MUSIANI, FRANCESCO
MUSIANI, FRANCESCO
DIPARTIMENTO DI FARMACIA E BIOTECNOLOGIE
Docenti di ruolo di IIa fascia
A community effort in SARS-CoV-2 drug discovery
2024 Schimunek J.; Seidl P.; Elez K.; Hempel T.; Le T.; Noé F.; Olsson S.; Raich L.; Winter R.; Gokcan H.; Gusev F.; Gutkin E.M.; Isayev O.; Kurnikova M.G.; Narangoda C.H.; Zubatyuk R.; Bosko I.P.; Furs K.V.; Karpenko A.D.; Kornoushenko Y.V.; Shuldau M.; Yushkevich A.; Benabderrahmane M.B.; Bousquet-Melou P.; Bureau R.; Charton B.; Cirou B.C.; Gil G.; Allen W.J.; Sirimulla S.; Watowich S.; Antonopoulos N.; Epitropakis N.; Krasoulis A.; Itsikalis V.; Theodorakis S.; Kozlovskii I.; Maliutin A.; Medvedev A.; Popov P.; Zaretckii M.; Eghbal-Zadeh H.; Halmich C.; Hochreiter S.; Mayr A.; Ruch P.; Widrich M.; Berenger F.; Kumar A.; Yamanishi Y.; Zhang K.Y.J.; Bengio E.; Bengio Y.; Jain M.J.; Korablyov M.; Liu C.H.; Marcou G.; Glaab E.; Barnsley K.; Iyengar S.M.; Ondrechen M.J.; Haupt V.J.; Kaiser F.; Schroeder M.; Pugliese L.; Albani S.; Athanasiou C.; Beccari A.; Carloni P.; D'Arrigo G.; Gianquinto E.; Goßen J.; Hanke A.; Joseph B.P.; Kokh D.B.; Kovachka S.; Manelfi C.; Mukherjee G.; Muñiz-Chicharro A.; Musiani F.; Nunes-Alves A.; Paiardi G.; Rossetti G.; Sadiq S.K.; Spyrakis F.; Talarico C.; Tsengenes A.; Wade R.C.; Copeland C.; Gaiser J.; Olson D.R.; Roy A.; Venkatraman V.; Wheeler T.J.; Arthanari H.; Blaschitz K.; Cespugli M.; Durmaz V.; Fackeldey K.; Fischer P.D.
A computational study to assess the pathogenicity of single or combinations of missense variants on respiratory complex I
2024 Rigobello L.; Lugli F.; Caporali L.; Bartocci A.; Fadanni J.; Zerbetto F.; Iommarini L.; Carelli V.; Ghelli A.M.; Musiani F.
Genetic variants affecting NQO1 protein levels impact the efficacy of idebenone treatment in Leber hereditary optic neuropathy
2024 Aleo S.J.; Del Dotto V.; Romagnoli M.; Fiorini C.; Capirossi G.; Peron C.; Maresca A.; Caporali L.; Capristo M.; Tropeano C.V.; Zanna C.; Ross-Cisneros F.N.; Sadun A.A.; Pignataro M.G.; Giordano C.; Fasano C.; Cavaliere A.; Porcelli A.M.; Tioli G.; Musiani F.; Catania A.; Lamperti C.; Marzoli S.B.; De Negri A.; Cascavilla M.L.; Battista M.; Barboni P.; Carbonelli M.; Amore G.; La Morgia C.; Smirnov D.; Vasilescu C.; Farzeen A.; Blickhaeuser B.; Prokisch H.; Priglinger C.; Livonius B.; Catarino C.B.; Klopstock T.; Tiranti V.; Carelli V.; Ghelli A.M.
Structural and biochemical characterization of Arabidopsis alcohol dehydrogenases reveals distinct functional properties but similar redox sensitivity
2024 Meloni M.; Rossi J.; Fanti S.; Carloni G.; Tedesco D.; Treffon P.; Piccinini L.; Falini G.; Trost P.; Vierling E.; Licausi F.; Giuntoli B.; Musiani F.; Fermani S.; Zaffagnini M.
Variants in Human ATP Synthase Mitochondrial Genes: Biochemical Dysfunctions, Associated Diseases, and Therapies
2024 Del Dotto, Valentina; Musiani, Francesco; Baracca, Alessandra; Solaini, Giancarlo
Conformational response to ligand binding of TMPRSS2, a protease involved in SARS-CoV-2 infection: Insights through computational modeling
2023 Frumenzio G.; Chandramouli B.; Besker N.; Grottesi A.; Talarico C.; Frigerio F.; Emerson A.; Musiani F.
Design, Pharmacological Characterization, and Molecular Docking of Minimalist Peptidomimetic Antagonists of α4β1 Integrin
2023 Baiula, Monica; Anselmi, Michele; Musiani, Francesco; Ghidini, Alessia; Carbone, Jacopo; Caligiana, Alberto; Maurizio, Andrea; Spampinato, Santi; Gentilucci, Luca
Determination and Kinetic Characterization of a New Potential Inhibitor for AmsI Protein Tyrosine Phosphatase from the Apple Pathogen Erwinia amylovora
2023 Albani S.; Polsinelli I.; Mazzei L.; Musiani F.; Benini S.
Functional contacts for activation of urease from Helicobacter pylori: an integrated approach using evolutionary couplings, in-cell enzymatic assays, and computational docking
2023 Carosella, Noemi; Brock, Kelly P.; Zambelli, Barbara; Musiani, Francesco; Sander, Chris; Ciurli, Stefano
Modelling eNvironment for Isoforms (MoNvIso): A general platform to predict structural determinants of protein isoforms in genetic diseases
2023 Oliva, Francesco; Musiani, Francesco; Giorgetti, Alejandro; De Rubeis, Silvia; Sorokina, Oksana; Armstrong, Douglas J; Carloni, Paolo; Ruggerone, Paolo
The structure of the high-affinity nickel-binding site in the Ni,Zn-HypA•UreE2 complex
2023 Zambelli, Barbara; Basak, Priyanka; Hu, Heidi; Piccioli, Mario; Musiani, Francesco; Broll, Valquiria; Imbert, Lionel; Boisbouvier, Jerome; Maroney, Michael J; Ciurli, Stefano
Cloning the barley nec3 disease lesion mimic mutant using complementation by sequencing
2022 Rosignoli, Serena; Cosenza, Francesco; Moscou, Matthew J; Civolani, Laura; Musiani, Francesco; Forestan, Cristian; Milner, Sara Giulia; Savojardo, Castrense; Tuberosa, Roberto; Salvi, Silvio
Computational Study of Helicase from SARS-CoV-2 in RNA-Free and Engaged Form
2022 Di Matteo, Francesca; Frumenzio, Giorgia; Chandramouli, Balasubramanian; Grottesi, Alessandro; Emerson, Andrew; Musiani, Francesco
NDUFS3 knockout cancer cells and molecular docking reveal specificity and mode of action of anti-cancer respiratory complex I inhibitors
2022 Kurelac, Ivana; Cavina, Beatrice; Sollazzo, Manuela; Miglietta, Stefano; Fornasa, Agnese; De Luise, Monica; Iorio, Maria; Lama, Eleonora; Traversa, Daniele; Nasiri, Hamid Razi; Ghelli, Anna; Musiani, Francesco; Porcelli, Anna Maria; Iommarini, Luisa; Gasparre, Giuseppe
New Insights on Rotenone Resistance of Complex I Induced by the m.11778G>A/MT-ND4 Mutation Associated with Leber’s Hereditary Optic Neuropathy
2022 Musiani F.; Rigobello L.; Iommarini L.; Carelli V.; Esposti M.D.; Ghelli A.M.
PacDOCK: A Web Server for Positional Distance-Based and Interaction-Based Analysis of Docking Results
2022 Carbone, Jacopo; Ghidini, Alessia; Romano, Antonio; Gentilucci, Luca; Musiani, Francesco
Relevance of ARID1A Mutations in Endometrial Carcinomas
2022 De Leo A.; Ravegnini G.; Musiani F.; Maloberti T.; Visani M.; Sanza V.; Angelini S.; Perrone A.M.; De Iaco P.; Corradini A.G.; Rosini F.; Grillini M.; Santini D.; Ceccarelli C.; Zamagni C.; Tallini G.; de Biase D.
Respiratory complex I null cancer cells and molecular docking reveal specificity and mode of action inhibitors with anticancer activity
2022 Iommarini, Luisa; Kurelac, Ivana; Cavina, Beatrice; Fornasa, Agnese; Traversa, Daniele; Iorio, Maria; Sollazzo, Manuela; De Luise, Monica; Lama, Eleonora; Nasiri, Hamid Razi; Ghelli, Anna; Musiani, Francesco; Gasparre, Giuseppe; Porcelli, Anna Maria
A blueprint for high affinity SARS-CoV-2 Mpro inhibitors from activity-based compound library screening guided by analysis of protein dynamics
2021 Gossen J.; Albani S.; Hanke A.; Joseph B.P.; Bergh C.; Kuzikov M.; Costanzi E.; Manelfi C.; Storici P.; Gribbon P.; Beccari A.R.; Talarico C.; Spyrakis F.; Lindahl E.; Zaliani A.; Carloni P.; Wade R.C.; Musiani F.; Kokh D.B.; Rossetti G.
Combining Different Docking Engines and Consensus Strategies to Design and Validate Optimized Virtual Screening Protocols for the SARS-CoV-2 3CL Protease
2021 Manelfi C.; Gossen J.; Gervasoni S.; Talarico C.; Albani S.; Philipp B.J.; Musiani F.; Vistoli G.; Rossetti G.; Beccari A.R.; Pedretti A.
| Titolo | Autore(i) | Anno | Periodico | Editore | Tipo | File |
|---|---|---|---|---|---|---|
| A community effort in SARS-CoV-2 drug discovery | Schimunek J.; Seidl P.; Elez K.; Hempel T.; Le T.; Noé F.; Olsson S.; Raich L.; Winter R.; Gokcan... H.; Gusev F.; Gutkin E.M.; Isayev O.; Kurnikova M.G.; Narangoda C.H.; Zubatyuk R.; Bosko I.P.; Furs K.V.; Karpenko A.D.; Kornoushenko Y.V.; Shuldau M.; Yushkevich A.; Benabderrahmane M.B.; Bousquet-Melou P.; Bureau R.; Charton B.; Cirou B.C.; Gil G.; Allen W.J.; Sirimulla S.; Watowich S.; Antonopoulos N.; Epitropakis N.; Krasoulis A.; Itsikalis V.; Theodorakis S.; Kozlovskii I.; Maliutin A.; Medvedev A.; Popov P.; Zaretckii M.; Eghbal-Zadeh H.; Halmich C.; Hochreiter S.; Mayr A.; Ruch P.; Widrich M.; Berenger F.; Kumar A.; Yamanishi Y.; Zhang K.Y.J.; Bengio E.; Bengio Y.; Jain M.J.; Korablyov M.; Liu C.H.; Marcou G.; Glaab E.; Barnsley K.; Iyengar S.M.; Ondrechen M.J.; Haupt V.J.; Kaiser F.; Schroeder M.; Pugliese L.; Albani S.; Athanasiou C.; Beccari A.; Carloni P.; D'Arrigo G.; Gianquinto E.; Goßen J.; Hanke A.; Joseph B.P.; Kokh D.B.; Kovachka S.; Manelfi C.; Mukherjee G.; Muñiz-Chicharro A.; Musiani F.; Nunes-Alves A.; Paiardi G.; Rossetti G.; Sadiq S.K.; Spyrakis F.; Talarico C.; Tsengenes A.; Wade R.C.; Copeland C.; Gaiser J.; Olson D.R.; Roy A.; Venkatraman V.; Wheeler T.J.; Arthanari H.; Blaschitz K.; Cespugli M.; Durmaz V.; Fackeldey K.; Fischer P.D. | 2024-01-01 | MOLECULAR INFORMATICS | - | 1.01 Articolo in rivista | 87_2023_Schimunek_MolInform.pdf |
| A computational study to assess the pathogenicity of single or combinations of missense variants on respiratory complex I | Rigobello L.; Lugli F.; Caporali L.; Bartocci A.; Fadanni J.; Zerbetto F.; Iommarini L.; Carelli ...V.; Ghelli A.M.; Musiani F. | 2024-01-01 | INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES | - | 1.01 Articolo in rivista | 92_2024_Rigobello_IntJBiolMacromol_compressed (1).pdf; 1-s2.0-S0141813024038911-mmc1.pdf |
| Genetic variants affecting NQO1 protein levels impact the efficacy of idebenone treatment in Leber hereditary optic neuropathy | Aleo S.J.; Del Dotto V.; Romagnoli M.; Fiorini C.; Capirossi G.; Peron C.; Maresca A.; Caporali L....; Capristo M.; Tropeano C.V.; Zanna C.; Ross-Cisneros F.N.; Sadun A.A.; Pignataro M.G.; Giordano C.; Fasano C.; Cavaliere A.; Porcelli A.M.; Tioli G.; Musiani F.; Catania A.; Lamperti C.; Marzoli S.B.; De Negri A.; Cascavilla M.L.; Battista M.; Barboni P.; Carbonelli M.; Amore G.; La Morgia C.; Smirnov D.; Vasilescu C.; Farzeen A.; Blickhaeuser B.; Prokisch H.; Priglinger C.; Livonius B.; Catarino C.B.; Klopstock T.; Tiranti V.; Carelli V.; Ghelli A.M. | 2024-01-01 | CELL REPORTS MEDICINE | - | 1.01 Articolo in rivista | 2024 - Aleo - Idebenone and NQO1 - Cell reports Medicine.pdf |
| Structural and biochemical characterization of Arabidopsis alcohol dehydrogenases reveals distinct functional properties but similar redox sensitivity | Meloni M.; Rossi J.; Fanti S.; Carloni G.; Tedesco D.; Treffon P.; Piccinini L.; Falini G.; Trost... P.; Vierling E.; Licausi F.; Giuntoli B.; Musiani F.; Fermani S.; Zaffagnini M. | 2024-01-01 | PLANT JOURNAL | - | 1.01 Articolo in rivista | Postprint_ADHs manuscript_re-revised_final_figures.pdf; tpj16651-sup-0001-supinfo.pdf |
| Variants in Human ATP Synthase Mitochondrial Genes: Biochemical Dysfunctions, Associated Diseases, and Therapies | Del Dotto, Valentina; Musiani, Francesco; Baracca, Alessandra; Solaini, Giancarlo | 2024-01-01 | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | - | 1.01 Articolo in rivista | 2024 Del Dotto Review ATp6 ATP8.pdf |
| Conformational response to ligand binding of TMPRSS2, a protease involved in SARS-CoV-2 infection: Insights through computational modeling | Frumenzio G.; Chandramouli B.; Besker N.; Grottesi A.; Talarico C.; Frigerio F.; Emerson A.; Musi...ani F. | 2023-01-01 | PROTEINS | - | 1.01 Articolo in rivista | 85_2023_Frumenzio_Proteins.pdf |
| Design, Pharmacological Characterization, and Molecular Docking of Minimalist Peptidomimetic Antagonists of α4β1 Integrin | Baiula, Monica; Anselmi, Michele; Musiani, Francesco; Ghidini, Alessia; Carbone, Jacopo; Caligian...a, Alberto; Maurizio, Andrea; Spampinato, Santi; Gentilucci, Luca | 2023-01-01 | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | - | 1.01 Articolo in rivista | Design, Pharmacological Characterization, and Molecular Docking of Minimalist Peptidomimetic Antagonists of 41 Integrin_compressed (1).pdf |
| Determination and Kinetic Characterization of a New Potential Inhibitor for AmsI Protein Tyrosine Phosphatase from the Apple Pathogen Erwinia amylovora | Albani S.; Polsinelli I.; Mazzei L.; Musiani F.; Benini S. | 2023-01-01 | MOLECULES | - | 1.01 Articolo in rivista | 88_2023_Albani_Molecules.pdf; molecules-28-07774-s001.zip |
| Functional contacts for activation of urease from Helicobacter pylori: an integrated approach using evolutionary couplings, in-cell enzymatic assays, and computational docking | Carosella, Noemi; Brock, Kelly P.; Zambelli, Barbara; Musiani, Francesco; Sander, Chris; Ciurli, ...Stefano | 2023-01-01 | Frontiers in Chemical Biology | - | 1.01 Articolo in rivista | - |
| Modelling eNvironment for Isoforms (MoNvIso): A general platform to predict structural determinants of protein isoforms in genetic diseases | Oliva, Francesco; Musiani, Francesco; Giorgetti, Alejandro; De Rubeis, Silvia; Sorokina, Oksana; ...Armstrong, Douglas J; Carloni, Paolo; Ruggerone, Paolo | 2023-01-01 | FRONTIERS IN CHEMISTRY | - | 1.01 Articolo in rivista | 82_2023_Oliva_FrontChem.pdf |
| The structure of the high-affinity nickel-binding site in the Ni,Zn-HypA•UreE2 complex | Zambelli, Barbara; Basak, Priyanka; Hu, Heidi; Piccioli, Mario; Musiani, Francesco; Broll, Valqui...ria; Imbert, Lionel; Boisbouvier, Jerome; Maroney, Michael J; Ciurli, Stefano | 2023-01-01 | METALLOMICS | - | 1.01 Articolo in rivista | - |
| Cloning the barley nec3 disease lesion mimic mutant using complementation by sequencing | Rosignoli, Serena; Cosenza, Francesco; Moscou, Matthew J; Civolani, Laura; Musiani, Francesco; Fo...restan, Cristian; Milner, Sara Giulia; Savojardo, Castrense; Tuberosa, Roberto; Salvi, Silvio | 2022-01-01 | THE PLANT GENOME | - | 1.01 Articolo in rivista | 78_2022_Rosignoli_PlantGenome.pdf |
| Computational Study of Helicase from SARS-CoV-2 in RNA-Free and Engaged Form | Di Matteo, Francesca; Frumenzio, Giorgia; Chandramouli, Balasubramanian; Grottesi, Alessandro; Em...erson, Andrew; Musiani, Francesco | 2022-01-01 | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | - | 1.01 Articolo in rivista | 82_2022_DiMatteo_IJMS_compressed.pdf |
| NDUFS3 knockout cancer cells and molecular docking reveal specificity and mode of action of anti-cancer respiratory complex I inhibitors | Kurelac, Ivana; Cavina, Beatrice; Sollazzo, Manuela; Miglietta, Stefano; Fornasa, Agnese; De Luis...e, Monica; Iorio, Maria; Lama, Eleonora; Traversa, Daniele; Nasiri, Hamid Razi; Ghelli, Anna; Musiani, Francesco; Porcelli, Anna Maria; Iommarini, Luisa; Gasparre, Giuseppe | 2022-01-01 | OPEN BIOLOGY | - | 1.01 Articolo in rivista | rsob.220198.pdf |
| New Insights on Rotenone Resistance of Complex I Induced by the m.11778G>A/MT-ND4 Mutation Associated with Leber’s Hereditary Optic Neuropathy | Musiani F.; Rigobello L.; Iommarini L.; Carelli V.; Esposti M.D.; Ghelli A.M. | 2022-01-01 | MOLECULES | - | 1.01 Articolo in rivista | molecules-27-01341.pdf; molecules-27-01341-s001.zip |
| PacDOCK: A Web Server for Positional Distance-Based and Interaction-Based Analysis of Docking Results | Carbone, Jacopo; Ghidini, Alessia; Romano, Antonio; Gentilucci, Luca; Musiani, Francesco | 2022-01-01 | MOLECULES | - | 1.01 Articolo in rivista | 79_2022_Carbone_Molecules.pdf |
| Relevance of ARID1A Mutations in Endometrial Carcinomas | De Leo A.; Ravegnini G.; Musiani F.; Maloberti T.; Visani M.; Sanza V.; Angelini S.; Perrone A.M....; De Iaco P.; Corradini A.G.; Rosini F.; Grillini M.; Santini D.; Ceccarelli C.; Zamagni C.; Tallini G.; de Biase D. | 2022-01-01 | DIAGNOSTICS | - | 1.01 Articolo in rivista | diagnostics-12-00592-v2.pdf; diagnostics-12-00592-s001.zip |
| Respiratory complex I null cancer cells and molecular docking reveal specificity and mode of action inhibitors with anticancer activity | Iommarini, Luisa; Kurelac, Ivana; Cavina, Beatrice; Fornasa, Agnese; Traversa, Daniele; Iorio, Ma...ria; Sollazzo, Manuela; De Luise, Monica; Lama, Eleonora; Nasiri, Hamid Razi; Ghelli, Anna; Musiani, Francesco; Gasparre, Giuseppe; Porcelli, Anna Maria | 2022-01-01 | BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS | - | 4.02 Riassunto (Abstract) | - |
| A blueprint for high affinity SARS-CoV-2 Mpro inhibitors from activity-based compound library screening guided by analysis of protein dynamics | Gossen J.; Albani S.; Hanke A.; Joseph B.P.; Bergh C.; Kuzikov M.; Costanzi E.; Manelfi C.; Stori...ci P.; Gribbon P.; Beccari A.R.; Talarico C.; Spyrakis F.; Lindahl E.; Zaliani A.; Carloni P.; Wade R.C.; Musiani F.; Kokh D.B.; Rossetti G. | 2021-01-01 | ACS PHARMACOLOGY & TRANSLATIONAL SCIENCE | - | 1.01 Articolo in rivista | gossen-et-al-2021-a-blueprint-for-high-affinity-sars-cov-2-mpro-inhibitors-from-activity-based-compound-library_compressed.pdf |
| Combining Different Docking Engines and Consensus Strategies to Design and Validate Optimized Virtual Screening Protocols for the SARS-CoV-2 3CL Protease | Manelfi C.; Gossen J.; Gervasoni S.; Talarico C.; Albani S.; Philipp B.J.; Musiani F.; Vistoli G....; Rossetti G.; Beccari A.R.; Pedretti A. | 2021-01-01 | MOLECULES | - | 1.01 Articolo in rivista | 69_2021_Manelfi_Molecules.pdf |