We performed an open label prospective pilot study about cognitive effects of levetiracetam (LEV) in add-on in 10 children affected by epilepsy with generalized or partial seizures. We considered seizure frequency and semeiology, EEG, side effects, behavioural and cognitive features to evaluate efficacy and tolerability of LEV. Cognitive functions resulted unchanged in the sample as a whole, except for an improvement of visuo-spatial abilities and reasoning by analogy. The neuropsychological assessment was unchanged in 9/10 children, one patient had an improvement. LEV seems to be harmless on cognitive functions in childhood epilepsy.
Monti M., Salerno G.G., Montanari M., Posar A., Scaduto M.C., Santucci M., et al. (2011). Gli effetti cognitivi del levetiracetam in età evolutiva..
Gli effetti cognitivi del levetiracetam in età evolutiva.
MONTI, MORENA;SALERNO, GRAZIA GABRIELLA;POSAR, ANNIO;SCADUTO, MARIA CRISTINA;SANTUCCI, MARGHERITA;PARMEGGIANI, ANTONIA
2011
Abstract
We performed an open label prospective pilot study about cognitive effects of levetiracetam (LEV) in add-on in 10 children affected by epilepsy with generalized or partial seizures. We considered seizure frequency and semeiology, EEG, side effects, behavioural and cognitive features to evaluate efficacy and tolerability of LEV. Cognitive functions resulted unchanged in the sample as a whole, except for an improvement of visuo-spatial abilities and reasoning by analogy. The neuropsychological assessment was unchanged in 9/10 children, one patient had an improvement. LEV seems to be harmless on cognitive functions in childhood epilepsy.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
