Polyvinyl alcohol was substituted with succinic anhydride and glutaric anhydride to obtain polymers with pH-dependent solubility. The polymers were assessed as potential substrate materials for pH-dependent drug delivery systems. Ibuprofen was used as a model drug, where pH-dependent release could avoid its gastric side effects. Coprecipitates of the drug and the polymer at 1/1, 2/1 and 3/1 w/w ratios were prepared and release of the drug from the coprecipitates was evaluated in vitro at pH 2.0, 5.5, 7.0, 8.0. The results indicated the ability of the substituted polymers to hinder drug release in acidic aqueous environments while allowing release at higher pH values.
Orienti, I., Speroni, E., Bigucci, F., Zecchi, V. (2000). Polyvinyl alcohol succinate and glutarate coprecipitated with ibuprofen as pH-sensitive drug delivery systems. STP PHARMA SCIENCES, 10(5), 405-408.
Polyvinyl alcohol succinate and glutarate coprecipitated with ibuprofen as pH-sensitive drug delivery systems
Orienti I.
;Speroni E.;Bigucci F.;Zecchi V.
2000
Abstract
Polyvinyl alcohol was substituted with succinic anhydride and glutaric anhydride to obtain polymers with pH-dependent solubility. The polymers were assessed as potential substrate materials for pH-dependent drug delivery systems. Ibuprofen was used as a model drug, where pH-dependent release could avoid its gastric side effects. Coprecipitates of the drug and the polymer at 1/1, 2/1 and 3/1 w/w ratios were prepared and release of the drug from the coprecipitates was evaluated in vitro at pH 2.0, 5.5, 7.0, 8.0. The results indicated the ability of the substituted polymers to hinder drug release in acidic aqueous environments while allowing release at higher pH values.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
