Compounds currently used for the treatment of HIV-1 infections are targeted to viral proteins. However, the high intrinsic mutation and replication rates of HIV-1 led to the emergence of drug resistant strains with a consequent therapeutic failure. On this basis, cellular cofactors represent attractive new targets for HIV-1 chemotherapy, since targeting a cellular factor that is required for viral replication should help to overcome the problem of viral resistance. We aimed to develop through rational design a series of non-nucleosidic inhibitors of the HIV-1 cellular cofactor DDX3 and show that they can be used to block viral proliferation.
Giovanni Maga, F.F. (2010). Inhibitors of human immunodeficiency virus-1 replication targeting the human DEAD-box polypeptide 3 (DDX3) RNA helicase. RETROVIROLOGY, 7, 1-1 [10.1186/1742-4690-7-S1-O16].
Inhibitors of human immunodeficiency virus-1 replication targeting the human DEAD-box polypeptide 3 (DDX3) RNA helicase
Federico Falchi;
2010
Abstract
Compounds currently used for the treatment of HIV-1 infections are targeted to viral proteins. However, the high intrinsic mutation and replication rates of HIV-1 led to the emergence of drug resistant strains with a consequent therapeutic failure. On this basis, cellular cofactors represent attractive new targets for HIV-1 chemotherapy, since targeting a cellular factor that is required for viral replication should help to overcome the problem of viral resistance. We aimed to develop through rational design a series of non-nucleosidic inhibitors of the HIV-1 cellular cofactor DDX3 and show that they can be used to block viral proliferation.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
