PESSION, ANDREA
PESSION, ANDREA
DIPARTIMENTO DI SCIENZE MEDICHE E CHIRURGICHE
A. PESSION; PESSION A.; Andrea Pession
Healthcare migration in Italian paediatric haematology-oncology centres belonging to AIEOP
2024 Rondelli, Roberto; Belotti, Tamara; Masetti, Riccardo; Locatelli, Franco; Massimino, Maura; Biffi, Alessandra; Dufour, Carlo; Fagioli, Franca; Menna, Giuseppe; Biondi, Andrea; Favre, Claudio; Zecca, Marco; Santoro, Nicola; Russo, Giovanna; Perrotta, Silverio; Pession, Andrea; Prete, Arcangelo
A Case of Acrodermatitis Dysmetabolica in a Child Affected by Citrullinemia Type I: When Early Diagnosis and Timely Treatment Are Not Enough
2023 Bruni L.; Cassio A.; Di Natale V.; Baronio F.; Ortolano R.; Pession A.; Piraccini B.M.; Neri I.
A miRNA screening identifies miR-192-5p as associated with response to azacitidine and lenalidomide therapy in myelodysplastic syndromes
2023 Mongiorgi, Sara; De Stefano, Alessia; Ratti, Stefano; Indio, Valentina; Astolfi, Annalisa; Casalin, Irene; Pellagatti, Andrea; Paolini, Stefania; Parisi, Sarah; Cavo, Michele; Pession, Andrea; McCubrey, James A; Suh, Pann-Ghill; Manzoli, Lucia; Boultwood, Jacqueline; Finelli, Carlo; Cocco, Lucio; Follo, Matilde Y
Antibiotic Prophylaxis for the Prevention of Urinary Tract Infections in Children: Guideline and Recommendations from the Emilia-Romagna Pediatric Urinary Tract Infections (UTI-Ped-ER) Study Group
2023 Autore, Giovanni; Bernardi, Luca; Ghidini, Filippo; La Scola, Claudio; Berardi, Alberto; Biasucci, Giacomo; Marchetti, Federico; Pasini, Andrea; Capra, Maria Elena; Castellini, Claudia; Cioni, Vera; Cantatore, Sante; Cella, Andrea; Cusenza, Francesca; De Fanti, Alessandro; Della Casa Muttini, Elisa; Di Costanzo, Margherita; Dozza, Alessandra; Gatti, Claudia; Malaventura, Cristina; Pierantoni, Luca; Parente, Giovanni; Pelusi, Gabriella; Perrone, Serafina; Serra, Laura; Torcetta, Francesco; Valletta, Enrico; Vergine, Gianluca; Antodaro, Francesco; Bergomi, Andrea; Chiarlolanza, Jennifer; Leoni, Laura; Mazzini, Franco; Sacchetti, Roberto; Suppiej, Agnese; Iughetti, Lorenzo; Pession, Andrea; Lima, Mario; Esposito, Susanna
Antigene MYCN Silencing by BGA002 Inhibits SCLC Progression Blocking mTOR Pathway and Overcomes Multidrug Resistance
2023 Bortolotti, Sonia; Angelucci, Silvia; Montemurro, Luca; Bartolucci, Damiano; Raieli, Salvatore; Lampis, Silvia; Amadesi, Camilla; Scardovi, Annalisa; Nieddu, Giammario; Cerisoli, Lucia; Paganelli, Francesca; Chiarini, Francesca; Teti, Gabriella; Falconi, Mirella; Pession, Andrea; Hrelia, Patrizia; Tonelli, Roberto
Auxological and endocrine findings in narcolepsy type 1: seventeen-year follow-up from a pediatric endocrinology center
2023 Casale S.; Assirelli V.; Pizza F.; Balsamo A.; Gennari M.; Pession A.; Plazzi G.; Cassio A.
Body Mass Index (BMI) Is the Strongest Predictor of Systemic Hypertension and Cardiac Mass in a Cohort of Children
2023 Fabi, Marianna; Meli, Matteo; Leardini, Davide; Andreozzi, Laura; Maltoni, Giulio; Bitelli, Maria; Pierantoni, Luca; Zarbo, Chiara; Dondi, Arianna; Bertulli, Cristina; Bernardini, Luca; Pession, Andrea; Lanari, Marcello
Characterization of Perinatal Stem Cell Spheroids for the Development of Cell Therapy Strategy
2023 Francesca Paris; Pasquale Marrazzo; Valeria Pizzuti; Cosetta Marchionni; Maura Rossi; Martina Michelotti; Biljana Petrovic; Elisabetta Ciani; Giuliana Simonazzi; Andrea Pession; Laura Bonsi; Francesco Alviano
Chemotherapy-free treatment for acute promyelocytic leukemia: the pediatric view of a revolutionary tale
2023 Masetti, Riccardo; Muratore, Edoardo; Leardini, Davide; Baccelli, Francesco; Pession, Andrea; Prete, Arcangelo; Locatelli, Franco
Correlations Between Cardiac Magnetic Resonance and Myocardial Histologic Findings in Fabry Disease
2023 Ditaranto, Raffaello; Leone, Ornella; Lovato, Luigi; Niro, Fabio; Cenacchi, Giovanna; Papa, Valentina; Baldovini, Chiara; Ferracin, Manuela; Salamon, Irene; Kurdi, Hibba; Parisi, Vanda; Capelli, Irene; Pession, Andrea; Liguori, Rocco; Potena, Luciano; Seri, Marco; Martin Suarez, Sofia; Galiè, Nazzareno; Moon, James C; Biagini, Elena
Cystathionine Beta-Synthase Deficiency: Three Consecutive Cases Detected in 40 Days by Newborn Screening in Emilia Romagna (Italy) and a Comprehensive Review of the Literature
2023 Candela, Egidio; Zagariello, Michele; Di Natale, Valeria; Ortolano, Rita; Righetti, Francesca; Assirelli, Valentina; Biasucci, Giacomo; Cassio, Alessandra; Pession, Andrea; Baronio, Federico
Follicular Lymphoma Microenvironment Traits Associated with Event-Free Survival
2023 Tumedei, Maria Maddalena; Piccinini, Filippo; Azzali, Irene; Pirini, Francesca; Bravaccini, Sara; De Matteis, Serena; Agostinelli, Claudio; Castellani, Gastone; Zanoni, Michele; Cortesi, Michela; Vergani, Barbara; Leone, Biagio Eugenio; Righi, Simona; Gazzola, Anna; Casadei, Beatrice; Gentilini, Davide; Calzari, Luciano; Limarzi, Francesco; Sabattini, Elena; Pession, Andrea; Tazzari, Marcella; Bertuzzi, Clara
Gut microbiota diversity before allogeneic hematopoietic stem cell transplantation as predictor of mortality in children
2023 Masetti, Riccardo; Leardini, Davide; Muratore, Edoardo; Fabbrini, Marco; D'Amico, Federica; Zama, Daniele; Baccelli, Francesco; Gottardi, Francesca; Belotti, Tamara; Ussowicz, Marek; Fraczkiewicz, Jowita; Cesaro, Simone; Zecca, Marco; Merli, Pietro; Candela, Marco; Pession, Andrea; Locatelli, Franco; Prete, Arcangelo; Brigidi, Patrizia; Turroni, Silvia
Impact of a newly established expert clinical pharmacological advice program based on TDM results in tailoring antimicrobial therapies hospital-wide in a tertiary university hospital: findings after the first-year of implementation
2023 Cojutti, Pier Giorgio; Gatti, Milo; Bonifazi, Francesca; Caramelli, Fabio; Castelli, Andrea; Cavo, Michele; Cescon, Matteo; Corvaglia, Luigi Tommaso; Lanari, Marcello; Marinelli, Sara; Morelli, Maria Cristina; Pession, Andrea; Poggioli, Gilberto; Ramirez, Stefania; Siniscalchi, Antonio; Tonetti, Tommaso; Trevisani, Franco; Zanoni, Andrea; Zinzani, Pier Luigi; Gibertoni, Chiara; Viale, Pierluigi; Pea, Federico
Levofloxacin prophylaxis and parenteral nutrition have a detrimental effect on intestinal microbial networks in pediatric patients undergoing HSCT
2023 Fabbrini, Marco; D'Amico, Federica; Leardini, Davide; Muratore, Edoardo; Barone, Monica; Belotti, Tamara; Forchielli, Maria Luisa; Zama, Daniele; Pession, Andrea; Prete, Arcangelo; Brigidi, Patrizia; Rampelli, Simone; Candela, Marco; Turroni, Silvia; Masetti, Riccardo
Long term longitudinal follow-up of an AD-HIES cohort: the impact of early diagnosis and enrollment to IPINet centers on the natural history of Job’s syndrome
2023 Carrabba M.; Dellepiane R.M.; Cortesi M.; Baselli L.A.; Soresina A.; Cirillo E.; Giardino G.; Conti F.; Dotta L.; Finocchi A.; Cancrini C.; Milito C.; Pacillo L.; Cinicola B.L.; Cossu F.; Consolini R.; Montin D.; Quinti I.; Pession A.; Fabio G.; Pignata C.; Pietrogrande M.C.; Badolato R.
Molecular Signature of Biological Aggressiveness in Clear Cell Sarcoma of the Kidney (CCSK)
2023 Fiore, Michele; Taddia, Alberto; Indio, Valentina; Bertuccio, Salvatore Nicola; Messelodi, Daria; Serravalle, Salvatore; Bandini, Jessica; Spreafico, Filippo; Perotti, Daniela; Collini, Paola; Di Cataldo, Andrea; Pasquinelli, Gianandrea; Chiarini, Francesca; Fois, Maura; Melchionda, Fraia; Pession, Andrea; Astolfi, Annalisa
Neuronopathic Gaucher disease models reveal defects in cell growth promoted by Hippo pathway activation
2023 Messelodi, Daria; Strocchi, Silvia; Bertuccio, Salvatore Nicola; Baden, Pascale; Indio, Valentina; Giorgi, Federico M; Taddia, Alberto; Serravalle, Salvatore; Valente, Sabrina; di Fonzo, Alessio; Frattini, Emanuele; Bernardoni, Roberto; Pession, Annalisa; Grifoni, Daniela; Deleidi, Michela; Astolfi, Annalisa; Pession, Andrea
Nutrient intakes in adult and pediatric coeliac disease patients on gluten-free diet: a systematic review and meta-analysis
2023 Gessaroli, Monica; Frazzoni, Leonardo; Sikandar, Usama; Bronzetti, Gabriele; Pession, Andrea; Zagari, Rocco Maurizio; Fuccio, Lorenzo; Forchielli, Maria Luisa
Role of Nutrition in Pediatric Patients with Cancer
2023 Pedretti, Laura; Massa, Serena; Leardini, Davide; Muratore, Edoardo; Rahman, Sofia; Pession, Andrea; Esposito, Susanna; Masetti, Riccardo
| Titolo | Autore(i) | Anno | Periodico | Editore | Tipo | File |
|---|---|---|---|---|---|---|
| Healthcare migration in Italian paediatric haematology-oncology centres belonging to AIEOP | Rondelli, Roberto; Belotti, Tamara; Masetti, Riccardo; Locatelli, Franco; Massimino, Maura; Biffi..., Alessandra; Dufour, Carlo; Fagioli, Franca; Menna, Giuseppe; Biondi, Andrea; Favre, Claudio; Zecca, Marco; Santoro, Nicola; Russo, Giovanna; Perrotta, Silverio; Pession, Andrea; Prete, Arcangelo | 2024-01-01 | THE ITALIAN JOURNAL OF PEDIATRICS | - | 1.01 Articolo in rivista | s13052-024-01620-1.pdf |
| A Case of Acrodermatitis Dysmetabolica in a Child Affected by Citrullinemia Type I: When Early Diagnosis and Timely Treatment Are Not Enough | Bruni L.; Cassio A.; Di Natale V.; Baronio F.; Ortolano R.; Pession A.; Piraccini B.M.; Neri I. | 2023-01-01 | CHILDREN | - | 1.01 Articolo in rivista | - |
| A miRNA screening identifies miR-192-5p as associated with response to azacitidine and lenalidomide therapy in myelodysplastic syndromes | Mongiorgi, Sara; De Stefano, Alessia; Ratti, Stefano; Indio, Valentina; Astolfi, Annalisa; Casali...n, Irene; Pellagatti, Andrea; Paolini, Stefania; Parisi, Sarah; Cavo, Michele; Pession, Andrea; McCubrey, James A; Suh, Pann-Ghill; Manzoli, Lucia; Boultwood, Jacqueline; Finelli, Carlo; Cocco, Lucio; Follo, Matilde Y | 2023-01-01 | CLINICAL EPIGENETICS | - | 1.01 Articolo in rivista | s13148-023-01441-9.pdf; 13148_2023_1441_MOESM2_ESM.pdf; 13148_2023_1441_MOESM3_ESM (1).pdf; 13148_2023_1441_MOESM1_ESM.xlsx |
| Antibiotic Prophylaxis for the Prevention of Urinary Tract Infections in Children: Guideline and Recommendations from the Emilia-Romagna Pediatric Urinary Tract Infections (UTI-Ped-ER) Study Group | Autore, Giovanni; Bernardi, Luca; Ghidini, Filippo; La Scola, Claudio; Berardi, Alberto; Biasucci..., Giacomo; Marchetti, Federico; Pasini, Andrea; Capra, Maria Elena; Castellini, Claudia; Cioni, Vera; Cantatore, Sante; Cella, Andrea; Cusenza, Francesca; De Fanti, Alessandro; Della Casa Muttini, Elisa; Di Costanzo, Margherita; Dozza, Alessandra; Gatti, Claudia; Malaventura, Cristina; Pierantoni, Luca; Parente, Giovanni; Pelusi, Gabriella; Perrone, Serafina; Serra, Laura; Torcetta, Francesco; Valletta, Enrico; Vergine, Gianluca; Antodaro, Francesco; Bergomi, Andrea; Chiarlolanza, Jennifer; Leoni, Laura; Mazzini, Franco; Sacchetti, Roberto; Suppiej, Agnese; Iughetti, Lorenzo; Pession, Andrea; Lima, Mario; Esposito, Susanna | 2023-01-01 | ANTIBIOTICS | - | 1.01 Articolo in rivista | 410 antibiotic prophylaxis for the prevention of urinary tract infections in children guideline and recommendations from the emiliaromagna pediatric urinary tract infections UTI Ped ER study grou.pdf; antibiotics-12-01040-s001.zip |
| Antigene MYCN Silencing by BGA002 Inhibits SCLC Progression Blocking mTOR Pathway and Overcomes Multidrug Resistance | Bortolotti, Sonia; Angelucci, Silvia; Montemurro, Luca; Bartolucci, Damiano; Raieli, Salvatore; L...ampis, Silvia; Amadesi, Camilla; Scardovi, Annalisa; Nieddu, Giammario; Cerisoli, Lucia; Paganelli, Francesca; Chiarini, Francesca; Teti, Gabriella; Falconi, Mirella; Pession, Andrea; Hrelia, Patrizia; Tonelli, Roberto | 2023-01-01 | CANCERS | - | 1.01 Articolo in rivista | cancers-15-00990.pdf |
| Auxological and endocrine findings in narcolepsy type 1: seventeen-year follow-up from a pediatric endocrinology center | Casale S.; Assirelli V.; Pizza F.; Balsamo A.; Gennari M.; Pession A.; Plazzi G.; Cassio A. | 2023-01-01 | FRONTIERS IN ENDOCRINOLOGY | - | 1.01 Articolo in rivista | fendo-14-1037398.pdf |
| Body Mass Index (BMI) Is the Strongest Predictor of Systemic Hypertension and Cardiac Mass in a Cohort of Children | Fabi, Marianna; Meli, Matteo; Leardini, Davide; Andreozzi, Laura; Maltoni, Giulio; Bitelli, Maria...; Pierantoni, Luca; Zarbo, Chiara; Dondi, Arianna; Bertulli, Cristina; Bernardini, Luca; Pession, Andrea; Lanari, Marcello | 2023-01-01 | NUTRIENTS | - | 1.01 Articolo in rivista | nutrients-15-05079.pdf; nutrients-15-05079-s001.zip |
| Characterization of Perinatal Stem Cell Spheroids for the Development of Cell Therapy Strategy | Francesca Paris; Pasquale Marrazzo; Valeria Pizzuti; Cosetta Marchionni; Maura Rossi; Martina Mic...helotti; Biljana Petrovic; Elisabetta Ciani; Giuliana Simonazzi; Andrea Pession; Laura Bonsi; Francesco Alviano | 2023-01-01 | BIOENGINEERING | - | 1.01 Articolo in rivista | Bioengineering 2023, 10(2), 189;.pdf |
| Chemotherapy-free treatment for acute promyelocytic leukemia: the pediatric view of a revolutionary tale | Masetti, Riccardo; Muratore, Edoardo; Leardini, Davide; Baccelli, Francesco; Pession, Andrea; Pre...te, Arcangelo; Locatelli, Franco | 2023-01-01 | FRONTIERS IN ONCOLOGY | - | 1.01 Articolo in rivista | fonc-13-1135350.pdf |
| Correlations Between Cardiac Magnetic Resonance and Myocardial Histologic Findings in Fabry Disease | Ditaranto, Raffaello; Leone, Ornella; Lovato, Luigi; Niro, Fabio; Cenacchi, Giovanna; Papa, Valen...tina; Baldovini, Chiara; Ferracin, Manuela; Salamon, Irene; Kurdi, Hibba; Parisi, Vanda; Capelli, Irene; Pession, Andrea; Liguori, Rocco; Potena, Luciano; Seri, Marco; Martin Suarez, Sofia; Galiè, Nazzareno; Moon, James C; Biagini, Elena | 2023-01-01 | JACC. CARDIOVASCULAR IMAGING | - | 1.01 Articolo in rivista | Correlations Between Cardiac Magnetic.pdf |
| Cystathionine Beta-Synthase Deficiency: Three Consecutive Cases Detected in 40 Days by Newborn Screening in Emilia Romagna (Italy) and a Comprehensive Review of the Literature | Candela, Egidio; Zagariello, Michele; Di Natale, Valeria; Ortolano, Rita; Righetti, Francesca; As...sirelli, Valentina; Biasucci, Giacomo; Cassio, Alessandra; Pession, Andrea; Baronio, Federico | 2023-01-01 | CHILDREN | - | 1.01 Articolo in rivista | children-10-00396.pdf |
| Follicular Lymphoma Microenvironment Traits Associated with Event-Free Survival | Tumedei, Maria Maddalena; Piccinini, Filippo; Azzali, Irene; Pirini, Francesca; Bravaccini, Sara;... De Matteis, Serena; Agostinelli, Claudio; Castellani, Gastone; Zanoni, Michele; Cortesi, Michela; Vergani, Barbara; Leone, Biagio Eugenio; Righi, Simona; Gazzola, Anna; Casadei, Beatrice; Gentilini, Davide; Calzari, Luciano; Limarzi, Francesco; Sabattini, Elena; Pession, Andrea; Tazzari, Marcella; Bertuzzi, Clara | 2023-01-01 | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | - | 1.01 Articolo in rivista | 0074_2023_IntJoMolecularSciences_Tumedei.pdf |
| Gut microbiota diversity before allogeneic hematopoietic stem cell transplantation as predictor of mortality in children | Masetti, Riccardo; Leardini, Davide; Muratore, Edoardo; Fabbrini, Marco; D'Amico, Federica; Zama,... Daniele; Baccelli, Francesco; Gottardi, Francesca; Belotti, Tamara; Ussowicz, Marek; Fraczkiewicz, Jowita; Cesaro, Simone; Zecca, Marco; Merli, Pietro; Candela, Marco; Pession, Andrea; Locatelli, Franco; Prete, Arcangelo; Brigidi, Patrizia; Turroni, Silvia | 2023-01-01 | BLOOD | - | 1.01 Articolo in rivista | PageProof_BLOOD_1725.pdf |
| Impact of a newly established expert clinical pharmacological advice program based on TDM results in tailoring antimicrobial therapies hospital-wide in a tertiary university hospital: findings after the first-year of implementation | Cojutti, Pier Giorgio; Gatti, Milo; Bonifazi, Francesca; Caramelli, Fabio; Castelli, Andrea; Cavo..., Michele; Cescon, Matteo; Corvaglia, Luigi Tommaso; Lanari, Marcello; Marinelli, Sara; Morelli, Maria Cristina; Pession, Andrea; Poggioli, Gilberto; Ramirez, Stefania; Siniscalchi, Antonio; Tonetti, Tommaso; Trevisani, Franco; Zanoni, Andrea; Zinzani, Pier Luigi; Gibertoni, Chiara; Viale, Pierluigi; Pea, Federico | 2023-01-01 | INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS | - | 1.01 Articolo in rivista | 1-s2.0-S0924857923001632-main.pdf |
| Levofloxacin prophylaxis and parenteral nutrition have a detrimental effect on intestinal microbial networks in pediatric patients undergoing HSCT | Fabbrini, Marco; D'Amico, Federica; Leardini, Davide; Muratore, Edoardo; Barone, Monica; Belotti,... Tamara; Forchielli, Maria Luisa; Zama, Daniele; Pession, Andrea; Prete, Arcangelo; Brigidi, Patrizia; Rampelli, Simone; Candela, Marco; Turroni, Silvia; Masetti, Riccardo | 2023-01-01 | COMMUNICATIONS BIOLOGY | - | 1.01 Articolo in rivista | Fabbrini 2023 CommsBio - Levofloxacin prophylaxis and parenteral nutrition have a detrimental effect on intestinal microbial networks in pediatric patients undergoing HSCT.pdf |
| Long term longitudinal follow-up of an AD-HIES cohort: the impact of early diagnosis and enrollment to IPINet centers on the natural history of Job’s syndrome | Carrabba M.; Dellepiane R.M.; Cortesi M.; Baselli L.A.; Soresina A.; Cirillo E.; Giardino G.; Con...ti F.; Dotta L.; Finocchi A.; Cancrini C.; Milito C.; Pacillo L.; Cinicola B.L.; Cossu F.; Consolini R.; Montin D.; Quinti I.; Pession A.; Fabio G.; Pignata C.; Pietrogrande M.C.; Badolato R. | 2023-01-01 | ALLERGY, ASTHMA, AND CLINICAL IMMUNOLOGY | - | 1.01 Articolo in rivista | 13223_2023_Article_776.pdf; 13223_2023_776_MOESM1_ESM.xlsx |
| Molecular Signature of Biological Aggressiveness in Clear Cell Sarcoma of the Kidney (CCSK) | Fiore, Michele; Taddia, Alberto; Indio, Valentina; Bertuccio, Salvatore Nicola; Messelodi, Daria;... Serravalle, Salvatore; Bandini, Jessica; Spreafico, Filippo; Perotti, Daniela; Collini, Paola; Di Cataldo, Andrea; Pasquinelli, Gianandrea; Chiarini, Francesca; Fois, Maura; Melchionda, Fraia; Pession, Andrea; Astolfi, Annalisa | 2023-01-01 | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | - | 1.01 Articolo in rivista | ijms-24-03743-v2 (2).pdf; ijms-24-03743-s001.zip |
| Neuronopathic Gaucher disease models reveal defects in cell growth promoted by Hippo pathway activation | Messelodi, Daria; Strocchi, Silvia; Bertuccio, Salvatore Nicola; Baden, Pascale; Indio, Valentina...; Giorgi, Federico M; Taddia, Alberto; Serravalle, Salvatore; Valente, Sabrina; di Fonzo, Alessio; Frattini, Emanuele; Bernardoni, Roberto; Pession, Annalisa; Grifoni, Daniela; Deleidi, Michela; Astolfi, Annalisa; Pession, Andrea | 2023-01-01 | COMMUNICATIONS BIOLOGY | - | 1.01 Articolo in rivista | Hippo_Gaucher.pdf; 42003.zip |
| Nutrient intakes in adult and pediatric coeliac disease patients on gluten-free diet: a systematic review and meta-analysis | Gessaroli, Monica; Frazzoni, Leonardo; Sikandar, Usama; Bronzetti, Gabriele; Pession, Andrea; Zag...ari, Rocco Maurizio; Fuccio, Lorenzo; Forchielli, Maria Luisa | 2023-01-01 | EUROPEAN JOURNAL OF CLINICAL NUTRITION | - | 1.01 Articolo in rivista | - |
| Role of Nutrition in Pediatric Patients with Cancer | Pedretti, Laura; Massa, Serena; Leardini, Davide; Muratore, Edoardo; Rahman, Sofia; Pession, Andr...ea; Esposito, Susanna; Masetti, Riccardo | 2023-01-01 | NUTRIENTS | - | 1.01 Articolo in rivista | nutrients-15-00710-v2.pdf |