Nanorod Photocatalysts for C-O Cross-Coupling Reactions

Carbon-heteroatom cross-coupling reactions are significant for numerous industrial chemical processes, in particular for the synthesis of pharmaceuticals, agrochemicals, and biologically active compounds. Photocatalyst/transition metal dual catalytic systems pave a new avenue for organic cross-coupling reactions. Specifically, the use of semiconductor nanoparticles as heterogeneous light sensitizers is highly beneficial for industrial-scale applications owing to their low-cost production, tunable photophysical properties, facile separation, high photostability, and recyclability. Here, CdSe@CdS nanorod photocatalysts are combined with a Ni complex catalyst for the promotion of selective light-induced C-O cross-coupling reactions between aryl halides and alkyl carboxylic acids. This efficient dual photocatalytic system displays a high yield (similar to 96 %), with an impressive turnover number (TON) of over 3x10(6), and within a relatively short reaction time as a result of high turnover frequency (TOF) of similar to 56 s(-1). In addition, the nanorod photocatalysts harness light with improved solar to product efficiency compared to alternative systems, signaling towards potential solar-powered chemistry. A reaction mechanism involving energy transfer from the nanorods to the Ni complex is proposed and discussed, along with specific benefits of the seeded rod morphology.