Isolated REM Sleep Behavior Disorder (iRBD) is the strongest prodromal marker for α-synucleinopathies. Overt α-synucleinopathies and aging share several mechanisms, but this relationship has been poorly investigated in prodromal phases. Using DNA methylation-based epigenetic clocks, we measured biological aging in videopolysomnography confirmed iRBD patients, videopolysomnography-negative and population-based controls. We found that iRBDs tended to be epigenetically older than controls, suggesting that accelerated aging characterizes prodromal neurodegeneration.
Baldelli L., Pirazzini C., Sambati L., Ravaioli F., Gentilini D., Calandra Buonaura G., et al. (2023). Epigenetic clocks suggest accelerated aging in patients with isolated REM Sleep Behavior Disorder. NPJ PARKINSON'S DISEASE, 9(1), 48-48 [10.1038/s41531-023-00492-2].
Epigenetic clocks suggest accelerated aging in patients with isolated REM Sleep Behavior Disorder
Baldelli L.;Pirazzini C.;Sambati L.;Ravaioli F.;Calandra Buonaura G.;Guaraldi P.;Franceschi C.;Cortelli P.;Garagnani P.;Bacalini M. G.;Provini F.
2023
Abstract
Isolated REM Sleep Behavior Disorder (iRBD) is the strongest prodromal marker for α-synucleinopathies. Overt α-synucleinopathies and aging share several mechanisms, but this relationship has been poorly investigated in prodromal phases. Using DNA methylation-based epigenetic clocks, we measured biological aging in videopolysomnography confirmed iRBD patients, videopolysomnography-negative and population-based controls. We found that iRBDs tended to be epigenetically older than controls, suggesting that accelerated aging characterizes prodromal neurodegeneration.| File | Dimensione | Formato | |
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