Two constrained analogues (4a and 4b) of both 4-DAMP (1) and spiro-DAMP (2) were designed, and their biological profiles at muscarinic receptor subtypes were assessed by functional and binding assays. It turned out that these constrained analogues display a modest, if any, M2/M3 selectivity ratio. However, most interestingly, they proved to be highly selective for muscarinic M1 receptors. © 1995.

Design, synthesis and biological activity of some 4-DAMP- related compounds / Tumiatti V.; Santi S.; Recanatini M.; Minarini A.; Melchiorre C.; Chiarini A.; Budriesi R.. - In: BIOORGANIC & MEDICINAL CHEMISTRY LETTERS. - ISSN 0960-894X. - STAMPA. - 5:20(1995), pp. 2325-2330. [10.1016/0960-894X(95)00403-G]

Design, synthesis and biological activity of some 4-DAMP- related compounds

Tumiatti V.;Santi S.;Recanatini M.;Minarini A.;Melchiorre C.;Chiarini A.;Budriesi R.
1995

Abstract

Two constrained analogues (4a and 4b) of both 4-DAMP (1) and spiro-DAMP (2) were designed, and their biological profiles at muscarinic receptor subtypes were assessed by functional and binding assays. It turned out that these constrained analogues display a modest, if any, M2/M3 selectivity ratio. However, most interestingly, they proved to be highly selective for muscarinic M1 receptors. © 1995.
1995
Design, synthesis and biological activity of some 4-DAMP- related compounds / Tumiatti V.; Santi S.; Recanatini M.; Minarini A.; Melchiorre C.; Chiarini A.; Budriesi R.. - In: BIOORGANIC & MEDICINAL CHEMISTRY LETTERS. - ISSN 0960-894X. - STAMPA. - 5:20(1995), pp. 2325-2330. [10.1016/0960-894X(95)00403-G]
Tumiatti V.; Santi S.; Recanatini M.; Minarini A.; Melchiorre C.; Chiarini A.; Budriesi R.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11585/911651
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