A series of xanthone and fluorenone-1,4-dihydropyridine derivatives bearing a 5-phosphonate group were prepared. The compounds were evaluated for inotropic, chronotropic and calcium antagonistic properties. The insertion of a phosphonate group is detrimental for inotropic and calcium antagonistic aciivity but improves the potency and selectivity for chronotropism.
Structure-activity relationship studies of xanthone and fluorenone-1,4-dihydropyridine-5-phosphonates / Budriesi R.; Rampa A.; Bisi A.; Fabbri G.; Chiarini A.; Valenti P.. - In: ARZNEIMITTEL-FORSCHUNG. - ISSN 0004-4172. - STAMPA. - 46:4(1996), pp. 374-377.
Structure-activity relationship studies of xanthone and fluorenone-1,4-dihydropyridine-5-phosphonates
Budriesi R.;Rampa A.;Bisi A.;Fabbri G.;Chiarini A.;Valenti P.
1996
Abstract
A series of xanthone and fluorenone-1,4-dihydropyridine derivatives bearing a 5-phosphonate group were prepared. The compounds were evaluated for inotropic, chronotropic and calcium antagonistic properties. The insertion of a phosphonate group is detrimental for inotropic and calcium antagonistic aciivity but improves the potency and selectivity for chronotropism.File in questo prodotto:
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