The design and synthesis of anticancer E-3-(3,4,5-trimethoxybenzilidene)-1,3-dihydroindol-2-ones is reported. Strong COMPARE correlations among the cell line responses suggest that these compounds may be acting similarly through a combination of different mechanisms of action. The 5-methoxy derivative was the most active compound with a mean pGI50 of 6.34, and it is now under review by Biological Evaluation Committee of the National Cancer Institute for possible further studies.

Antitumor Activity of Substituted E-3-(3,4,5-Trimethoxybenzylidene)-1,3-dihydroindol-2-ones

ANDREANI, ALDO;BURNELLI, SILVIA;GRANAIOLA, MASSIMILIANO;LEONI, ALBERTO;LOCATELLI, ALESSANDRA;MORIGI, RITA;RAMBALDI, MIRELLA;VAROLI, LUCILLA;
2006

Abstract

The design and synthesis of anticancer E-3-(3,4,5-trimethoxybenzilidene)-1,3-dihydroindol-2-ones is reported. Strong COMPARE correlations among the cell line responses suggest that these compounds may be acting similarly through a combination of different mechanisms of action. The 5-methoxy derivative was the most active compound with a mean pGI50 of 6.34, and it is now under review by Biological Evaluation Committee of the National Cancer Institute for possible further studies.
A. Andreani; S. Burnelli; M. Granaiola; A. Leoni; A. Locatelli; R. Morigi; M. Rambaldi; L. Varoli; M.W. Kunkel
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11585/33529
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