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EnglishThe design and synthesis of anticancer E-3-(3,4,5-trimethoxybenzilidene)-1,3-dihydroindol-2-ones is reported. Strong COMPARE correlations among the cell line responses suggest that these compounds may be acting similarly through a combination of different mechanisms of action. The 5-methoxy derivative was the most active compound with a mean pGI50 of 6.34, and it is now under review by Biological Evaluation Committee of the National Cancer Institute for possible further studies.
| Titolo: | Antitumor Activity of Substituted E-3-(3,4,5-Trimethoxybenzylidene)-1,3-dihydroindol-2-ones |
| Autore/i: | ANDREANI, ALDO; BURNELLI, SILVIA; GRANAIOLA, MASSIMILIANO; LEONI, ALBERTO; LOCATELLI, ALESSANDRA; MORIGI, RITA; RAMBALDI, MIRELLA; VAROLI, LUCILLA; M. W. Kunkel |
| Autore/i Unibo: | |
| Anno: | 2006 |
| Rivista: | |
| Digital Object Identifier (DOI): | http://dx.doi.org/10.1021/jm0607808 |
| Abstract: | The design and synthesis of anticancer E-3-(3,4,5-trimethoxybenzilidene)-1,3-dihydroindol-2-ones is reported. Strong COMPARE correlations among the cell line responses suggest that these compounds may be acting similarly through a combination of different mechanisms of action. The 5-methoxy derivative was the most active compound with a mean pGI50 of 6.34, and it is now under review by Biological Evaluation Committee of the National Cancer Institute for possible further studies. |
| Data prodotto definitivo in UGOV: | 2007-01-11 11:28:23 |
| Appare nelle tipologie: | 1.01 Articolo in rivista |
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