Two constrained analogues (4a and 4b) of both 4-DAMP (1) and spiro-DAMP (2) were designed, and their biological profiles at muscarinic receptor subtypes were assessed by functional and binding assays. It turned out that these constrained analogues display a modest, if any, M2/M3 selectivity ratio. However, most interestingly, they proved to be highly selective for muscarinic M1 receptors. © 1995.
Design, synthesis and biological activity of some 4-DAMP- related compounds
Tumiatti V.;Santi S.;Recanatini M.;Minarini A.;Melchiorre C.;Chiarini A.;Budriesi R.
1995
Abstract
Two constrained analogues (4a and 4b) of both 4-DAMP (1) and spiro-DAMP (2) were designed, and their biological profiles at muscarinic receptor subtypes were assessed by functional and binding assays. It turned out that these constrained analogues display a modest, if any, M2/M3 selectivity ratio. However, most interestingly, they proved to be highly selective for muscarinic M1 receptors. © 1995.File in questo prodotto:
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