A database of nonredundant structures of EF-hand domains - i.e., pairs of helix-loop-helix motifs - has been assembled, and the six angles among the four helices re-determined. A principal component analysis of these angles allows us to use two such components (PC1 and PC2) to describe the system retaining 80% of the total variance. A PC2 against PC1 plot representation allows us to represent in a compact way the full range of structural diversity of EF-hand domains, their grouping into protein families, and the variation for each family upon calcium and peptide binding.
E. Babini, I. Bertini, F. Capozzi, C. Luchinat, A. Quattrone, M. Turano (2005). Principal Component Analysis of the Conformational Freedom within the EF-Hand Superfamily. JOURNAL OF PROTEOME RESEARCH, 4, 1961-1971 [10.1021/pr050148n].
Principal Component Analysis of the Conformational Freedom within the EF-Hand Superfamily
BABINI, ELENA;CAPOZZI, FRANCESCO;TURANO, MARIA
2005
Abstract
A database of nonredundant structures of EF-hand domains - i.e., pairs of helix-loop-helix motifs - has been assembled, and the six angles among the four helices re-determined. A principal component analysis of these angles allows us to use two such components (PC1 and PC2) to describe the system retaining 80% of the total variance. A PC2 against PC1 plot representation allows us to represent in a compact way the full range of structural diversity of EF-hand domains, their grouping into protein families, and the variation for each family upon calcium and peptide binding.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
