Tendons and ligaments (T/L) are connective tissues with complex multiscale structure and mechanical properties [1]. Electrospinning can replicate T/L from the fibrillar-level up to the whole tissue [2]. Nylon6,6 (NY) and polyurethane (PU) are suitable polymers for T/L tissue replacement [3, 4]. In this study, we produced electrospun NY fascicle-inspired bundles, grouping them with electrospun membranes of NY or PU (reproducing the ones covering the natural tissue) in different T/L levels of hierarchical complexity. The study aimed to identify the relationship between the structure and mechanics of these devices when the hierarchical complexity was increased and the materials of membranes were changed.
Alberto Sensini, C.G. (2022). Multiscale Performances of Hierarchical Electrospun Biostable Devices for Tendon and Ligament Replacement. London.
Multiscale Performances of Hierarchical Electrospun Biostable Devices for Tendon and Ligament Replacement
Carlo Gotti;Chiara Gualandi;Nicola Sancisi;Maria Letizia Focarete;Luca Cristofolini;Andrea Zucchelli
2022
Abstract
Tendons and ligaments (T/L) are connective tissues with complex multiscale structure and mechanical properties [1]. Electrospinning can replicate T/L from the fibrillar-level up to the whole tissue [2]. Nylon6,6 (NY) and polyurethane (PU) are suitable polymers for T/L tissue replacement [3, 4]. In this study, we produced electrospun NY fascicle-inspired bundles, grouping them with electrospun membranes of NY or PU (reproducing the ones covering the natural tissue) in different T/L levels of hierarchical complexity. The study aimed to identify the relationship between the structure and mechanics of these devices when the hierarchical complexity was increased and the materials of membranes were changed.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
