OBJECTIVES: Although the etiology of liver disease affects the features of hepatocellular carcinoma (HCC) diagnosed during surveillance, it is not known whether it influences patients' survival. We analyzed the impact of etiology on the characteristics and outcome of HCC detected during surveillance. METHODS: In this cohort study, 742 patients with HCC detected during semiannual or annual surveillance were selected from the ITA.LI.CA database, including 1,834 consecutive patients observed in three primary and seven tertiary care settings for HCC. Patients were grouped according to etiology: hepatitis B virus (HBV, 87), hepatitis C virus (HCV, 461), alcohol (59), and multietiology (135). RESULTS: In all etiologic groups, most HCCs were unifocal (51-68%) and most of them were
Franco Trevisani, Giulia Magini, Valentina Santi, Antonio Maria Morselli-Labate, Maria Chiara Cantarini, Maria Anna Di Nolfo, et al. (2007). Impact of etiology of cirrhosis on the survival of patients diagnosed with hepatocellular carcinoma during surveillance. THE AMERICAN JOURNAL OF GASTROENTEROLOGY, 102(5), 1022-1031 [10.1111/j.1572-0241.2007.01100.x].
Impact of etiology of cirrhosis on the survival of patients diagnosed with hepatocellular carcinoma during surveillance.
Franco Trevisani;Giulia Magini;Valentina Santi;Antonio Maria Morselli-Labate;Maria Chiara Cantarini;Marco Zoli;Mauro Bernardi;Pietro AndreoneMembro del Collaboration Group
;Maurizio BiselliMembro del Collaboration Group
;Paolo CaraceniMembro del Collaboration Group
;Carmela CursaroMembro del Collaboration Group
;Marco DomenicaliMembro del Collaboration Group
;Annagiulia GramenziMembro del Collaboration Group
;LI BASSI, SILVIAMembro del Collaboration Group
;Donatella MagalottiMembro del Collaboration Group
;Federica Mirici CappaMembro del Collaboration Group
;Andrea ZambruniMembro del Collaboration Group
;Gian Luca GraziMembro del Collaboration Group
;Bruno NardoMembro del Collaboration Group
;Matteo RavaioliMembro del Collaboration Group
;Cristina RossiMembro del Collaboration Group
;Rita GolfieriMembro del Collaboration Group
2007
Abstract
OBJECTIVES: Although the etiology of liver disease affects the features of hepatocellular carcinoma (HCC) diagnosed during surveillance, it is not known whether it influences patients' survival. We analyzed the impact of etiology on the characteristics and outcome of HCC detected during surveillance. METHODS: In this cohort study, 742 patients with HCC detected during semiannual or annual surveillance were selected from the ITA.LI.CA database, including 1,834 consecutive patients observed in three primary and seven tertiary care settings for HCC. Patients were grouped according to etiology: hepatitis B virus (HBV, 87), hepatitis C virus (HCV, 461), alcohol (59), and multietiology (135). RESULTS: In all etiologic groups, most HCCs were unifocal (51-68%) and most of them wereI documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
