A 36-year-old woman presented with intermenstrual spotting and was found to have a cystic mass involving the uterine cervix on a pelvic ultrasound examination. A necrotic and hemorragic tumor was excised by hysterectomy and processed for light and electron microscopic investigation and molecular analysis. Microscopic examination revealed a small round cell tumor that immunohistochemical studies (including staining for the highly restricted surface antigen p30/32(MIC2)) and ultrastructural studies indicated was an extraosseous Ewing's sarcoma (EES)/primitive neuroectodermal tumor (PNET). This diagnosis was established by detection of EWS/ERG fusion transcript through reverse transcription polymerase chain reaction (RT-PCR) with nested primers. Full body computed tomography failed to detect any extrauterine tumor, and the patient is clinically free of disease 18 months after hysterectomy. This case represents the first report of a primary EES/PNET arising in the uterine cervix.
Primary endocervical extraosseous Ewing's sarcoma/PNET / Cenacchi G.; Pasquinelli G.; Montanaro L.; Cerasoli S.; Vici M.; Bisceglia M.; Giangaspero F.; Martinelli G.N.; Derenzini M.. - In: INTERNATIONAL JOURNAL OF GYNECOLOGICAL PATHOLOGY. - ISSN 0277-1691. - STAMPA. - 17:1(1998), pp. 83-88. [10.1097/00004347-199801000-00015]
Primary endocervical extraosseous Ewing's sarcoma/PNET
Cenacchi G.;Pasquinelli G.;Montanaro L.;Vici M.;Giangaspero F.;Martinelli G. N.;Derenzini M.
1998
Abstract
A 36-year-old woman presented with intermenstrual spotting and was found to have a cystic mass involving the uterine cervix on a pelvic ultrasound examination. A necrotic and hemorragic tumor was excised by hysterectomy and processed for light and electron microscopic investigation and molecular analysis. Microscopic examination revealed a small round cell tumor that immunohistochemical studies (including staining for the highly restricted surface antigen p30/32(MIC2)) and ultrastructural studies indicated was an extraosseous Ewing's sarcoma (EES)/primitive neuroectodermal tumor (PNET). This diagnosis was established by detection of EWS/ERG fusion transcript through reverse transcription polymerase chain reaction (RT-PCR) with nested primers. Full body computed tomography failed to detect any extrauterine tumor, and the patient is clinically free of disease 18 months after hysterectomy. This case represents the first report of a primary EES/PNET arising in the uterine cervix.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
