MILAZZO, GIORGIO
MILAZZO, GIORGIO
DIPARTIMENTO DI FARMACIA E BIOTECNOLOGIE
Ricercatori a tempo determinato
The transcriptional co-repressor Runx1t1 is essential for MYCN-driven neuroblastoma tumorigenesis
2024 Murray, J. E.; Valli, E.; Milazzo, G.; Mayoh, C.; Gifford, A. J.; Fletcher, J. I.; Xue, C.; Jayatilleke, N.; Salehzadeh, F.; Gamble, L. D.; Rouaen, J. R. C.; Carter, D. R.; Forgham, H.; Sekyere, E. O.; Keating, J.; Eden, G.; Allan, S.; Alfred, S.; Kusuma, F. K.; Clark, A.; Webber, H.; Russell, A. J.; de Weck, A.; Kile, B. T.; Santulli, M.; De Rosa, P.; Fleuren, E. D. G.; Gao, W.; Wilkinson-White, L.; Low, J. K. K.; Mackay, J. P.; Marshall, G. M.; Hilton, D. J.; Giorgi, F. M.; Koster, J.; Perini, G.; Haber, M.; Norris, M. D.
MYCN Amplification, along with Wild-Type RB1 Expression, Enhances CDK4/6 Inhibitors’ Efficacy in Neuroblastoma Cells
2023 De Rosa P.; Severi F.; Zadran S.K.; Russo M.; Aloisi S.; Rigamonti A.; Capranico G.; Milazzo G.; Perini G.
Contribution of CACNA1H variants in Autism Spectrum Disorder Susceptibility
2022 Marta Viggiano, Tiziano D’Andrea, Cinzia Cameli, Annio Posar, Paola Visconti, Maria Cristina Scaduto, Roberta Colucci, Fabiola Ceroni, Giorgio Milazzo, Sergio Fucile, Elena Maestrini, Elena Bacchelli
Contribution of CACNA1H Variants in Autism Spectrum Disorder Susceptibility
2022 Viggiano, Marta; D'Andrea, Tiziano; Cameli, Cinzia; Posar, Annio; Visconti, Paola; Scaduto, Maria Cristina; Colucci, Roberta; Rochat, Magali J.; Ceroni, Fabiola; Milazzo, Giorgio; Fucile, Sergio; Maestrini, Elena; Bacchelli, Elena
Contribution of compound heterozygous CACNA1H mutations in autism spectrum disorder susceptibility
2022 Marta Viggiano, Tiziano D'Andrea, Cinzia Cameli, Annio Posar, Maria C. Scaduto, Roberta Colucci, Magalì Rochat, Fabiola Ceroni, Giorgio Milazzo, Sergio Fucile, Paola Visconti, Elena Bacchelli, Elena Maestrini
MYCN-driven fatty acid uptake is a metabolic vulnerability in neuroblastoma
2022 Tao L.; Mohammad M.A.; Milazzo G.; Moreno-Smith M.; Patel T.D.; Zorman B.; Badachhape A.; Hernandez B.E.; Wolf A.B.; Zeng Z.; Foster J.H.; Aloisi S.; Sumazin P.; Zu Y.; Hicks J.; Ghaghada K.B.; Putluri N.; Perini G.; Coarfa C.; Barbieri E.
Single-Cell Sequencing Identifies Master Regulators Affected by Panobinostat in Neuroblastoma Cells
2022 Milazzo G.; Perini G.; Giorgi F.M.
A g316a polymorphism in the ornithine decarboxylase gene promoter modulates mycn‐driven childhood neuroblastoma
2021 Gamble L.D.; Purgato S.; Henderson M.J.; Di Giacomo S.; Russell A.J.; Pigini P.; Murray J.; Valli E.; Milazzo G.; Giorgi F.M.; Cowley M.; Ashton L.J.; Bhalshankar J.; Schleiermacher G.; Rihani A.; Van Maerken T.; Vandesompele J.; Speleman F.; Versteeg R.; Koster J.; Eggert A.; Noguera R.; Stallings R.L.; Tonini G.P.; Fong K.; Vaksman Z.; Diskin S.J.; Maris J.M.; London W.B.; Marshall G.M.; Ziegler D.S.; Hogarty M.D.; Perini G.; Norris M.D.; Haber M.
CHAF1A Blocks Neuronal Differentiation and Promotes Neuroblastoma Oncogenesis via Metabolic Reprogramming
2021 Tao L.; Moreno-Smith M.; Ibarra-Garcia-Padilla R.; Milazzo G.; Drolet N.A.; Hernandez B.E.; Oh Y.S.; Patel I.; Kim J.J.; Zorman B.; Patel T.; Kamal A.H.M.; Zhao Y.; Hicks J.; Vasudevan S.A.; Putluri N.; Coarfa C.; Sumazin P.; Perini G.; Parchem R.J.; Uribe R.A.; Barbieri E.
Restoration of the molecular clock is tumor suppressive in neuroblastoma
2021 Moreno-Smith M.; Milazzo G.; Tao L.; Fekry B.; Zhu B.; Mohammad M.A.; Di Giacomo S.; Borkar R.; Reddy K.R.K.; Capasso M.; Vasudevan S.A.; Sumazin P.; Hicks J.; Putluri N.; Perini G.; Eckel-Mahan K.; Burris T.P.; Barbieri E.
Targeting oncogenic transcriptional networks in neuroblastoma: From N-Myc to epigenetic drugs
2021 Ciaccio R.; De Rosa P.; Aloisi S.; Viggiano M.; Cimadom L.; Zadran S.K.; Perini G.; Milazzo G.
Histone deacetylases (HDACs): Evolution, specificity, role in transcriptional complexes, and pharmacological actionability
2020 Milazzo G.; Mercatelli D.; Di Muzio G.; Triboli L.; De Rosa P.; Perini G.; Giorgi F.M.
Drugging MYCN oncogenic signalling through the MYCN-PA2G4 binding interface
2019 Koach, Jessica; Holien, Jessica K; Massudi, Hassina; Carter, Daniel R; Ciampa, Olivia C; Herath, Mika; Lim, Taylor; Seneviratne, Janith A; Milazzo, Giorgio; Murray, Jayne E; McCarroll, Joshua A; Liu, Bing; Mayoh, Chelsea; Keenan, Bryce; Stevenson, Brendan W; Gorman, Michael A; Bell, Jessica L; Doughty, Larissa; Hüttelmaier, Stefan; Oberthuer, Andre; Fischer, Matthias; Gifford, Andrew J; Liu, Tao; Zhang, Xiaoling; Zhu, Shizhen; Gustafson, W Clay; Haber, Michelle; Norris, Murray D; Fletcher, Jamie I; Perini, Giovanni; Parker, Michael W; Cheung, Belamy B; Marshall, Glenn M
Inhibition of polyamine synthesis and uptake reduces tumor progression and prolongs survival in mouse models of neuroblastoma
2019 Laura D. Gamble, Stefania Purgato, Jayne Murray, Lin Xiao, Denise M. T. Yu, Kimberley M. Hanssen, Federico M. Giorgi, Daniel R. Carter, Andrew J. Gifford, Emanuele Valli, Giorgio Milazzo, Alvin Kamili, Chelsea Mayoh, Bing Liu, Georgina Eden, Sara Sarraf, Sophie Allan, Simone Di Giacomo, Claudia L. Flemming, Amanda J. Russell, Belamy B. Cheung, Andre Oberthuer, Wendy B. London, Matthias Fischer, Toby N. Trahair, Jamie I. Fletcher, Glenn M. Marshall, David S. Ziegler, Michael D. Hogarty, Mark R. Burns, Giovanni Perini, Murray D. Norris, and Michelle Haber
JMJD6 is a tumorigenic factor and therapeutic target in neuroblastoma
2019 Wong M.; Sun Y.; Xi Z.; Milazzo G.; Poulos R.C.; Bartenhagen C.; Bell J.L.; Mayoh C.; Ho N.; Tee A.E.; Chen X.; Li Y.; Ciaccio R.; Liu P.Y.; Jiang C.C.; Lan Q.; Jayatilleke N.; Cheung B.B.; Haber M.; Norris M.D.; Zhang X.D.; Marshall G.M.; Wang J.Y.; Huttelmaier S.; Fischer M.; Wong J.W.H.; Xu H.; Perini G.; Dong Q.; George R.E.; Liu T.
The long noncoding RNA lncNB1 promotes tumorigenesis by interacting with ribosomal protein RPL35
2019 Liu, Pei Y; Tee, Andrew E; Milazzo, Giorgio; Hannan, Katherine M; Maag, Jesper; Mondal, Sujanna; Atmadibrata, Bernard; Bartonicek, Nenad; Peng, Hui; Ho, Nicholas; Mayoh, Chelsea; Ciaccio, Roberto; Sun, Yuting; Henderson, Michelle J; Gao, Jixuan; Everaert, Celine; Hulme, Amy J; Wong, Matthew; Lan, Qing; Cheung, Belamy B; Shi, Leming; Wang, Jenny Y; Simon, Thorsten; Fischer, Matthias; Zhang, Xu D; Marshall, Glenn M; Norris, Murray D; Haber, Michelle; Vandesompele, Jo; Li, Jinyan; Mestdagh, Pieter; Hannan, Ross D; Dinger, Marcel E; Perini, Giovanni; Liu, Tao
Unveiling Early Differentiation Induced by Histone Deacetylase Inhibitors in Neuroblastoma Cell Lines: A Single-Cell Transcriptomics Approach
2019 Giorgio MIlazzo, Daniele Mercatelli, Giovanni Perini, Federico M. Giorgi
Aerobic Growth of Rhodococcus aetherivorans BCP1 Using Selected Naphthenic Acids as the Sole Carbon and Energy Sources
2018 Presentato, Alessandro; Cappelletti, Martina; Sansone, Anna; Ferreri, Carla; Piacenza, Elena; Demeter, Marc A.; Crognale, Silvia; Petruccioli, Maurizio; Milazzo, Giorgio; Fedi, Stefano; Steinbüchel, Alexander; Turner, Raymond J.; Zannoni, Davide
MAX to MYCN intracellular ratio drives the aggressive phenotype and clinical outcome of high risk neuroblastoma
2018 Ferrucci, Francesca; Ciaccio, Roberto; Monticelli, Sara; Pigini, Paolo; di Giacomo, Simone; Purgato, Stefania; Erriquez, Daniela; Bernardoni, Roberto; Norris, Murray; Haber, Michelle; Milazzo, Giorgio; Perini, Giovanni
MYCN acts as a direct co-regulator of p53 in MYCN amplified neuroblastoma
2018 Agarwal, Saurabh; Milazzo, Giorgio; Rajapakshe, Kimal; Bernardi, Ronald; Chen, Zaowen; Barberi, Eveline; Koster, Jan; Perini, Giovanni; Coarfa, Cristian; Shohet, Jason M.*
Titolo | Autore(i) | Anno | Periodico | Editore | Tipo | File |
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The transcriptional co-repressor Runx1t1 is essential for MYCN-driven neuroblastoma tumorigenesis | Murray, J. E.; Valli, E.; Milazzo, G.; Mayoh, C.; Gifford, A. J.; Fletcher, J. I.; Xue, C.; Jayat...illeke, N.; Salehzadeh, F.; Gamble, L. D.; Rouaen, J. R. C.; Carter, D. R.; Forgham, H.; Sekyere, E. O.; Keating, J.; Eden, G.; Allan, S.; Alfred, S.; Kusuma, F. K.; Clark, A.; Webber, H.; Russell, A. J.; de Weck, A.; Kile, B. T.; Santulli, M.; De Rosa, P.; Fleuren, E. D. G.; Gao, W.; Wilkinson-White, L.; Low, J. K. K.; Mackay, J. P.; Marshall, G. M.; Hilton, D. J.; Giorgi, F. M.; Koster, J.; Perini, G.; Haber, M.; Norris, M. D. | 2024-01-01 | NATURE COMMUNICATIONS | - | 1.01 Articolo in rivista | s41467-024-49871-0.pdf |
MYCN Amplification, along with Wild-Type RB1 Expression, Enhances CDK4/6 Inhibitors’ Efficacy in Neuroblastoma Cells | De Rosa P.; Severi F.; Zadran S.K.; Russo M.; Aloisi S.; Rigamonti A.; Capranico G.; Milazzo G.; ...Perini G. | 2023-01-01 | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | - | 1.01 Articolo in rivista | ijms-24-05408-v2.pdf |
Contribution of CACNA1H variants in Autism Spectrum Disorder Susceptibility |
Marta Viggiano, Tiziano D’Andrea, Cinzia Cameli, Annio Posar, Paola Visconti, Maria Cristina Scad...uto, Roberta Colucci, Fabiola Ceroni, Giorgio Milazzo, Sergio Fucile, Elena Maestrini, Elena Bacchelli |
2022-01-01 | - | - | 4.02 Riassunto (Abstract) | - |
Contribution of CACNA1H Variants in Autism Spectrum Disorder Susceptibility | Viggiano, Marta; D'Andrea, Tiziano; Cameli, Cinzia; Posar, Annio; Visconti, Paola; Scaduto, Maria... Cristina; Colucci, Roberta; Rochat, Magali J.; Ceroni, Fabiola; Milazzo, Giorgio; Fucile, Sergio; Maestrini, Elena; Bacchelli, Elena | 2022-01-01 | FRONTIERS IN PSYCHIATRY | - | 1.01 Articolo in rivista | Viggiano et al.pdf; Data-Sheet_1.pdf |
Contribution of compound heterozygous CACNA1H mutations in autism spectrum disorder susceptibility | Marta Viggiano, Tiziano D'Andrea, Cinzia Cameli, Annio Posar, Maria C. Scaduto, Roberta Colucci, ...Magalì Rochat, Fabiola Ceroni, Giorgio Milazzo, Sergio Fucile, Paola Visconti, Elena Bacchelli, Elena Maestrini | 2022-01-01 | EUROPEAN JOURNAL OF HUMAN GENETICS | - | 1.06 Abstract in rivista | Contribution of CACNA1H Variants in Autism Spectrum Disorder Susceptibility.pdf |
MYCN-driven fatty acid uptake is a metabolic vulnerability in neuroblastoma | Tao L.; Mohammad M.A.; Milazzo G.; Moreno-Smith M.; Patel T.D.; Zorman B.; Badachhape A.; Hernand...ez B.E.; Wolf A.B.; Zeng Z.; Foster J.H.; Aloisi S.; Sumazin P.; Zu Y.; Hicks J.; Ghaghada K.B.; Putluri N.; Perini G.; Coarfa C.; Barbieri E. | 2022-01-01 | NATURE COMMUNICATIONS | - | 1.01 Articolo in rivista | Liu T. et al.pdf |
Single-Cell Sequencing Identifies Master Regulators Affected by Panobinostat in Neuroblastoma Cells | Milazzo G.; Perini G.; Giorgi F.M. | 2022-01-01 | GENES | - | 1.01 Articolo in rivista | genes-13-02240.pdf |
A g316a polymorphism in the ornithine decarboxylase gene promoter modulates mycn‐driven childhood neuroblastoma | Gamble L.D.; Purgato S.; Henderson M.J.; Di Giacomo S.; Russell A.J.; Pigini P.; Murray J.; Valli... E.; Milazzo G.; Giorgi F.M.; Cowley M.; Ashton L.J.; Bhalshankar J.; Schleiermacher G.; Rihani A.; Van Maerken T.; Vandesompele J.; Speleman F.; Versteeg R.; Koster J.; Eggert A.; Noguera R.; Stallings R.L.; Tonini G.P.; Fong K.; Vaksman Z.; Diskin S.J.; Maris J.M.; London W.B.; Marshall G.M.; Ziegler D.S.; Hogarty M.D.; Perini G.; Norris M.D.; Haber M. | 2021-01-01 | CANCERS | - | 1.01 Articolo in rivista | cancers-13-01807-v2.pdf |
CHAF1A Blocks Neuronal Differentiation and Promotes Neuroblastoma Oncogenesis via Metabolic Reprogramming | Tao L.; Moreno-Smith M.; Ibarra-Garcia-Padilla R.; Milazzo G.; Drolet N.A.; Hernandez B.E.; Oh Y....S.; Patel I.; Kim J.J.; Zorman B.; Patel T.; Kamal A.H.M.; Zhao Y.; Hicks J.; Vasudevan S.A.; Putluri N.; Coarfa C.; Sumazin P.; Perini G.; Parchem R.J.; Uribe R.A.; Barbieri E. | 2021-01-01 | ADVANCED SCIENCE | - | 1.01 Articolo in rivista | Tao L et al.pdf |
Restoration of the molecular clock is tumor suppressive in neuroblastoma | Moreno-Smith M.; Milazzo G.; Tao L.; Fekry B.; Zhu B.; Mohammad M.A.; Di Giacomo S.; Borkar R.; R...eddy K.R.K.; Capasso M.; Vasudevan S.A.; Sumazin P.; Hicks J.; Putluri N.; Perini G.; Eckel-Mahan K.; Burris T.P.; Barbieri E. | 2021-01-01 | NATURE COMMUNICATIONS | - | 1.01 Articolo in rivista | Myrthala Moreno-Smith et al.pdf |
Targeting oncogenic transcriptional networks in neuroblastoma: From N-Myc to epigenetic drugs | Ciaccio R.; De Rosa P.; Aloisi S.; Viggiano M.; Cimadom L.; Zadran S.K.; Perini G.; Milazzo G. | 2021-01-01 | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | - | 1.01 Articolo in rivista | Ciaccio et al.pdf |
Histone deacetylases (HDACs): Evolution, specificity, role in transcriptional complexes, and pharmacological actionability | Milazzo G.; Mercatelli D.; Di Muzio G.; Triboli L.; De Rosa P.; Perini G.; Giorgi F.M. | 2020-01-01 | GENES | - | 1.01 Articolo in rivista | genes-11-00556-v2_compressed.pdf |
Drugging MYCN oncogenic signalling through the MYCN-PA2G4 binding interface | Koach, Jessica; Holien, Jessica K; Massudi, Hassina; Carter, Daniel R; Ciampa, Olivia C; Herath, ...Mika; Lim, Taylor; Seneviratne, Janith A; Milazzo, Giorgio; Murray, Jayne E; McCarroll, Joshua A; Liu, Bing; Mayoh, Chelsea; Keenan, Bryce; Stevenson, Brendan W; Gorman, Michael A; Bell, Jessica L; Doughty, Larissa; Hüttelmaier, Stefan; Oberthuer, Andre; Fischer, Matthias; Gifford, Andrew J; Liu, Tao; Zhang, Xiaoling; Zhu, Shizhen; Gustafson, W Clay; Haber, Michelle; Norris, Murray D; Fletcher, Jamie I; Perini, Giovanni; Parker, Michael W; Cheung, Belamy B; Marshall, Glenn M | 2019-01-01 | CANCER RESEARCH | - | 1.01 Articolo in rivista | Drugging MYCN Oncogenic Signaling through the MYCN-PA2G4 Binding Interface.pdf |
Inhibition of polyamine synthesis and uptake reduces tumor progression and prolongs survival in mouse models of neuroblastoma | Laura D. Gamble, Stefania Purgato, Jayne Murray, Lin Xiao, Denise M. T. Yu, Kimberley M. Hanssen,... Federico M. Giorgi, Daniel R. Carter, Andrew J. Gifford, Emanuele Valli, Giorgio Milazzo, Alvin Kamili, Chelsea Mayoh, Bing Liu, Georgina Eden, Sara Sarraf, Sophie Allan, Simone Di Giacomo, Claudia L. Flemming, Amanda J. Russell, Belamy B. Cheung, Andre Oberthuer, Wendy B. London, Matthias Fischer, Toby N. Trahair, Jamie I. Fletcher, Glenn M. Marshall, David S. Ziegler, Michael D. Hogarty, Mark R. Burns, Giovanni Perini, Murray D. Norris, and Michelle Haber | 2019-01-01 | SCIENCE TRANSLATIONAL MEDICINE | - | 1.01 Articolo in rivista | - |
JMJD6 is a tumorigenic factor and therapeutic target in neuroblastoma | Wong M.; Sun Y.; Xi Z.; Milazzo G.; Poulos R.C.; Bartenhagen C.; Bell J.L.; Mayoh C.; Ho N.; Tee ...A.E.; Chen X.; Li Y.; Ciaccio R.; Liu P.Y.; Jiang C.C.; Lan Q.; Jayatilleke N.; Cheung B.B.; Haber M.; Norris M.D.; Zhang X.D.; Marshall G.M.; Wang J.Y.; Huttelmaier S.; Fischer M.; Wong J.W.H.; Xu H.; Perini G.; Dong Q.; George R.E.; Liu T. | 2019-01-01 | NATURE COMMUNICATIONS | - | 1.01 Articolo in rivista | JMJD6 is a tumorigenic factor and therapeutic target in neuroblastoma.pdf |
The long noncoding RNA lncNB1 promotes tumorigenesis by interacting with ribosomal protein RPL35 | Liu, Pei Y; Tee, Andrew E; Milazzo, Giorgio; Hannan, Katherine M; Maag, Jesper; Mondal, Sujanna; ...Atmadibrata, Bernard; Bartonicek, Nenad; Peng, Hui; Ho, Nicholas; Mayoh, Chelsea; Ciaccio, Roberto; Sun, Yuting; Henderson, Michelle J; Gao, Jixuan; Everaert, Celine; Hulme, Amy J; Wong, Matthew; Lan, Qing; Cheung, Belamy B; Shi, Leming; Wang, Jenny Y; Simon, Thorsten; Fischer, Matthias; Zhang, Xu D; Marshall, Glenn M; Norris, Murray D; Haber, Michelle; Vandesompele, Jo; Li, Jinyan; Mestdagh, Pieter; Hannan, Ross D; Dinger, Marcel E; Perini, Giovanni; Liu, Tao | 2019-01-01 | NATURE COMMUNICATIONS | - | 1.01 Articolo in rivista | The long noncoding RNA lncNB1 promotes tumorigenesis by interacting with ribosomal protein RPL35.pdf |
Unveiling Early Differentiation Induced by Histone Deacetylase Inhibitors in Neuroblastoma Cell Lines: A Single-Cell Transcriptomics Approach | Giorgio MIlazzo, Daniele Mercatelli, Giovanni Perini, Federico M. Giorgi | 2019-01-01 | - | - | 4.02 Riassunto (Abstract) | - |
Aerobic Growth of Rhodococcus aetherivorans BCP1 Using Selected Naphthenic Acids as the Sole Carbon and Energy Sources | Presentato, Alessandro; Cappelletti, Martina; Sansone, Anna; Ferreri, Carla; Piacenza, Elena; Dem...eter, Marc A.; Crognale, Silvia; Petruccioli, Maurizio; Milazzo, Giorgio; Fedi, Stefano; Steinbüchel, Alexander; Turner, Raymond J.; Zannoni, Davide | 2018-01-01 | FRONTIERS IN MICROBIOLOGY | - | 1.01 Articolo in rivista | fmicb-09-00672-1.pdf |
MAX to MYCN intracellular ratio drives the aggressive phenotype and clinical outcome of high risk neuroblastoma | Ferrucci, Francesca; Ciaccio, Roberto; Monticelli, Sara; Pigini, Paolo; di Giacomo, Simone; Purga...to, Stefania; Erriquez, Daniela; Bernardoni, Roberto; Norris, Murray; Haber, Michelle; Milazzo, Giorgio; Perini, Giovanni | 2018-01-01 | BIOCHIMICA ET BIOPHYSICA ACTA | - | 1.01 Articolo in rivista | - |
MYCN acts as a direct co-regulator of p53 in MYCN amplified neuroblastoma | Agarwal, Saurabh; Milazzo, Giorgio; Rajapakshe, Kimal; Bernardi, Ronald; Chen, Zaowen; Barberi, E...veline; Koster, Jan; Perini, Giovanni; Coarfa, Cristian; Shohet, Jason M.* | 2018-01-01 | ONCOTARGET | - | 1.01 Articolo in rivista | - |