DI STEFANO, GIUSEPPINA
DI STEFANO, GIUSEPPINA
DIMEC - DIPARTIMENTO DI SCIENZE MEDICHE E CHIRURGICHE
Docenti di ruolo di IIa fascia
Investigating synthetic lethality and PARP inhibitor resistance in pancreatic cancer through enantiomer differential activity
2025 Masi, Mirco; Poppi, Laura; Previtali, Viola; Nelson, Shannon R; Wynne, Kieran; Varignani, Giulia; Falchi, Federico; Veronesi, Marina; Albanesi, Ennio; Tedesco, Daniele; De Franco, Francesca; Ciamarone, Andrea; Myers, Samuel H; Ortega, Jose Antonio; Bagnolini, Greta; Ferrandi, Giovanni; Farabegoli, Fulvia; Tirelli, Nicola; Di Stefano, Giuseppina; Oliviero, Giorgio; Walsh, Naomi; Roberti, Marinella; Girotto, Stefania; Cavalli, Andrea
Differential enantiomers activity of ARN24089 to achieve synthetic lethality in pancreatic cancer
2024 Previtali, Viola; Masi, Mirco; Poppi, Laura; Varignani, Giulia; Falchi, Federico; Tedesco, Daniele; Wynne, Kieran; Oliviero, Giorgio; Bagnolini, Greta; Farabegoli, Fulvia; DI STEFANO, Giuseppina; Girotto, Stefania; Roberti, Marinella; Cavalli, Andrea
Lactate-Induced HBEGF Shedding and EGFR Activation: Paving the Way to a New Anticancer Therapeutic Opportunity
2024 Rossi, V.; Hochkoeppler, A.; Govoni, M.; Di Stefano, G.
Peptides inhibiting the assembly of monomeric human l‐lactate dehydrogenase into catalytically active homotetramer decrease the synthesis of lactate in cultured cells
2024 Stefan, Alessandra; Gentilucci, Luca; Ruffolo, Francesca; Rossi, Valentina; Sordi, Sofia; He, Tingting; di Stefano, Giuseppina; Santino, Federica; Brigotti, Maurizio; Scotti, Claudia; Iamele, Luisa; de Jonge, Hugo; Piaz, Fabrizio Dal; Santarcangelo, Danilo Rocco; Hochkoeppler, Alejandro
A RAD51/BRCA2 small molecule inhibitor enhances the antineoplastic effect of the PARPi talazoparib in pancreatic cancer
2023 Laura Poppi, Samuel H Myers, Viola Previtali, Francesco Rinaldi, Fulvia Farabegoli, Giuseppina Di Stefano, Naomi Walsh, Marinella Roberti, Andrea Cavalli
An 19F NMR fragment-based approach for the discovery and development of BRCA2-RAD51 inhibitors to pursuit synthetic lethality in combination with PARP inhibition in pancreatic cancer
2023 Myers, S. H.; Poppi, L.; Rinaldi, F.; Veronesi, M.; Ciamarone, A.; Previtali, V.; Bagnolini, G.; Schipani, F.; Ortega Martínez, J. A.; Girotto, S.; Di Stefano, G.; Farabegoli, F.; Walsh, N.; De Franco, F.; Roberti, M.; Cavalli, A.
Lactate Can Modulate the Antineoplastic Effects of Doxorubicin and Relieve the Drug's Oxidative Damage on Cardiomyocytes
2023 Rossi, Valentina; Govoni, Marzia; Di Stefano, Giuseppina
Lactate preserves genome integrity and extends proliferative potential in cancer cells
2023 Valentina Rossi; Marzia Govoni; Giuseppina Di Stefano
Preomic profile of BxPC-3 cells after treatment with BRC4
2023 Previtali V.; Myers S.H.; Poppi L.; Wynne K.; Casamassima I.; Girotto S.; Di Stefano G.; Farabegoli F.; Roberti M.; Oliviero G.; Cavalli A.
Proteomic profile of BxPC-3 cells after treatment with BRC4
2023 Viola Previtali, Samuel H. Myers, Laura Poppi, Kieran Wynne, Irene Casamassima Stefania Girotto, Giuseppina Di Stefano, Fulvia Farabegoli, Marinella Roberti, Giorgio Oliviero, Andrea Cavalli
Allosteric transitions of rabbit skeletal muscle lactate dehydrogenase induced by pH-dependent dissociation of the tetrameric enzyme
2022 Iacovino, L. G.; Rossi, M.; Di Stefano, G.; Rossi, V.; Binda, C.; Brigotti, M.; Tomaselli, F.; Pasti, A. P.; Dal Piaz, F.; Cerini, S.; Hochkoeppler, A.
Human lactate dehydrogenase A undergoes allosteric transitions under pH conditions inducing the dissociation of the tetrameric enzyme
2022 Pasti A.P.; Rossi V.; Di Stefano G.; Brigotti M.; Hochkoeppler A.
Identification and subsequent development of RAD51-BRCA2 disruptors through a fragment-based approach
2022 Samuel Harry Myers , Viola Previtali, Laura Poppi, Francesco Rinaldi, Fabrizio Schipani, Jose Antonio Ortega, Francesca De Franco, Marina Veronesi, Roberto Pellicciari, Marinella Roberti, Stefania Girotto, Giuseppina Di Stefano, Andrea Cavalli
Insights into the activity of ARN24089, a new RAD51-BRCA2 disruptor that inhibits homologous recombination and achieves synthetic lethality in pancreatic cancer
2022 Previtali V., Myers S. H., Bagnolini G., Poppi L., Rinaldi F., Schipani F., Ortega J. A., De Franco F., Pellicciari R., Girotto S., Oliviero G., Walsh N., Valenti G., Tirelli N., Di Stefano G., Roberti M., Cavalli A.
Lactate is a potential promoter of tamoxifen resistance in MCF7 cells
2022 Rossi V.; Govoni M.; Farabegoli F.; Di Stefano G.
The Mechanistic Understanding of RAD51 Defibrillation: A Critical Step in BRCA2-Mediated DNA Repair by Homologous Recombination
2022 Schipani, Fabrizio; Manerba, Marcella; Marotta, Roberto; Poppi, Laura; Gennari, Arianna; Rinaldi, Francesco; Armirotti, Andrea; Farabegoli, Fulvia; Roberti, Marinella; Di Stefano, Giuseppina; Rocchia, Walter; Girotto, Stefania; Tirelli, Nicola; Cavalli, Andrea
Lactate dehydrogenase inhibition affects homologous recombination repair independently of cell metabolic asset; implications for anticancer treatment
2021 Balboni, A.; Govoni, M.; Rossi, V.; Roberti, M.; Cavalli, A.; Di Stefano, G.; Manerba, M.
Lactate Upregulates the Expression of DNA Repair Genes, Causing Intrinsic Resistance of Cancer Cells to Cisplatin
2021 Govoni M.; Rossi V.; Di Stefano G.; Manerba M.
RAD51 nuclear recruitment and inhibition towards innovative strategies against pancreatic cancer
2021 Schipani, Fabrizio; Manerba, Marcella; Marotta, Roberto; Gennari, Arianna; Rinaldi, Francesco; Armirotti, Andrea; Roberti, Marinella; Di Stefano, Giuseppina; Rocchia, Walter; Tirelli, Nicola; Girotto, Stefania; Cavalli, Andrea
Synthetic Lethality in Pancreatic Cancer: Discovery of a New RAD51-BRCA2 Small Molecule Disruptor That Inhibits Homologous Recombination and Synergizes with Olaparib
2020 Bagnolini G.; Milano D.; Manerba M.; Schipani F.; Ortega J.A.; Gioia D.; Falchi F.; Balboni A.; Farabegoli F.; De Franco F.; Robertson J.; Pellicciari R.; Pallavicini I.; Peri S.; Minucci S.; Girotto S.; Di Stefano G.; Roberti M.; Cavalli A.
| Titolo | Autore(i) | Anno | Periodico | Editore | Tipo | File |
|---|---|---|---|---|---|---|
| Investigating synthetic lethality and PARP inhibitor resistance in pancreatic cancer through enantiomer differential activity | Masi, Mirco; Poppi, Laura; Previtali, Viola; Nelson, Shannon R; Wynne, Kieran; Varignani, Giulia;... Falchi, Federico; Veronesi, Marina; Albanesi, Ennio; Tedesco, Daniele; De Franco, Francesca; Ciamarone, Andrea; Myers, Samuel H; Ortega, Jose Antonio; Bagnolini, Greta; Ferrandi, Giovanni; Farabegoli, Fulvia; Tirelli, Nicola; Di Stefano, Giuseppina; Oliviero, Giorgio; Walsh, Naomi; Roberti, Marinella; Girotto, Stefania; Cavalli, Andrea | 2025-01-01 | CELL DEATH DISCOVERY | - | 1.01 Articolo in rivista | Masi_et_al-2025-Cell_Death_Discovery.pdf; 41420_2025_2382_MOESM3_ESM.xlsx; 41420_2025_2382_MOESM2_ESM.pdf; 41420_2025_2382_MOESM1_ESM.docx |
| Differential enantiomers activity of ARN24089 to achieve synthetic lethality in pancreatic cancer | Previtali, Viola; Masi, Mirco; Poppi, Laura; Varignani, Giulia; Falchi, Federico; Tedesco, Daniel...e; Wynne, Kieran; Oliviero, Giorgio; Bagnolini, Greta; Farabegoli, Fulvia; DI STEFANO, Giuseppina; Girotto, Stefania; Roberti, Marinella; Cavalli, Andrea | 2024-01-01 | - | - | 4.03 Poster | - |
| Lactate-Induced HBEGF Shedding and EGFR Activation: Paving the Way to a New Anticancer Therapeutic Opportunity | Rossi, V.; Hochkoeppler, A.; Govoni, M.; Di Stefano, G. | 2024-01-01 | CELLS | - | 1.01 Articolo in rivista | cells-13-01533-v2_compressed.pdf; cells-13-01533-s001.zip |
| Peptides inhibiting the assembly of monomeric human l‐lactate dehydrogenase into catalytically active homotetramer decrease the synthesis of lactate in cultured cells | Stefan, Alessandra; Gentilucci, Luca; Ruffolo, Francesca; Rossi, Valentina; Sordi, Sofia; He, Tin...gting; di Stefano, Giuseppina; Santino, Federica; Brigotti, Maurizio; Scotti, Claudia; Iamele, Luisa; de Jonge, Hugo; Piaz, Fabrizio Dal; Santarcangelo, Danilo Rocco; Hochkoeppler, Alejandro | 2024-01-01 | PROTEIN SCIENCE | - | 1.01 Articolo in rivista | PRO-33-e5161-s001.pdf; Protein Science - 2024 - Stefan.pdf |
| A RAD51/BRCA2 small molecule inhibitor enhances the antineoplastic effect of the PARPi talazoparib in pancreatic cancer | Laura Poppi, Samuel H Myers, Viola Previtali, Francesco Rinaldi, Fulvia Farabegoli, Giuseppina Di... Stefano, Naomi Walsh, Marinella Roberti, Andrea Cavalli | 2023-01-01 | - | FEBS PRESS | 4.03 Poster | - |
| An 19F NMR fragment-based approach for the discovery and development of BRCA2-RAD51 inhibitors to pursuit synthetic lethality in combination with PARP inhibition in pancreatic cancer | Myers, S. H.; Poppi, L.; Rinaldi, F.; Veronesi, M.; Ciamarone, A.; Previtali, V.; Bagnolini, G.; ...Schipani, F.; Ortega Martínez, J. A.; Girotto, S.; Di Stefano, G.; Farabegoli, F.; Walsh, N.; De Franco, F.; Roberti, M.; Cavalli, A. | 2023-01-01 | EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | - | 1.01 Articolo in rivista | 1-s2.0-S0223523423010814-mmc1.docx; 1-s2.0-S0223523423010814-main.pdf |
| Lactate Can Modulate the Antineoplastic Effects of Doxorubicin and Relieve the Drug's Oxidative Damage on Cardiomyocytes | Rossi, Valentina; Govoni, Marzia; Di Stefano, Giuseppina | 2023-01-01 | CANCERS | - | 1.01 Articolo in rivista | cancers-15-03728.pdf |
| Lactate preserves genome integrity and extends proliferative potential in cancer cells | Valentina Rossi; Marzia Govoni; Giuseppina Di Stefano | 2023-01-01 | - | FEBS PRESS | 4.03 Poster | - |
| Preomic profile of BxPC-3 cells after treatment with BRC4 | Previtali V.; Myers S.H.; Poppi L.; Wynne K.; Casamassima I.; Girotto S.; Di Stefano G.; Farabego...li F.; Roberti M.; Oliviero G.; Cavalli A. | 2023-01-01 | JOURNAL OF PROTEOMICS | - | 1.01 Articolo in rivista | manuscript_jprot_revised_second round_clean (1).docx |
| Proteomic profile of BxPC-3 cells after treatment with BRC4 | Viola Previtali, Samuel H. Myers, Laura Poppi, Kieran Wynne, Irene Casamassima Stefania Girotto, ...Giuseppina Di Stefano, Fulvia Farabegoli, Marinella Roberti, Giorgio Oliviero, Andrea Cavalli | 2023-01-01 | JOURNAL OF PROTEOMICS | - | 1.01 Articolo in rivista | - |
| Allosteric transitions of rabbit skeletal muscle lactate dehydrogenase induced by pH-dependent dissociation of the tetrameric enzyme | Iacovino, L. G.; Rossi, M.; Di Stefano, G.; Rossi, V.; Binda, C.; Brigotti, M.; Tomaselli, F.; Pa...sti, A. P.; Dal Piaz, F.; Cerini, S.; Hochkoeppler, A. | 2022-01-01 | BIOCHIMIE | - | 1.01 Articolo in rivista | Allosteric_compressed(1).pdf |
| Human lactate dehydrogenase A undergoes allosteric transitions under pH conditions inducing the dissociation of the tetrameric enzyme | Pasti A.P.; Rossi V.; Di Stefano G.; Brigotti M.; Hochkoeppler A. | 2022-01-01 | BIOSCIENCE REPORTS | - | 1.01 Articolo in rivista | bsr-2021-2654.pdf; BSR-2021-2654_supp.pdf |
| Identification and subsequent development of RAD51-BRCA2 disruptors through a fragment-based approach | Samuel Harry Myers , Viola Previtali, Laura Poppi, Francesco Rinaldi, Fabrizio Schipani, Jose Ant...onio Ortega, Francesca De Franco, Marina Veronesi, Roberto Pellicciari, Marinella Roberti, Stefania Girotto, Giuseppina Di Stefano, Andrea Cavalli | 2022-01-01 | - | - | 4.02 Riassunto (Abstract) | - |
| Insights into the activity of ARN24089, a new RAD51-BRCA2 disruptor that inhibits homologous recombination and achieves synthetic lethality in pancreatic cancer | Previtali V., Myers S. H., Bagnolini G., Poppi L., Rinaldi F., Schipani F., Ortega J. A., De Fran...co F., Pellicciari R., Girotto S., Oliviero G., Walsh N., Valenti G., Tirelli N., Di Stefano G., Roberti M., Cavalli A. | 2022-01-01 | - | - | 4.02 Riassunto (Abstract) | - |
| Lactate is a potential promoter of tamoxifen resistance in MCF7 cells | Rossi V.; Govoni M.; Farabegoli F.; Di Stefano G. | 2022-01-01 | BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS | - | 1.01 Articolo in rivista | Revised Manuscript.pdf |
| The Mechanistic Understanding of RAD51 Defibrillation: A Critical Step in BRCA2-Mediated DNA Repair by Homologous Recombination | Schipani, Fabrizio; Manerba, Marcella; Marotta, Roberto; Poppi, Laura; Gennari, Arianna; Rinaldi,... Francesco; Armirotti, Andrea; Farabegoli, Fulvia; Roberti, Marinella; Di Stefano, Giuseppina; Rocchia, Walter; Girotto, Stefania; Tirelli, Nicola; Cavalli, Andrea | 2022-01-01 | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | - | 1.01 Articolo in rivista | ijms-23-08338-v3 (1).pdf |
| Lactate dehydrogenase inhibition affects homologous recombination repair independently of cell metabolic asset; implications for anticancer treatment | Balboni, A.; Govoni, M.; Rossi, V.; Roberti, M.; Cavalli, A.; Di Stefano, G.; Manerba, M. | 2021-01-01 | BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS | - | 1.01 Articolo in rivista | Revised Text BBA 2020.pdf |
| Lactate Upregulates the Expression of DNA Repair Genes, Causing Intrinsic Resistance of Cancer Cells to Cisplatin | Govoni M.; Rossi V.; Di Stefano G.; Manerba M. | 2021-01-01 | PATHOLOGY ONCOLOGY RESEARCH | - | 1.01 Articolo in rivista | POR journal 2021.pdf |
| RAD51 nuclear recruitment and inhibition towards innovative strategies against pancreatic cancer | Schipani, Fabrizio; Manerba, Marcella; Marotta, Roberto; Gennari, Arianna; Rinaldi, Francesco; Ar...mirotti, Andrea; Roberti, Marinella; Di Stefano, Giuseppina; Rocchia, Walter; Tirelli, Nicola; Girotto, Stefania; Cavalli, Andrea | 2021-01-01 | bioRxiv | - | 1.01 Articolo in rivista | - |
| Synthetic Lethality in Pancreatic Cancer: Discovery of a New RAD51-BRCA2 Small Molecule Disruptor That Inhibits Homologous Recombination and Synergizes with Olaparib | Bagnolini G.; Milano D.; Manerba M.; Schipani F.; Ortega J.A.; Gioia D.; Falchi F.; Balboni A.; F...arabegoli F.; De Franco F.; Robertson J.; Pellicciari R.; Pallavicini I.; Peri S.; Minucci S.; Girotto S.; Di Stefano G.; Roberti M.; Cavalli A. | 2020-01-01 | JOURNAL OF MEDICINAL CHEMISTRY | - | 1.01 Articolo in rivista | ASAP_acs.jmedchem.9b01526.pdf |