The cerebral cortex exhibits an intrinsic structural complexity of folding. Fractal geometry may be used to describe the structural complexity of objects (such as the cerebral cortex) that show self-similarity throughout a proper range of spatial scales. The potential value of fractal dimension, estimated from T1-weighted MRI images, has already been widely demonstrated in previous literature, but how it is related to the cyto- and myeloarchitecture of the cerebral cortex is still unknown. In this study, we computed the fractal dimension of the six cortical layers, which present various cellular compositions and distributions, developmental trajectories, connections, physiology, and functional roles. The procedure for determining fractal dimension indices was applied to segmentations obtained from the public BigBrain dataset that consists of an ultrahigh-resolution three-dimensional (3D) model of a human brain based on histologically processed postmortem brain reconstruction. Results denote an increasing trend in fractal dimension values from the outermost (layer I) to the innermost layers (the infragranular layers V and VI) of the cortex in both hemispheres. Layers V and VI are composed of sparse, low-density pyramidal neurons and fusiform cells. Differently from the supragranular layers (i.e., layers I, II, and III), the infragranular layers are characterized by a high content of myelin belonging to the projection fibers. Consequently, the structural complexity of the cerebral cortex seems to be coupled with the projection fibers network, rather than with neuronal density, and the presence of associative and commissural fibers.

Giorgini F., Diciotti S., Marzi C. (2023). The hidden structural complexity of the human cerebral cortex. Patron Editore S.r.l..

The hidden structural complexity of the human cerebral cortex

Diciotti S.;Marzi C.
2023

Abstract

The cerebral cortex exhibits an intrinsic structural complexity of folding. Fractal geometry may be used to describe the structural complexity of objects (such as the cerebral cortex) that show self-similarity throughout a proper range of spatial scales. The potential value of fractal dimension, estimated from T1-weighted MRI images, has already been widely demonstrated in previous literature, but how it is related to the cyto- and myeloarchitecture of the cerebral cortex is still unknown. In this study, we computed the fractal dimension of the six cortical layers, which present various cellular compositions and distributions, developmental trajectories, connections, physiology, and functional roles. The procedure for determining fractal dimension indices was applied to segmentations obtained from the public BigBrain dataset that consists of an ultrahigh-resolution three-dimensional (3D) model of a human brain based on histologically processed postmortem brain reconstruction. Results denote an increasing trend in fractal dimension values from the outermost (layer I) to the innermost layers (the infragranular layers V and VI) of the cortex in both hemispheres. Layers V and VI are composed of sparse, low-density pyramidal neurons and fusiform cells. Differently from the supragranular layers (i.e., layers I, II, and III), the infragranular layers are characterized by a high content of myelin belonging to the projection fibers. Consequently, the structural complexity of the cerebral cortex seems to be coupled with the projection fibers network, rather than with neuronal density, and the presence of associative and commissural fibers.
2023
Convegno Nazionale di Bioingegneria
1
4
Giorgini F., Diciotti S., Marzi C. (2023). The hidden structural complexity of the human cerebral cortex. Patron Editore S.r.l..
Giorgini F.; Diciotti S.; Marzi C.
File in questo prodotto:
Eventuali allegati, non sono esposti

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11585/964542
 Attenzione

Attenzione! I dati visualizzati non sono stati sottoposti a validazione da parte dell'ateneo

Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus 0
  • ???jsp.display-item.citation.isi??? ND
social impact