The relationship between genetic liability, childhood maltreatment, and IQ: findings from the EU-GEI multicentric case–control study

Sideli, L.; Aas, M.; Quattrone, D.; La Barbera, D.; La Cascia, C.; Ferraro, L.; Alameda, L.; Velthorst, E.; Trotta, G.; Tripoli, G.; Schimmenti, A.; Fontana, A.; Gayer-Anderson, C.; Stilo, S.; Seminerio, F.; Sartorio, C.; Marrazzo, G.; Lasalvia, A.; Tosato, S.; Tarricone, I.; Berardi, D.; D'Andrea, G.; Amoretti, S.; Andreu-Bernabeu, A.; Baudin, G.; Beards, S.; Bonetto, C.; Bonora, E.; Cabrera, B.; Carracedo, A.; Charpeaud, T.; Costas, J.; Cristofalo, D.; Cuadrado, P.; Duran-Cutilla, M.; Ferchiou, A.; Fraguas, D.; Franke, N.; Frijda, F.; Garcia-Portilla, P.; Gonzalez Penas, J.; Hubbard, K.; Jamain, S.; Jimenez-Lopez, E.; Leboyer, M.; Llorente, C.; Lopez Montoya, G.; Lorente-Rovira, E.; M. Diaz-Caneja C.,; Marcelino Loureiro, C.; Matteis, M.; Messchaart, E.; Molto, M. D.; Mezquida, G.; Moreno, C.; Muratori, R.; Nacher, J.; Parellada, M.; Rapado-Castro, M.; Ruggeri, M.; Richard, J. -R.; Rodriguez Solano, J. J.; Saiz, P. A.; Sanchez-Gutierrez, T.; Sanchez, E.; Schurhoff, F.; Seri, M.; Shuhama, R.; Termorshuizen, F.; Tronche, A. -M.; van Dam, D.; van der Ven, E.; Arango, C.; Arrojo, M.; Bernardo, M.; Bobes, J.; Sanjuan, J.; Santos, J. L.; Menezes, P. R.; Del-Ben, C. M.; Jongsma, H. E.; Jones, P. B.; Kirkbride, J. B.; Llorca, P. -M.; Tortelli, A.; Pignon, B.; de Haan, L.; Selten, J. -P.; Van Os, J.; Rutten, B. P.; Bentall, R.; Di Forti, M.; Murray, R. M.; Morgan, C.; Fisher, H. L.

doi:10.1007/s00127-023-02513-0

This study investigated if the association between childhood maltreatment and cognition among psychosis patients and community controls was partially accounted for by genetic liability for psychosis. Patients with first-episode psychosis (N = 755) and unaffected controls (N = 1219) from the EU-GEI study were assessed for childhood maltreatment, intelligence quotient (IQ), family history of psychosis (FH), and polygenic risk score for schizophrenia (SZ-PRS). Controlling for FH and SZ-PRS did not attenuate the association between childhood maltreatment and IQ in cases or controls. Findings suggest that these expressions of genetic liability cannot account for the lower levels of cognition found among adults maltreated in childhood.

Sideli L., Aas M., Quattrone D., La Barbera D., La Cascia C., Ferraro L., et al. (2023). The relationship between genetic liability, childhood maltreatment, and IQ: findings from the EU-GEI multicentric case–control study. SOCIAL PSYCHIATRY AND PSYCHIATRIC EPIDEMIOLOGY, 58(10), 1573-1580 [10.1007/s00127-023-02513-0].