Aim The objective of this study was to assess left ventricle (LV) function in patients underwent arterial switch procedure (ASO) for transposition of great arteries (TGA) in long-term follow-up. Methods We studied 59 asymptomatic patients (43 male) who have undergone single-stage ASO for TGA, aged 13.9 ± 4.8 years, with a normal LV ejection fraction, compared to healthy peers. We evaluated LV volume, function and myocardial deformation in asymptomatic patients with normal ejection fraction by using speckle-tracking echocardiography (STE). Results Global longitudinal strain (GLS) was lower in patients compared to healthy peers throughout all age groups (5–9 years: −20.03 ± 0.65% vs 21.00 ± 1.30%, p = 0.083; 10–14 years: −19.43 ± 1.75% vs −21.80 ± 1.30%, p < 0.0001; 15–19 years: −19.05 ± 1.65% vs −22.50 ± 1.30%, p < 0.0001; 20–24 years: −17.90 ± 0.85% vs −20.90 ± 1.30%, p < 0.0001; >25 years: −18.60 ± 0.42% vs 20.60 ± 1.20%, p = 0.041). At the univariate analysis GLS resulted significantly related only to the presence of restrictive patent foramen ovale at birth (p = 0.0016). At the multivariate analysis GLS was significantly related to prenatal diagnosis, restrictive patent foramen ovale and by-pass time. Conclusion Children and young adults late after ASO demonstrate normal ejection fraction, but present subclinical signs of myocardial dysfunction, such as reduction of longitudinal strain. Our findings support the usefulness of STE to detect it precociously.

Left ventricle function after arterial switch procedure for D-transposition of the great arteries: Long term evaluation by speckle-tracking analysis / Giulia Bragantini; Ylenia Bartolacelli; Anna Balducci; Cristina Ciuca; Valentina Gesuete; Daniela Palleri; Gabriele Egidy Assenza; Elisabetta Mariucci; Emanuela Angeli; Gaetano Domenico Gargiulo; Andrea Donti. - In: INTERNATIONAL JOURNAL OF CARDIOLOGY CONGENITAL HEART DISEASE. - ISSN 2666-6685. - ELETTRONICO. - 8:(2022), pp. 100374-100380. [10.1016/j.ijcchd.2022.100374]

Left ventricle function after arterial switch procedure for D-transposition of the great arteries: Long term evaluation by speckle-tracking analysis

Giulia Bragantini;Anna Balducci;Cristina Ciuca;Valentina Gesuete;Daniela Palleri;Gabriele Egidy Assenza;Elisabetta Mariucci;Emanuela Angeli;Gaetano Domenico Gargiulo;
2022

Abstract

Aim The objective of this study was to assess left ventricle (LV) function in patients underwent arterial switch procedure (ASO) for transposition of great arteries (TGA) in long-term follow-up. Methods We studied 59 asymptomatic patients (43 male) who have undergone single-stage ASO for TGA, aged 13.9 ± 4.8 years, with a normal LV ejection fraction, compared to healthy peers. We evaluated LV volume, function and myocardial deformation in asymptomatic patients with normal ejection fraction by using speckle-tracking echocardiography (STE). Results Global longitudinal strain (GLS) was lower in patients compared to healthy peers throughout all age groups (5–9 years: −20.03 ± 0.65% vs 21.00 ± 1.30%, p = 0.083; 10–14 years: −19.43 ± 1.75% vs −21.80 ± 1.30%, p < 0.0001; 15–19 years: −19.05 ± 1.65% vs −22.50 ± 1.30%, p < 0.0001; 20–24 years: −17.90 ± 0.85% vs −20.90 ± 1.30%, p < 0.0001; >25 years: −18.60 ± 0.42% vs 20.60 ± 1.20%, p = 0.041). At the univariate analysis GLS resulted significantly related only to the presence of restrictive patent foramen ovale at birth (p = 0.0016). At the multivariate analysis GLS was significantly related to prenatal diagnosis, restrictive patent foramen ovale and by-pass time. Conclusion Children and young adults late after ASO demonstrate normal ejection fraction, but present subclinical signs of myocardial dysfunction, such as reduction of longitudinal strain. Our findings support the usefulness of STE to detect it precociously.
2022
Left ventricle function after arterial switch procedure for D-transposition of the great arteries: Long term evaluation by speckle-tracking analysis / Giulia Bragantini; Ylenia Bartolacelli; Anna Balducci; Cristina Ciuca; Valentina Gesuete; Daniela Palleri; Gabriele Egidy Assenza; Elisabetta Mariucci; Emanuela Angeli; Gaetano Domenico Gargiulo; Andrea Donti. - In: INTERNATIONAL JOURNAL OF CARDIOLOGY CONGENITAL HEART DISEASE. - ISSN 2666-6685. - ELETTRONICO. - 8:(2022), pp. 100374-100380. [10.1016/j.ijcchd.2022.100374]
Giulia Bragantini; Ylenia Bartolacelli; Anna Balducci; Cristina Ciuca; Valentina Gesuete; Daniela Palleri; Gabriele Egidy Assenza; Elisabetta Mariucci; Emanuela Angeli; Gaetano Domenico Gargiulo; Andrea Donti
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11585/917920
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