A series of some benzazepinone derivatives were prepared. The compounds were evaluated for inotropic, chronotropic and calcium antagonist properties. For the compounds bearing well-known alpha-blocking fragments, the antagonist potency at postsynaptic alpha-adrenoceptors was assessed. The new compounds were less effective as bradycardic agents and calcium antagonists but show remarkable negative inotropic activity.
Budriesi R., Rampa A., Bisi A., Fabbri G., Chiarini A., Valenti P. (1995). Synthesis and pharmacological characterization of some benzazepinone derivatives. ARZNEIMITTEL-FORSCHUNG, 45(3), 234-239.
Synthesis and pharmacological characterization of some benzazepinone derivatives
Budriesi R.;Rampa A.;Bisi A.;Fabbri G.;Chiarini A.;Valenti P.
1995
Abstract
A series of some benzazepinone derivatives were prepared. The compounds were evaluated for inotropic, chronotropic and calcium antagonist properties. For the compounds bearing well-known alpha-blocking fragments, the antagonist potency at postsynaptic alpha-adrenoceptors was assessed. The new compounds were less effective as bradycardic agents and calcium antagonists but show remarkable negative inotropic activity.File in questo prodotto:
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