The concept that polyamines may represent a passe-partout (Master key) for G-protein-coupled receptors recognition is illustrated. Using a linear tetraamine as the focus, appropriate structural modifications have allowed to obtain novel tetraamines displaying selectivity for different receptor systems. It is shown that tetraamines have receptor subtype selectivity since they are site-directed, owing to different chain lengths separating the protonable nitrogens and to the presence of those peculiar structural elements which make them able of discriminating at the binding stage. © 1996 Elsevier B.V. All rights reserved.
Melchiorre C., Angeli P., Bolognesi M.L., Budriesi R., Cacciaguerra S., Chiarini A., et al. (1996). Tetraamines as lead compounds for the design of neurotransmitter receptor ligands:Focus on α-adrenergic and muscarinic receptors recognition, 24(C), 321-336 [10.1016/S0165-7208(96)80026-2].
Tetraamines as lead compounds for the design of neurotransmitter receptor ligands:Focus on α-adrenergic and muscarinic receptors recognition
Melchiorre C.;Bolognesi M. L.;Budriesi R.;Chiarini A.;Marucci G.;Minarini A.;Spampinato S.;Tumiatti V.
1996
Abstract
The concept that polyamines may represent a passe-partout (Master key) for G-protein-coupled receptors recognition is illustrated. Using a linear tetraamine as the focus, appropriate structural modifications have allowed to obtain novel tetraamines displaying selectivity for different receptor systems. It is shown that tetraamines have receptor subtype selectivity since they are site-directed, owing to different chain lengths separating the protonable nitrogens and to the presence of those peculiar structural elements which make them able of discriminating at the binding stage. © 1996 Elsevier B.V. All rights reserved.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
