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EnglishChemiluminescence, i.e. the emission of light from a chemical reaction, offers interesting opportunities for developing point-of-care biosensors. However, commercially available systems are expensive, bulky, and primarily addressed to laboratory usage. The goal of this paper is to present a novel work related to the design and experimental validation of a point-of-care device for cancer marker detection in human serum. The new system has been especially developed for cost-sensitive applications using only lowcost off-the-shelf components. The system was tested with blood serum. The output signal from spots with specific proteins uptake was two orders of magnitude higher than that from control spots: it was 14±3 mV/s from the detection spots, while it was only 260V/s and 242V/s from the control spots.
| Titolo: | Cancer marker detection in human serum with a point-of-care low-cost system |
| Autore/i: | P. Grosso; S. Carrara; C. Stagni; BENINI, LUCA |
| Autore/i Unibo: | |
| Anno: | 2010 |
| Rivista: | |
| Digital Object Identifier (DOI): | http://dx.doi.org/10.1016/j.snb.2010.04.001 |
| Abstract: | Chemiluminescence, i.e. the emission of light from a chemical reaction, offers interesting opportunities for developing point-of-care biosensors. However, commercially available systems are expensive, bulky, and primarily addressed to laboratory usage. The goal of this paper is to present a novel work related to the design and experimental validation of a point-of-care device for cancer marker detection in human serum. The new system has been especially developed for cost-sensitive applications using only lowcost off-the-shelf components. The system was tested with blood serum. The output signal from spots with specific proteins uptake was two orders of magnitude higher than that from control spots: it was 14±3 mV/s from the detection spots, while it was only 260V/s and 242V/s from the control spots. |
| Data prodotto definitivo in UGOV: | 2010-12-16 12:08:29 |
| Appare nelle tipologie: | 1.01 Articolo in rivista |
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http://hdl.handle.net/11585/94519
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