antineoplastic effect of the PARPi talazoparib in pancreatic cancer
2023 Laura Poppi, Samuel H Myers, Viola Previtali, Francesco Rinaldi, Fulvia Farabegoli, Giuseppina Di Stefano, Naomi Walsh, Marinella Roberti, Andrea Cavalli
An 19F NMR fragment-based approach for the discovery and development of BRCA2-RAD51 inhibitors to pursuit synthetic lethality in combination with PARP inhibition in pancreatic cancer
2023 Myers S. H., Poppi L., Rinaldi F., Veronesi M., Ciamarone A., Previtali V., Bagnolini G., Schipani F., Ortega Martínez J. A., Girotto S., Di Stefano G., Farabegoli F., Walsh N., De Franco F., Roberti M., Cavalli A.
Application of an “inhalation by design” approach to the identification and in-vitro evaluation of novel purine based PI3Kδ inhibitors
2023 Mazzucato R.; Roberti M.; Capelli A.M.; Rancati F.; Biagetti M.; Fiorelli C.; Bruno P.; Ronchi P.; Bertolini S.; Corsi M.; Pala D.
Innovative Strategy toward Mutant CFTR Rescue in Cystic Fibrosis: Design and Synthesis of Thiadiazole Inhibitors of the E3 Ligase RNF5
2023 Brusa, Irene; Sondo, Elvira; Pesce, Emanuela; Tomati, Valeria; Gioia, Dario; Falchi, Federico; Balboni, Beatrice; Ortega Martínez, Jose Antonio; Veronesi, Marina; Romeo, Elisa; Margaroli, Natasha; Recanatini, Maurizio; Girotto, Stefania; Pedemonte, Nicoletta; Roberti, Marinella; Cavalli, Andrea
Preomic profile of BxPC-3 cells after treatment with BRC4
2023 Previtali V.; Myers S.H.; Poppi L.; Wynne K.; Casamassima I.; Girotto S.; Di Stefano G.; Farabegoli F.; Roberti M.; Oliviero G.; Cavalli A.
Proteomic profile of BxPC-3 cells after treatment with BRC4
2023 Viola Previtali, Samuel H. Myers, Laura Poppi, Kieran Wynne, Irene Casamassima Stefania Girotto, Giuseppina Di Stefano, Fulvia Farabegoli, Marinella Roberti, Giorgio Oliviero, Andrea Cavalli
Enriching Proteolysis Targeting Chimeras with a Second Modality: When Two Are Better Than One
2022 Salerno, Alessandra; Seghetti, Francesca; Caciolla, Jessica; Uliassi, Elisa; Testi, Eleonora; Guardigni, Melissa; Roberti, Marinella; Milelli, Andrea; Bolognesi, Maria Laura
Identification and subsequent development of RAD51-BRCA2 disruptors through a fragment-based approach
2022 Samuel Harry Myers , Viola Previtali, Laura Poppi, Francesco Rinaldi, Fabrizio Schipani, Jose Antonio Ortega, Francesca De Franco, Marina Veronesi, Roberto Pellicciari, Marinella Roberti, Stefania Girotto, Giuseppina Di Stefano, Andrea Cavalli
Identification of RAD51-BRCA2 Inhibitors Using N-Acylhydrazone-Based Dynamic Combinatorial Chemistry
2022 Bagnolini, G.; Balboni, B.; Schipani, F.; Gioia, D.; Veronesi, M.; De Franco, F.; Kaya, C.; Jumde, R. P.; Ortega, J. A.; Girotto, S.; Hirsch, A. K. H.; Roberti, M.; Cavalli, A.
Insights into the activity of ARN24089, a new RAD51-BRCA2 disruptor that inhibits homologous recombination and achieves synthetic lethality in pancreatic cancer
2022 Previtali V., Myers S. H., Bagnolini G., Poppi L., Rinaldi F., Schipani F., Ortega J. A., De Franco F., Pellicciari R., Girotto S., Oliviero G., Walsh N., Valenti G., Tirelli N., Di Stefano G., Roberti M., Cavalli A.
Proteostasis Regulators in Cystic Fibrosis: Current Development and Future Perspectives
2022 Brusa I.; Sondo E.; Falchi F.; Pedemonte N.; Roberti M.; Cavalli A.
The Mechanistic Understanding of RAD51 Defibrillation: A Critical Step in BRCA2-Mediated DNA Repair by Homologous Recombination
2022 Schipani, Fabrizio; Manerba, Marcella; Marotta, Roberto; Poppi, Laura; Gennari, Arianna; Rinaldi, Francesco; Armirotti, Andrea; Farabegoli, Fulvia; Roberti, Marinella; Di Stefano, Giuseppina; Rocchia, Walter; Girotto, Stefania; Tirelli, Nicola; Cavalli, Andrea
Antiparasitic effect of stilbene and terphenyl compounds against trypanosoma cruzi parasites
2021 Bruno F.; Castelli G.; Vitale F.; Catanzaro S.; Badaco V.V.; Roberti M.; Colomba C.; Cascio A.; Tolomeo M.
Inhibition of Urease, a Ni-Enzyme: The Reactivity of a Key Thiol With Mono- and Di-Substituted Catechols Elucidated by Kinetic, Structural, and Theoretical Studies
2021 Mazzei L.; Contaldo U.; Musiani F.; Cianci M.; Bagnolini G.; Roberti M.; Ciurli S.
Lactate dehydrogenase inhibition affects homologous recombination repair independently of cell metabolic asset; implications for anticancer treatment
2021 Balboni A.; Govoni M.; Rossi V.; Roberti M.; Cavalli A.; Di Stefano G.; Manerba M.
RAD51 nuclear recruitment and inhibition towards innovative strategies against pancreatic cancer
2021 Schipani, Fabrizio; Manerba, Marcella; Marotta, Roberto; Gennari, Arianna; Rinaldi, Francesco; Armirotti, Andrea; Roberti, Marinella; Di Stefano, Giuseppina; Rocchia, Walter; Tirelli, Nicola; Girotto, Stefania; Cavalli, Andrea
Free-radical-mediated formation of trans-cardiolipin isomers, analytical approaches for lipidomics and consequences of the structural organization of membranes
2020 Vetica F.; Sansone A.; Meliota C.; Batani G.; Roberti M.; Chatgilialoglu C.; Ferreri C.
Identification of a 2,4-diaminopyrimidine scaffold targeting Trypanosoma brucei pteridine reductase 1 from the LIBRA compound library screening campaign
2020 Linciano P.; Cullia G.; Borsari C.; Santucci M.; Ferrari S.; Witt G.; Gul S.; Kuzikov M.; Ellinger B.; Santarem N.; Cordeiro da Silva A.; Conti P.; Bolognesi M.L.; Roberti M.; Prati F.; Bartoccini F.; Retini M.; Piersanti G.; Cavalli A.; Goldoni L.; Bertozzi S.M.; Bertozzi F.; Brambilla E.; Rizzo V.; Piomelli D.; Pinto A.; Bandiera T.; Costi M.P.
| Titolo | Autore(i) | Anno | Periodico | Editore | Tipo | File |
|---|---|---|---|---|---|---|
| A journey through targeting BRCA2-RAD51 protein-protein interaction to establish synthetic lethality as paradigm for anticancer drug discovery | Bagnolini G., Poppi L., Previtali V., Ferrandi G., Rinaldi F., Girotto S., Hirsch A.K.H., Roberti... M., Cavalli A. | 2024-01-01 | - | - | 4.01 Contributo in Atti di convegno | - |
| New Horizons of Synthetic Lethality in Cancer: Current Development and Future Perspectives | Previtali, Viola; Bagnolini, Greta; Ciamarone, Andrea; Ferrandi, Giovanni; Rinaldi, Francesco; My...ers, Samuel Harry; Roberti, Marinella; Cavalli, Andrea | 2024-01-01 | JOURNAL OF MEDICINAL CHEMISTRY | - | 1.01 Articolo in rivista | - |
| A RAD51/BRCA2 small molecule inhibitor enhances the antineoplastic effect of the PARPi talazoparib in pancreatic cancer | Laura Poppi, Samuel H Myers, Viola Previtali, Francesco Rinaldi, Fulvia Farabegoli, Giuseppina Di... Stefano, Naomi Walsh, Marinella Roberti, Andrea Cavalli | 2023-01-01 | - | FEBS PRESS | 4.03 Poster | - |
| An 19F NMR fragment-based approach for the discovery and development of BRCA2-RAD51 inhibitors to pursuit synthetic lethality in combination with PARP inhibition in pancreatic cancer | Myers S. H., Poppi L., Rinaldi F., Veronesi M., Ciamarone A., Previtali V., Bagnolini G., Schipan...i F., Ortega Martínez J. A., Girotto S., Di Stefano G., Farabegoli F., Walsh N., De Franco F., Roberti M., Cavalli A. | 2023-01-01 | EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | - | 1.01 Articolo in rivista | 1-s2.0-S0223523423010814-mmc1.docx |
| Application of an “inhalation by design” approach to the identification and in-vitro evaluation of novel purine based PI3Kδ inhibitors | Mazzucato R.; Roberti M.; Capelli A.M.; Rancati F.; Biagetti M.; Fiorelli C.; Bruno P.; Ronchi P....; Bertolini S.; Corsi M.; Pala D. | 2023-01-01 | EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | - | 1.01 Articolo in rivista | - |
| Innovative Strategy toward Mutant CFTR Rescue in Cystic Fibrosis: Design and Synthesis of Thiadiazole Inhibitors of the E3 Ligase RNF5 | Brusa, Irene; Sondo, Elvira; Pesce, Emanuela; Tomati, Valeria; Gioia, Dario; Falchi, Federico; Ba...lboni, Beatrice; Ortega Martínez, Jose Antonio; Veronesi, Marina; Romeo, Elisa; Margaroli, Natasha; Recanatini, Maurizio; Girotto, Stefania; Pedemonte, Nicoletta; Roberti, Marinella; Cavalli, Andrea | 2023-01-01 | JOURNAL OF MEDICINAL CHEMISTRY | - | 1.01 Articolo in rivista | brusa-et-al-2023-innovative-strategy-toward-mutant-cftr-rescue-in-cystic-fibrosis-design-and-synthesis-of-thiadiazole.pdf |
| Preomic profile of BxPC-3 cells after treatment with BRC4 | Previtali V.; Myers S.H.; Poppi L.; Wynne K.; Casamassima I.; Girotto S.; Di Stefano G.; Farabego...li F.; Roberti M.; Oliviero G.; Cavalli A. | 2023-01-01 | JOURNAL OF PROTEOMICS | - | 1.01 Articolo in rivista | - |
| Proteomic profile of BxPC-3 cells after treatment with BRC4 | Viola Previtali, Samuel H. Myers, Laura Poppi, Kieran Wynne, Irene Casamassima Stefania Girotto, ...Giuseppina Di Stefano, Fulvia Farabegoli, Marinella Roberti, Giorgio Oliviero, Andrea Cavalli | 2023-01-01 | JOURNAL OF PROTEOMICS | - | 1.01 Articolo in rivista | - |
| Enriching Proteolysis Targeting Chimeras with a Second Modality: When Two Are Better Than One | Salerno, Alessandra; Seghetti, Francesca; Caciolla, Jessica; Uliassi, Elisa; Testi, Eleonora; Gua...rdigni, Melissa; Roberti, Marinella; Milelli, Andrea; Bolognesi, Maria Laura | 2022-01-01 | JOURNAL OF MEDICINAL CHEMISTRY | - | 1.01 Articolo in rivista | acs.jmedchem.2c00302.pdf |
| Identification and subsequent development of RAD51-BRCA2 disruptors through a fragment-based approach | Samuel Harry Myers , Viola Previtali, Laura Poppi, Francesco Rinaldi, Fabrizio Schipani, Jose Ant...onio Ortega, Francesca De Franco, Marina Veronesi, Roberto Pellicciari, Marinella Roberti, Stefania Girotto, Giuseppina Di Stefano, Andrea Cavalli | 2022-01-01 | - | - | 4.02 Riassunto (Abstract) | - |
| Identification of RAD51-BRCA2 Inhibitors Using N-Acylhydrazone-Based Dynamic Combinatorial Chemistry | Bagnolini, G.; Balboni, B.; Schipani, F.; Gioia, D.; Veronesi, M.; De Franco, F.; Kaya, C.; Jumde..., R. P.; Ortega, J. A.; Girotto, S.; Hirsch, A. K. H.; Roberti, M.; Cavalli, A. | 2022-01-01 | ACS MEDICINAL CHEMISTRY LETTERS | - | 1.01 Articolo in rivista | acsmedchemlett._2022.pdf |
| Insights into the activity of ARN24089, a new RAD51-BRCA2 disruptor that inhibits homologous recombination and achieves synthetic lethality in pancreatic cancer | Previtali V., Myers S. H., Bagnolini G., Poppi L., Rinaldi F., Schipani F., Ortega J. A., De Fran...co F., Pellicciari R., Girotto S., Oliviero G., Walsh N., Valenti G., Tirelli N., Di Stefano G., Roberti M., Cavalli A. | 2022-01-01 | - | - | 4.02 Riassunto (Abstract) | - |
| Proteostasis Regulators in Cystic Fibrosis: Current Development and Future Perspectives | Brusa I.; Sondo E.; Falchi F.; Pedemonte N.; Roberti M.; Cavalli A. | 2022-01-01 | JOURNAL OF MEDICINAL CHEMISTRY | - | 1.01 Articolo in rivista | acs.jmedchem.1c01897.pdf |
| The Mechanistic Understanding of RAD51 Defibrillation: A Critical Step in BRCA2-Mediated DNA Repair by Homologous Recombination | Schipani, Fabrizio; Manerba, Marcella; Marotta, Roberto; Poppi, Laura; Gennari, Arianna; Rinaldi,... Francesco; Armirotti, Andrea; Farabegoli, Fulvia; Roberti, Marinella; Di Stefano, Giuseppina; Rocchia, Walter; Girotto, Stefania; Tirelli, Nicola; Cavalli, Andrea | 2022-01-01 | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | - | 1.01 Articolo in rivista | ijms-23-08338-v3 (1).pdf |
| Antiparasitic effect of stilbene and terphenyl compounds against trypanosoma cruzi parasites | Bruno F.; Castelli G.; Vitale F.; Catanzaro S.; Badaco V.V.; Roberti M.; Colomba C.; Cascio A.; T...olomeo M. | 2021-01-01 | PHARMACEUTICALS | - | 1.01 Articolo in rivista | pharmaceuticals 2020.pdf |
| Inhibition of Urease, a Ni-Enzyme: The Reactivity of a Key Thiol With Mono- and Di-Substituted Catechols Elucidated by Kinetic, Structural, and Theoretical Studies | Mazzei L.; Contaldo U.; Musiani F.; Cianci M.; Bagnolini G.; Roberti M.; Ciurli S. | 2021-01-01 | ANGEWANDTE CHEMIE. INTERNATIONAL EDITION | - | 1.01 Articolo in rivista | Manuscript.pdf; Supplementary Information.pdf |
| Lactate dehydrogenase inhibition affects homologous recombination repair independently of cell metabolic asset; implications for anticancer treatment | Balboni A.; Govoni M.; Rossi V.; Roberti M.; Cavalli A.; Di Stefano G.; Manerba M. | 2021-01-01 | BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS | - | 1.01 Articolo in rivista | - |
| RAD51 nuclear recruitment and inhibition towards innovative strategies against pancreatic cancer | Schipani, Fabrizio; Manerba, Marcella; Marotta, Roberto; Gennari, Arianna; Rinaldi, Francesco; Ar...mirotti, Andrea; Roberti, Marinella; Di Stefano, Giuseppina; Rocchia, Walter; Tirelli, Nicola; Girotto, Stefania; Cavalli, Andrea | 2021-01-01 | bioRxiv | - | 1.01 Articolo in rivista | - |
| Free-radical-mediated formation of trans-cardiolipin isomers, analytical approaches for lipidomics and consequences of the structural organization of membranes | Vetica F.; Sansone A.; Meliota C.; Batani G.; Roberti M.; Chatgilialoglu C.; Ferreri C. | 2020-01-01 | BIOMOLECULES | - | 1.01 Articolo in rivista | biomolecules-10-01189 (1).pdf |
| Identification of a 2,4-diaminopyrimidine scaffold targeting Trypanosoma brucei pteridine reductase 1 from the LIBRA compound library screening campaign | Linciano P.; Cullia G.; Borsari C.; Santucci M.; Ferrari S.; Witt G.; Gul S.; Kuzikov M.; Ellinge...r B.; Santarem N.; Cordeiro da Silva A.; Conti P.; Bolognesi M.L.; Roberti M.; Prati F.; Bartoccini F.; Retini M.; Piersanti G.; Cavalli A.; Goldoni L.; Bertozzi S.M.; Bertozzi F.; Brambilla E.; Rizzo V.; Piomelli D.; Pinto A.; Bandiera T.; Costi M.P. | 2020-01-01 | EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | - | 1.01 Articolo in rivista | - |