A series of xanthone-1,4-dihydropyridine derivatives bearing a chlorine atom in the xanthone nucleus was prepared. The compounds were evaluated for inotropic, chronotropic and calcium antagonist properties. The chlorine introduction in the xanthone moiety slightly affected affinity for cardiac vs. vascular tissues improving to some extent selectivity.
Synthesis and pharmacological profile of some chloroxanthone-1,4-dihydropyridine derivatives / Bisi A.; Budriesi R.; Rampa A.; Fabbri G.; Chiarini A.; Valenti P.. - In: ARZNEIMITTEL-FORSCHUNG. - ISSN 0004-4172. - STAMPA. - 46:9(1996), pp. 848-851.
Synthesis and pharmacological profile of some chloroxanthone-1,4-dihydropyridine derivatives
Bisi A.;Budriesi R.;Rampa A.;Fabbri G.;Chiarini A.;Valenti P.
1996
Abstract
A series of xanthone-1,4-dihydropyridine derivatives bearing a chlorine atom in the xanthone nucleus was prepared. The compounds were evaluated for inotropic, chronotropic and calcium antagonist properties. The chlorine introduction in the xanthone moiety slightly affected affinity for cardiac vs. vascular tissues improving to some extent selectivity.File in questo prodotto:
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