Managing Multiorgan Failure in Acute on Chronic Liver Failure

Acute-on-chronic liver failure (ACLF) is defined as a clinical syndrome that develops in patients with chronic liver disease characterized by the presence of organ failure and high short-term mortality, although there is still no worldwide consensus on diagnostic criteria. Management of ACLF is mainly based on treatment of "precipitating factors" (the most common are infections, alcohol-associated hepatitis, hepatitis B flare, and bleeding) and support of organ failure, which often requires admission to the intensive care unit. Liver transplantation should be considered in patients with ACLF grade 2-3 as a potentially life-saving treatment. When transplant is not indicated, palliative care should be considered after 3-7 days of full organ support in patients with at least 4 organ failures or a CLIF-C ACLF score >70. This review summarizes the current knowledge on the management of organ failure in patients with ACLF, focusing on recent advances.