Post-weaning multisystemic wasting syndrome (PMWS) is causally associated with infection of pigs by Porcine Circovirus type 2 (PCV2). Lesions in lymphoid tissues of 52 PMWS-positive pigs sampled years 1998-2000 (epidemic) were compared with lesions from 127 PMWS-positive pigs sampled 2006-2008 (endemic). A variable degree of lymphoid depletion was a constant feature in tissues with microgranulomas formed by a scant number of centrofollicular epithelioid cells, or granulomas clustered in multiple undelimited nodules with little tendency to confluence, formed by epithelioid macrophages and a few multinucleate giant cells. Granulomatosis of lymphoid tissues is known in PMWS of pigs due to type IV hypersensitivity. Granulomatosis of lymphoid tissues was apparent in 1.07% during the 1998-2000 period and in 12.42% in the more recent period. Results suggest that frequency of lymphoid granulomatosis is influenced by the epidemiology of the disease.

Granulomatosis of lymphoid tissue in post-weaning multisystemic wasting syndrome in pigs during epidemic and endemic phases.

FUSARO, LAURA;SARLI, GIUSEPPE;MORANDI, FEDERICO;BACCI, BARBARA;OSTANELLO, FABIO;MANDRIOLI, LUCIANA;MARCATO, PAOLO STEFANO
2010

Abstract

Post-weaning multisystemic wasting syndrome (PMWS) is causally associated with infection of pigs by Porcine Circovirus type 2 (PCV2). Lesions in lymphoid tissues of 52 PMWS-positive pigs sampled years 1998-2000 (epidemic) were compared with lesions from 127 PMWS-positive pigs sampled 2006-2008 (endemic). A variable degree of lymphoid depletion was a constant feature in tissues with microgranulomas formed by a scant number of centrofollicular epithelioid cells, or granulomas clustered in multiple undelimited nodules with little tendency to confluence, formed by epithelioid macrophages and a few multinucleate giant cells. Granulomatosis of lymphoid tissues is known in PMWS of pigs due to type IV hypersensitivity. Granulomatosis of lymphoid tissues was apparent in 1.07% during the 1998-2000 period and in 12.42% in the more recent period. Results suggest that frequency of lymphoid granulomatosis is influenced by the epidemiology of the disease.
L. Fusaro; G. Sarli; F. Morandi; B. Bacci; F. Ostanello; G. Leotti; L. Mandrioli; P. S. Marcato
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11585/93800
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