Tendons and ligaments (T/L) are connective tissues with a complex multiscale structure and mechanical properties [1]. Electrospinning can replicate T/L from the fibrillar-level up to the whole tissue [2]. Electrospun nylon6,6 (NY) and polyurethane (PU) are suitable polymers for the musculoskeletal tissue replacement [3, 4]. In this study, we produced electrospun NY fascicleinspired bundles, grouping them with electrospun membranes of NY or PU (simulating the collagen sheath covering the natural tissues) in different T/L levels of hierarchical complexity. The aim of the study was to identify the relationship between the structure and mechanics of these devices when their hierarchical complexity was increased, and the materials of membranes was changed.
Alberto Sensini, C.G. (2022). MULTISCALE PERFORMANCES OF ELECTROSPUN BIOSTABLE DEVICES FOR TENDON AND LIGAMENT REPLACEMENT. Porto.
MULTISCALE PERFORMANCES OF ELECTROSPUN BIOSTABLE DEVICES FOR TENDON AND LIGAMENT REPLACEMENT
Carlo Gotti;Chiara Gualandi;Nicola Sancisi;Maria Letizia Focarete;Luca Cristofolini;Andrea Zucchelli
2022
Abstract
Tendons and ligaments (T/L) are connective tissues with a complex multiscale structure and mechanical properties [1]. Electrospinning can replicate T/L from the fibrillar-level up to the whole tissue [2]. Electrospun nylon6,6 (NY) and polyurethane (PU) are suitable polymers for the musculoskeletal tissue replacement [3, 4]. In this study, we produced electrospun NY fascicleinspired bundles, grouping them with electrospun membranes of NY or PU (simulating the collagen sheath covering the natural tissues) in different T/L levels of hierarchical complexity. The aim of the study was to identify the relationship between the structure and mechanics of these devices when their hierarchical complexity was increased, and the materials of membranes was changed.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
