The purpose of this work was the formulation of liposomes for nasal administration of tacrine-HCl. This route has many advantages; in particular is possible to convey the drug directly to the Central Nervous System, through the olfactory bulb. Part of Tacrine administered can also be absorbed into the systemic circulation avoiding hepatic first pass effect. Liposomes were formulated with ingredients that have a beneficial effect against the disease. In particular, the classical excipients cholesterol and phosphatidylcholine were enriched with α-tocopherol and polyunsaturated fatty acid EPA and DHA. This formulative approach allowed us to obtain 100% active liposomes against symptoms of Alzheimer's disease.
G. Corace, F. Bigucci, C. Angeloni, E. Motori, S. Hrelia, P.C. Stein, et al. (2012). Multifunctional liposomes encapsulating anti-Alzheimer drug for nasal delivery to central nervous system. s.l : AitUN.
Multifunctional liposomes encapsulating anti-Alzheimer drug for nasal delivery to central nervous system
CORACE, GIUSEPPE;BIGUCCI, FEDERICA;ANGELONI, CRISTINA;HRELIA, SILVANA;GOTTI, ROBERTO;ZECCHI, VITTORIO;LUPPI, BARBARA
2012
Abstract
The purpose of this work was the formulation of liposomes for nasal administration of tacrine-HCl. This route has many advantages; in particular is possible to convey the drug directly to the Central Nervous System, through the olfactory bulb. Part of Tacrine administered can also be absorbed into the systemic circulation avoiding hepatic first pass effect. Liposomes were formulated with ingredients that have a beneficial effect against the disease. In particular, the classical excipients cholesterol and phosphatidylcholine were enriched with α-tocopherol and polyunsaturated fatty acid EPA and DHA. This formulative approach allowed us to obtain 100% active liposomes against symptoms of Alzheimer's disease.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
