Our findings support a model in which the GSK3 pathway can exerts a negative control on p75NTR transcription in high risk neuroblastoma and highlight the possibility to use GSK3 inhibitors as potential therapeutic drugs to treat neuroblastoma with low p75NTR.
Giovanni Perini, Emanuele Valli, Samuele Gherardi, Simone Di Giacomo, Giorgio Milazzo, Timothy R. Wagenaar, et al. (2012). A genome-scale shRNA screen identifies GSK3 as a critical regulator of p75NTR transcription in high risk neuroblastoma.
A genome-scale shRNA screen identifies GSK3 as a critical regulator of p75NTR transcription in high risk neuroblastoma
PERINI, GIOVANNI;VALLI, EMANUELE;GHERARDI, SAMUELE;DI GIACOMO, SIMONE;MILAZZO, GIORGIO;
2012
Abstract
Our findings support a model in which the GSK3 pathway can exerts a negative control on p75NTR transcription in high risk neuroblastoma and highlight the possibility to use GSK3 inhibitors as potential therapeutic drugs to treat neuroblastoma with low p75NTR.File in questo prodotto:
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