Angiosarcomas (ASs) are rare malignant vascular entities that can affect several regions in our body, including the heart. Cardiac ASs comprise 25-40% of cardiac sarcomas and can cause death within months of diagnosis. Thus, our aim was to identify potential differences and/or similarities between cardiac and extra-cardiac ASs to enhance targeted therapies and, consequently, patients' prognosis. Whole-transcriptome analysis of three cardiac and eleven extra-cardiac non-cutaneous samples was performed to investigate differential gene expression and mutational events between the two groups. The gene signature of cardiac and extra-cardiac non-cutaneous ASs was also compared to that of cutaneous angiosarcomas (n = 9). H/N/K-RAS and TP53 alterations were more recurrent in extra-cardiac ASs, while POTE-gene family overexpression was peculiar to cardiac ASs. Additionally, in vitro functional analyses showed that POTEH upregulation conferred a growth advantage to recipient cells, partly supporting the cardiac AS aggressive phenotype and patients' scarce survival rate. These features should be considered when investigating alternative treatments.

Genomic Landscape Comparison of Cardiac versus Extra-Cardiac Angiosarcomas / Gozzellino, Livia; Nannini, Margherita; Urbini, Milena; Pizzi, Carmine; Leone, Ornella; Corti, Barbara; Baldovini, Chiara; Angeli, Francesco; Foà, Alberto; Pacini, Davide; Folesani, Gianluca; Costa, Alice; Palumbo, Teresa; Nigro, Maria Concetta; Pasquinelli, Gianandrea; Astolfi, Annalisa; Pantaleo, Maria Abbondanza. - In: BIOMEDICINES. - ISSN 2227-9059. - ELETTRONICO. - 11:12(2023), pp. 3290.1-3290.14. [10.3390/biomedicines11123290]

Genomic Landscape Comparison of Cardiac versus Extra-Cardiac Angiosarcomas

Gozzellino, Livia;Nannini, Margherita;Pizzi, Carmine;Baldovini, Chiara;Angeli, Francesco;Pacini, Davide;Folesani, Gianluca;Costa, Alice;Palumbo, Teresa;Nigro, Maria Concetta;Pasquinelli, Gianandrea;Astolfi, Annalisa;Pantaleo, Maria Abbondanza
2023

Abstract

Angiosarcomas (ASs) are rare malignant vascular entities that can affect several regions in our body, including the heart. Cardiac ASs comprise 25-40% of cardiac sarcomas and can cause death within months of diagnosis. Thus, our aim was to identify potential differences and/or similarities between cardiac and extra-cardiac ASs to enhance targeted therapies and, consequently, patients' prognosis. Whole-transcriptome analysis of three cardiac and eleven extra-cardiac non-cutaneous samples was performed to investigate differential gene expression and mutational events between the two groups. The gene signature of cardiac and extra-cardiac non-cutaneous ASs was also compared to that of cutaneous angiosarcomas (n = 9). H/N/K-RAS and TP53 alterations were more recurrent in extra-cardiac ASs, while POTE-gene family overexpression was peculiar to cardiac ASs. Additionally, in vitro functional analyses showed that POTEH upregulation conferred a growth advantage to recipient cells, partly supporting the cardiac AS aggressive phenotype and patients' scarce survival rate. These features should be considered when investigating alternative treatments.
2023
Genomic Landscape Comparison of Cardiac versus Extra-Cardiac Angiosarcomas / Gozzellino, Livia; Nannini, Margherita; Urbini, Milena; Pizzi, Carmine; Leone, Ornella; Corti, Barbara; Baldovini, Chiara; Angeli, Francesco; Foà, Alberto; Pacini, Davide; Folesani, Gianluca; Costa, Alice; Palumbo, Teresa; Nigro, Maria Concetta; Pasquinelli, Gianandrea; Astolfi, Annalisa; Pantaleo, Maria Abbondanza. - In: BIOMEDICINES. - ISSN 2227-9059. - ELETTRONICO. - 11:12(2023), pp. 3290.1-3290.14. [10.3390/biomedicines11123290]
Gozzellino, Livia; Nannini, Margherita; Urbini, Milena; Pizzi, Carmine; Leone, Ornella; Corti, Barbara; Baldovini, Chiara; Angeli, Francesco; Foà, Alberto; Pacini, Davide; Folesani, Gianluca; Costa, Alice; Palumbo, Teresa; Nigro, Maria Concetta; Pasquinelli, Gianandrea; Astolfi, Annalisa; Pantaleo, Maria Abbondanza
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11585/955062
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