Peripheral sympathetic neurodegeneration drives cardiac dysfunction in dominant optic atrophy, revealing a critical neuro-cardiac link. Optic atrophy factor-1 haploinsufficiency disrupts mitochondrial dynamics and neurotrophic signaling, causing targeted sympathetic denervation and arrhythmias. Restoring nerve growth factor transport and mitochondrial health in sympathetic neurons represents a promising therapeutic avenue for cardiac autonomic disorders. Future research must unravel mechanisms of neurocardiac crosstalk to develop precise interventions against neurogenic cardiac disease progression.
Ronfini, M., Prando, V., Di Mauro, V., Dokshokova, L., Lazzeri, E., Costantini, I., et al. (2026). OPA1 Deficiency Impairs NGF Signaling and Drives Sympathetic Neurodegeneration. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 11(2), 1-19.
OPA1 Deficiency Impairs NGF Signaling and Drives Sympathetic Neurodegeneration
Di Mauro V;La Morgia C;Liguori R;Sacconi L;Donadio V;Carelli V;
2026
Abstract
Peripheral sympathetic neurodegeneration drives cardiac dysfunction in dominant optic atrophy, revealing a critical neuro-cardiac link. Optic atrophy factor-1 haploinsufficiency disrupts mitochondrial dynamics and neurotrophic signaling, causing targeted sympathetic denervation and arrhythmias. Restoring nerve growth factor transport and mitochondrial health in sympathetic neurons represents a promising therapeutic avenue for cardiac autonomic disorders. Future research must unravel mechanisms of neurocardiac crosstalk to develop precise interventions against neurogenic cardiac disease progression.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
