A series of xanthone and fluorenone-1,4-dihydropyridine derivatives bearing a 5-phosphonate group were prepared. The compounds were evaluated for inotropic, chronotropic and calcium antagonistic properties. The insertion of a phosphonate group is detrimental for inotropic and calcium antagonistic aciivity but improves the potency and selectivity for chronotropism.
Budriesi R., Rampa A., Bisi A., Fabbri G., Chiarini A., Valenti P. (1996). Structure-activity relationship studies of xanthone and fluorenone-1,4-dihydropyridine-5-phosphonates. ARZNEIMITTEL-FORSCHUNG, 46(4), 374-377.
Structure-activity relationship studies of xanthone and fluorenone-1,4-dihydropyridine-5-phosphonates
Budriesi R.;Rampa A.;Bisi A.;Fabbri G.;Chiarini A.;Valenti P.
1996
Abstract
A series of xanthone and fluorenone-1,4-dihydropyridine derivatives bearing a 5-phosphonate group were prepared. The compounds were evaluated for inotropic, chronotropic and calcium antagonistic properties. The insertion of a phosphonate group is detrimental for inotropic and calcium antagonistic aciivity but improves the potency and selectivity for chronotropism.File in questo prodotto:
Eventuali allegati, non sono esposti
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
