Background: Venous thromboembolism (VTE) is a complication of COVID-19 in hospitalized patients. Little information is available on long-term outcomes of VTE in this population.Objectives: We aimed to compare the characteristics, management strategies, and long-term clinical outcomes between patients with COVID-19-associated VTE and patients with VTE provoked by hospitalization for other acute medical illnesses.Methods: This is an observational cohort study, with a prospective cohort of 278 patients with COVID-19-associated VTE enrolled between 2020 and 2021 and a comparison cohort of 300 patients without COVID-19 enrolled in the ongoing START2-Register between 2018 and 2020. Exclusion criteria included age <18 years, other indications to anticoagulant treatment, active cancer, recent (<3 months) major surgery, trauma, pregnancy, and participation in interventional studies. All patients were followed up for a minimum of 12 months after treatment discontinuation. Primary end point was the occurrence of venous and arterial thrombotic events.Results: Patients with VTE secondary to COVID-19 had more frequent pulmonary embolism without deep vein thrombosis than controls (83.1% vs 46.2%, P <.001), lower prevalence of chronic inflammatory disease (1.4% and 16.3%, P <.001), and history of VTE (5.0% and 19.0%, P <.001). The median duration of anticoagulant treatment (194 and 225 days, P = 0.9) and the proportion of patients who discontinued anticoagulation (78.0% and 75.0%, P = 0.4) were similar between the 2 groups. Thrombotic event rates after discontinuation were 1.5 and 2.6 per 100 patient-years, respectively (P = 0.4). Conclusion: The risk of recurrent thrombotic events in patients with COVID-19- associated VTE is low and similar to the risk observed in patients with VTE secondary to hospitalization for other medical diseases.

Venous thromboembolism secondary to hospitalization for COVID-19: patient management and long-term outcomes / Ageno, Walter; Antonucci, Emilia; Poli, Daniela; Bucherini, Eugenio; Chistolini, Antonio; Fregoni, Vittorio; Lerede, Teresa; Pancani, Roberta; Pedrini, Simona; Pieralli, Filippo; Pignatelli, Pasquale; Pizzini, Attilia Maria; Podda, Gian Marco; Potere, Nicola; Sarti, Luca; Testa, Sophie; Visonà, Adriana; Palareti, Gualtiero; Ageno, Walter; Girardi, Laura; Sterpone, Paola; Cosmi, Benilde; Bucherini, Eugenio; Chistolini, Antonio; Serrao, Alessandra; Di Nisio, Marcello; Potere, Nicola; Porreca, Ettore; Fregoni, Vittorio; Grandone, Elvira; Colaizzo, Donatella; Insana, Antonio; Lerede, Teresa; Falanga, Anna; Martinelli, Ida; Bucciarelli, Paolo; Abbattista, Maria; Martini, Giuliana; Masciocco, Lucilla; Mastroiacovo, Daniela; Pancani, Roberta; Carrozzi, Laura; Paparo, Carmelo; Pedrini, Simona; Pieralli, Filippo; Milia, Alessandro; Pignatelli, Pasquale; Menichelli, Danilo; Pizzini, Attilia Maria; Silingardi, Mauro; Podda, GianMarco; Birocchi, Simone; Poli, Daniela; Crudele, Felice; Lotti, Elena; Marcucci, Rossella; Preti, Paola Stefania; Sarti, Luca; Trovati, Alice; Caronna, Antonella; Famiglietti, Elena; Lami, Francesca; Nicolini, Alberto; Scaglioni, Federica; Testa, Sophie; Paoletti, Oriana; Tosetto, Alberto; Toma, Andrea; Villalta, Sabina; Visonà, Adriana; Zalunardo, Beniamino; Panzavolta, Chiara. - In: RESEARCH AND PRACTICE IN THROMBOSIS AND HAEMOSTASIS. - ISSN 2475-0379. - STAMPA. - 7:4(2023), pp. e100167.1-e100167.8. [10.1016/j.rpth.2023.100167]

Venous thromboembolism secondary to hospitalization for COVID-19: patient management and long-term outcomes

Palareti, Gualtiero;Cosmi, Benilde;
2023

Abstract

Background: Venous thromboembolism (VTE) is a complication of COVID-19 in hospitalized patients. Little information is available on long-term outcomes of VTE in this population.Objectives: We aimed to compare the characteristics, management strategies, and long-term clinical outcomes between patients with COVID-19-associated VTE and patients with VTE provoked by hospitalization for other acute medical illnesses.Methods: This is an observational cohort study, with a prospective cohort of 278 patients with COVID-19-associated VTE enrolled between 2020 and 2021 and a comparison cohort of 300 patients without COVID-19 enrolled in the ongoing START2-Register between 2018 and 2020. Exclusion criteria included age <18 years, other indications to anticoagulant treatment, active cancer, recent (<3 months) major surgery, trauma, pregnancy, and participation in interventional studies. All patients were followed up for a minimum of 12 months after treatment discontinuation. Primary end point was the occurrence of venous and arterial thrombotic events.Results: Patients with VTE secondary to COVID-19 had more frequent pulmonary embolism without deep vein thrombosis than controls (83.1% vs 46.2%, P <.001), lower prevalence of chronic inflammatory disease (1.4% and 16.3%, P <.001), and history of VTE (5.0% and 19.0%, P <.001). The median duration of anticoagulant treatment (194 and 225 days, P = 0.9) and the proportion of patients who discontinued anticoagulation (78.0% and 75.0%, P = 0.4) were similar between the 2 groups. Thrombotic event rates after discontinuation were 1.5 and 2.6 per 100 patient-years, respectively (P = 0.4). Conclusion: The risk of recurrent thrombotic events in patients with COVID-19- associated VTE is low and similar to the risk observed in patients with VTE secondary to hospitalization for other medical diseases.
2023
Venous thromboembolism secondary to hospitalization for COVID-19: patient management and long-term outcomes / Ageno, Walter; Antonucci, Emilia; Poli, Daniela; Bucherini, Eugenio; Chistolini, Antonio; Fregoni, Vittorio; Lerede, Teresa; Pancani, Roberta; Pedrini, Simona; Pieralli, Filippo; Pignatelli, Pasquale; Pizzini, Attilia Maria; Podda, Gian Marco; Potere, Nicola; Sarti, Luca; Testa, Sophie; Visonà, Adriana; Palareti, Gualtiero; Ageno, Walter; Girardi, Laura; Sterpone, Paola; Cosmi, Benilde; Bucherini, Eugenio; Chistolini, Antonio; Serrao, Alessandra; Di Nisio, Marcello; Potere, Nicola; Porreca, Ettore; Fregoni, Vittorio; Grandone, Elvira; Colaizzo, Donatella; Insana, Antonio; Lerede, Teresa; Falanga, Anna; Martinelli, Ida; Bucciarelli, Paolo; Abbattista, Maria; Martini, Giuliana; Masciocco, Lucilla; Mastroiacovo, Daniela; Pancani, Roberta; Carrozzi, Laura; Paparo, Carmelo; Pedrini, Simona; Pieralli, Filippo; Milia, Alessandro; Pignatelli, Pasquale; Menichelli, Danilo; Pizzini, Attilia Maria; Silingardi, Mauro; Podda, GianMarco; Birocchi, Simone; Poli, Daniela; Crudele, Felice; Lotti, Elena; Marcucci, Rossella; Preti, Paola Stefania; Sarti, Luca; Trovati, Alice; Caronna, Antonella; Famiglietti, Elena; Lami, Francesca; Nicolini, Alberto; Scaglioni, Federica; Testa, Sophie; Paoletti, Oriana; Tosetto, Alberto; Toma, Andrea; Villalta, Sabina; Visonà, Adriana; Zalunardo, Beniamino; Panzavolta, Chiara. - In: RESEARCH AND PRACTICE IN THROMBOSIS AND HAEMOSTASIS. - ISSN 2475-0379. - STAMPA. - 7:4(2023), pp. e100167.1-e100167.8. [10.1016/j.rpth.2023.100167]
Ageno, Walter; Antonucci, Emilia; Poli, Daniela; Bucherini, Eugenio; Chistolini, Antonio; Fregoni, Vittorio; Lerede, Teresa; Pancani, Roberta; Pedrini, Simona; Pieralli, Filippo; Pignatelli, Pasquale; Pizzini, Attilia Maria; Podda, Gian Marco; Potere, Nicola; Sarti, Luca; Testa, Sophie; Visonà, Adriana; Palareti, Gualtiero; Ageno, Walter; Girardi, Laura; Sterpone, Paola; Cosmi, Benilde; Bucherini, Eugenio; Chistolini, Antonio; Serrao, Alessandra; Di Nisio, Marcello; Potere, Nicola; Porreca, Ettore; Fregoni, Vittorio; Grandone, Elvira; Colaizzo, Donatella; Insana, Antonio; Lerede, Teresa; Falanga, Anna; Martinelli, Ida; Bucciarelli, Paolo; Abbattista, Maria; Martini, Giuliana; Masciocco, Lucilla; Mastroiacovo, Daniela; Pancani, Roberta; Carrozzi, Laura; Paparo, Carmelo; Pedrini, Simona; Pieralli, Filippo; Milia, Alessandro; Pignatelli, Pasquale; Menichelli, Danilo; Pizzini, Attilia Maria; Silingardi, Mauro; Podda, GianMarco; Birocchi, Simone; Poli, Daniela; Crudele, Felice; Lotti, Elena; Marcucci, Rossella; Preti, Paola Stefania; Sarti, Luca; Trovati, Alice; Caronna, Antonella; Famiglietti, Elena; Lami, Francesca; Nicolini, Alberto; Scaglioni, Federica; Testa, Sophie; Paoletti, Oriana; Tosetto, Alberto; Toma, Andrea; Villalta, Sabina; Visonà, Adriana; Zalunardo, Beniamino; Panzavolta, Chiara
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11585/963743
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