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EnglishOxidative stress plays an important role in the pathogenesis of the Alzheimer disease, many epidemiological studies have shown an improvement in cognitive activity and a slowing of disease progression following the administration of antioxidant molecules. Furthermore a previous work has shown that α-tocopherol enriched human lipoproteins enhance the survival of developing rat neurons in vitro [1]. It has recently been shown that when the brain is rich in DHA (an omega-3 fatty acid that can also be biosynthesized starting from α-linolenic acid), production of amyloid plaques is lower, with a decrease of characteristic symptoms of the disease [2]. The purpose of this work was the formulation of liposomes for nasal administration of tacrine-HCl. This route has many advantages; in particular is possible to convey the drug directly to the Central Nervous System (CNS), through the olfactory bulb[3] [4] [5]. Part of Tacrine administered can also be absorbed into the systemic circulation avoiding hepatic first pass effect. Liposomes were formulated with ingredients that have a beneficial effect against the disease. In particular, the classical excipients cholesterol (Cho) and phosphatidylcholine (Phc) were enriched with α-tocopherol (Toc) and polyunsaturated fatty acid EPA and DHA (Ω3). This formulative approach allowed us to obtain 100% active liposomes against symptoms of Alzheimer's disease.
| Titolo: | TACRINE HCl NASAL DELIVERY TO CENTRAL NERVOUS SYSTEM USING ANTIOXIDANT LIPOSOMES | |
| Autore/i: | CORACE, GIUSEPPE; E. Motori; LUPPI, BARBARA; ANGELONI, CRISTINA; BIGUCCI, FEDERICA; S. M. Fischer; M. Brandl; P. Stain; HRELIA, SILVANA; ZECCHI, VITTORIO | |
| Autore/i Unibo: | ||
| Anno: | 2011 | |
| Titolo del libro: | Nanostructured devices for drug delivery: from small molecules to biotech drugs | |
| Pagina iniziale: | 1 | |
| Pagina finale: | 2 | |
| Abstract: | Oxidative stress plays an important role in the pathogenesis of the Alzheimer disease, many epidemiological studies have shown an improvement in cognitive activity and a slowing of disease progression following the administration of antioxidant molecules. Furthermore a previous work has shown that α-tocopherol enriched human lipoproteins enhance the survival of developing rat neurons in vitro [1]. It has recently been shown that when the brain is rich in DHA (an omega-3 fatty acid that can also be biosynthesized starting from α-linolenic acid), production of amyloid plaques is lower, with a decrease of characteristic symptoms of the disease [2]. The purpose of this work was the formulation of liposomes for nasal administration of tacrine-HCl. This route has many advantages; in particular is possible to convey the drug directly to the Central Nervous System (CNS), through the olfactory bulb[3] [4] [5]. Part of Tacrine administered can also be absorbed into the systemic circulation avoiding hepatic first pass effect. Liposomes were formulated with ingredients that have a beneficial effect against the disease. In particular, the classical excipients cholesterol (Cho) and phosphatidylcholine (Phc) were enriched with α-tocopherol (Toc) and polyunsaturated fatty acid EPA and DHA (Ω3). This formulative approach allowed us to obtain 100% active liposomes against symptoms of Alzheimer's disease. | |
| Data prodotto definitivo in UGOV: | 24-giu-2013 | |
| Appare nelle tipologie: | 4.01 Contributo in Atti di convegno |
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