PERFIDI (Parametrically Enabled Relaxation FIlters with Double and multiple Inversion) is an experimental NMR/MRI technique devised to analyze samples/voxels characterized by multi-exponential longitudinal relaxation. It is based on a linear combination of NMR sequences with suitable preambles composed of inversion pulses. Given any standard NMR/MRI sequence, it permits one to modify it in a way which will attenuate, in a predictable manner and before data acquisition, signals arising from components with different r rates (r = 1/T1). Consequently, it is possible to define relatively simple protocols to suppress and/or to quantify signals of different components. This article describes a simple way to construct low-pass, high-pass and band-pass PERFIDI filters. Experimental data are presented in which the method has been used to separate fat and water proton signals. We also present a novel protocol for very fast determination of the ratio between the fat signal and the total signal which avoids any time-consuming magnetization recovery multi-array data acquisition. The method has been validated also for MRI, producing well T1-contrasted images.

V. Bortolotti, P. Fantazzini, M. Gombia, D. Greco, G. Rinaldin, S. Sykora (2010). PERFIDI filters to suppress and/or quantify relaxation time components in multicomponent systems: an example for fat-water systems. JOURNAL OF MAGNETIC RESONANCE, 206, 219-226 [10.1016/j.jmr.2010.07.010].

PERFIDI filters to suppress and/or quantify relaxation time components in multicomponent systems: an example for fat-water systems

BORTOLOTTI, VILLIAM;FANTAZZINI, PAOLA;GOMBIA, MIRKO;
2010

Abstract

PERFIDI (Parametrically Enabled Relaxation FIlters with Double and multiple Inversion) is an experimental NMR/MRI technique devised to analyze samples/voxels characterized by multi-exponential longitudinal relaxation. It is based on a linear combination of NMR sequences with suitable preambles composed of inversion pulses. Given any standard NMR/MRI sequence, it permits one to modify it in a way which will attenuate, in a predictable manner and before data acquisition, signals arising from components with different r rates (r = 1/T1). Consequently, it is possible to define relatively simple protocols to suppress and/or to quantify signals of different components. This article describes a simple way to construct low-pass, high-pass and band-pass PERFIDI filters. Experimental data are presented in which the method has been used to separate fat and water proton signals. We also present a novel protocol for very fast determination of the ratio between the fat signal and the total signal which avoids any time-consuming magnetization recovery multi-array data acquisition. The method has been validated also for MRI, producing well T1-contrasted images.
2010
V. Bortolotti, P. Fantazzini, M. Gombia, D. Greco, G. Rinaldin, S. Sykora (2010). PERFIDI filters to suppress and/or quantify relaxation time components in multicomponent systems: an example for fat-water systems. JOURNAL OF MAGNETIC RESONANCE, 206, 219-226 [10.1016/j.jmr.2010.07.010].
V. Bortolotti; P. Fantazzini; M. Gombia; D. Greco; G. Rinaldin; S. Sykora
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11585/90717
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