Wrong dietary habits, such as the Western-style diet, are considered important risk factors for the development of Inflammatory Bowel Diseases (IBDs). Nevertheless, the role of dietary patterns in the clinical management of IBD patients has not been fully investigated yet. Fifty-four patients diagnosed with active Crohn's disease (CD) were enrolled and subjected to nutritional intake analysis through a weekly food diary. Nutritional patterns were analyzed, and nutrient intake was compared with those of 30 healthy subjects (HS). Blood levels of cholesterol, folic acid, minerals (K, Mg, Fe) and amino acids, were measured in CD patients to assess the presence of nutritional deficiencies. CD patients, with respect to HS, consumed significantly lower amounts of fiber, vitamins (A, E, C, B6, folic acid) and beta-carotene. Their calcium, potassium, phosphorus, iron, magnesium, copper and iodine intake were also found to be significantly lower. In blood, CD patients had significantly lower concentrations of total cholesterol, potassium, iron, and amino acids. Active CD patient diet was significantly different from those of HS and may contribute to the establishment of nutritional deficiencies. Intestinal malabsorption was evidenced in these patients. Correction of the diet with specific nutritional plans is a necessary therapeutic step for these patients. ClinicalTrials.gov: NCT02580864.

Rizzello, F., Gionchetti, P., Spisni, E., Saracino, I.M., Bellocchio, I., Spigarelli, R., et al. (2023). Dietary Habits and Nutrient Deficiencies in a Cohort of European Crohn's Disease Adult Patients. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 24(2), 1-14 [10.3390/ijms24021494].

Dietary Habits and Nutrient Deficiencies in a Cohort of European Crohn's Disease Adult Patients

Rizzello, Fernando;Gionchetti, Paolo;Spisni, Enzo
;
Saracino, Ilaria Maria;Bellocchio, Irene;Spigarelli, Renato;Alvisi, Patrizia;Valerii, Maria Chiara
2023

Abstract

Wrong dietary habits, such as the Western-style diet, are considered important risk factors for the development of Inflammatory Bowel Diseases (IBDs). Nevertheless, the role of dietary patterns in the clinical management of IBD patients has not been fully investigated yet. Fifty-four patients diagnosed with active Crohn's disease (CD) were enrolled and subjected to nutritional intake analysis through a weekly food diary. Nutritional patterns were analyzed, and nutrient intake was compared with those of 30 healthy subjects (HS). Blood levels of cholesterol, folic acid, minerals (K, Mg, Fe) and amino acids, were measured in CD patients to assess the presence of nutritional deficiencies. CD patients, with respect to HS, consumed significantly lower amounts of fiber, vitamins (A, E, C, B6, folic acid) and beta-carotene. Their calcium, potassium, phosphorus, iron, magnesium, copper and iodine intake were also found to be significantly lower. In blood, CD patients had significantly lower concentrations of total cholesterol, potassium, iron, and amino acids. Active CD patient diet was significantly different from those of HS and may contribute to the establishment of nutritional deficiencies. Intestinal malabsorption was evidenced in these patients. Correction of the diet with specific nutritional plans is a necessary therapeutic step for these patients. ClinicalTrials.gov: NCT02580864.
2023
Rizzello, F., Gionchetti, P., Spisni, E., Saracino, I.M., Bellocchio, I., Spigarelli, R., et al. (2023). Dietary Habits and Nutrient Deficiencies in a Cohort of European Crohn's Disease Adult Patients. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 24(2), 1-14 [10.3390/ijms24021494].
Rizzello, Fernando; Gionchetti, Paolo; Spisni, Enzo; Saracino, Ilaria Maria; Bellocchio, Irene; Spigarelli, Renato; Collini, Noemi; Imbesi, Veronica; Dervieux, Thierry; Alvisi, Patrizia; Valerii, Maria Chiara
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11585/917288
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