Extracts from Stevia rebaudiana Bertoni, a plant native to Central and South America, have been used as a sweetener since ancient times. Currently, Stevia extracts are largely used as a noncaloric high-potency biosweetener alternative to sugar, due to the growing incidence of type 2 diabetes mellitus, obesity, and metabolic disorders worldwide. Despite the large number of studies on Stevia and steviol glycosides in vivo, little is reported concerning the cellular and molecular mechanisms underpinning the beneficial effects on human health.The effect of four commercial Stevia extracts on glucose transport activity was evaluated in HL-60 human leukaemia and in SH-SY5Y human neuroblastoma cells.The extracts were able to enhance glucose uptake in both cellular lines, as efficiently as insulin. Our data suggest that steviol glycosides could act by modulating GLUT translocation through the PI3K/Akt pathway since treatments with both insulin and Stevia extracts increased the phosphorylation of PI3K and Akt. Furthermore, Stevia extracts were able to revert the effect of the reduction of glucose uptake caused by methylglyoxal, an inhibitor of the insulin receptor/PI3K/Akt pathway. These results corroborate the hypothesis that Stevia extracts could mimic insulin effects modulating PI3K/Akt pathway.

Rizzo B, Zambonin L, Angeloni C, Leoncini E, Vieceli Dalla Sega F, Prata C, et al. (2013). Steviol glycosides modulate glucose transport in different cell types. OXIDATIVE MEDICINE AND CELLULAR LONGEVITY, 2013, 1-11 [10.1155/2013/348169].

Steviol glycosides modulate glucose transport in different cell types.

RIZZO, BENEDETTA;ZAMBONIN, LAURA;ANGELONI, CRISTINA;LEONCINI, EMANUELA;VIECELI DALLA SEGA, FRANCESCO;PRATA, CECILIA;FIORENTINI, DIANA;HRELIA, SILVANA
2013

Abstract

Extracts from Stevia rebaudiana Bertoni, a plant native to Central and South America, have been used as a sweetener since ancient times. Currently, Stevia extracts are largely used as a noncaloric high-potency biosweetener alternative to sugar, due to the growing incidence of type 2 diabetes mellitus, obesity, and metabolic disorders worldwide. Despite the large number of studies on Stevia and steviol glycosides in vivo, little is reported concerning the cellular and molecular mechanisms underpinning the beneficial effects on human health.The effect of four commercial Stevia extracts on glucose transport activity was evaluated in HL-60 human leukaemia and in SH-SY5Y human neuroblastoma cells.The extracts were able to enhance glucose uptake in both cellular lines, as efficiently as insulin. Our data suggest that steviol glycosides could act by modulating GLUT translocation through the PI3K/Akt pathway since treatments with both insulin and Stevia extracts increased the phosphorylation of PI3K and Akt. Furthermore, Stevia extracts were able to revert the effect of the reduction of glucose uptake caused by methylglyoxal, an inhibitor of the insulin receptor/PI3K/Akt pathway. These results corroborate the hypothesis that Stevia extracts could mimic insulin effects modulating PI3K/Akt pathway.
2013
Rizzo B, Zambonin L, Angeloni C, Leoncini E, Vieceli Dalla Sega F, Prata C, et al. (2013). Steviol glycosides modulate glucose transport in different cell types. OXIDATIVE MEDICINE AND CELLULAR LONGEVITY, 2013, 1-11 [10.1155/2013/348169].
Rizzo B; Zambonin L; Angeloni C; Leoncini E; Vieceli Dalla Sega F; Prata C; Fiorentini D; Hrelia S.
File in questo prodotto:
Eventuali allegati, non sono esposti

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11585/219274
 Attenzione

Attenzione! I dati visualizzati non sono stati sottoposti a validazione da parte dell'ateneo

Citazioni
  • ???jsp.display-item.citation.pmc??? 8
  • Scopus 52
  • ???jsp.display-item.citation.isi??? 43
social impact