A series of 1,4-dihydropyridines bearing a coumarin moiety in 4-position was synthesized. The compounds were evaluated for inotropic, chronotropic and calcium antagonist activities. The replacement of the o-nitrophenyl moiety of nifedipine with a coumarin or phenylcoumarin system is accompained by a decrease of the activity on myocardial and vascular parameters, but the synthesized compounds showed selective inhibiting effects on cardiac contractility and frequency. Copyright (C) 1998 Elsevier Science Ltd.
Valenti P., Rampa A., Budriesi R., Bisi A., Chiarini A. (1998). Coumarin 1,4-dihydropyridine derivatives. BIOORGANIC & MEDICINAL CHEMISTRY, 6(6), 803-810 [10.1016/S0968-0896(98)00037-6].
Coumarin 1,4-dihydropyridine derivatives
Valenti P.;Rampa A.;Budriesi R.;Bisi A.;Chiarini A.
1998
Abstract
A series of 1,4-dihydropyridines bearing a coumarin moiety in 4-position was synthesized. The compounds were evaluated for inotropic, chronotropic and calcium antagonist activities. The replacement of the o-nitrophenyl moiety of nifedipine with a coumarin or phenylcoumarin system is accompained by a decrease of the activity on myocardial and vascular parameters, but the synthesized compounds showed selective inhibiting effects on cardiac contractility and frequency. Copyright (C) 1998 Elsevier Science Ltd.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
