Objectives: To describe a case of equine muscular dystrophy with myotonia. Methods: A 5-year-old horse presented with hypertrophy and delayed relaxation of the muscles of the hindlimbs from age 2 months. Testicular atrophy developed from 2 years of age. Action and percussion myotonia was associated with weakness in these muscles, and EMG showed diffuse myotonic discharges and myopathic features. Biopsy of the gluteal muscle showed adipose and connective tissue infiltration, marked variation in muscle fibre size, and moth-eaten, ring and whorled fibres. Results: Injection of apamin, a peptide blocker of calcium-activated potassium channels, which inhibits myotonia in human myotonic dystrophy, was ineffective in blocking myotonic discharges. Discharges promptly abated with 2% lidocaine injection. Conclusions: Myotonia in this horse is associated with dystrophic changes similar to human myotonic dystrophy, though there are some pharmacological differences. © 2001 Elsevier Science Ireland Ltd.

Montagna P., Liguori R., Monari L., Strong P.N, Riva R., Di Stasi V., et al. (2001). Equine muscular dystrophy with myotonia. CLINICAL NEUROPHYSIOLOGY, 112(2), 294-299 [10.1016/S1388-2457(00)00511-3].

Equine muscular dystrophy with myotonia

Montagna P.;Liguori R.;Di Stasi V.;Gandini G.;Cipone M.
2001

Abstract

Objectives: To describe a case of equine muscular dystrophy with myotonia. Methods: A 5-year-old horse presented with hypertrophy and delayed relaxation of the muscles of the hindlimbs from age 2 months. Testicular atrophy developed from 2 years of age. Action and percussion myotonia was associated with weakness in these muscles, and EMG showed diffuse myotonic discharges and myopathic features. Biopsy of the gluteal muscle showed adipose and connective tissue infiltration, marked variation in muscle fibre size, and moth-eaten, ring and whorled fibres. Results: Injection of apamin, a peptide blocker of calcium-activated potassium channels, which inhibits myotonia in human myotonic dystrophy, was ineffective in blocking myotonic discharges. Discharges promptly abated with 2% lidocaine injection. Conclusions: Myotonia in this horse is associated with dystrophic changes similar to human myotonic dystrophy, though there are some pharmacological differences. © 2001 Elsevier Science Ireland Ltd.
2001
Montagna P., Liguori R., Monari L., Strong P.N, Riva R., Di Stasi V., et al. (2001). Equine muscular dystrophy with myotonia. CLINICAL NEUROPHYSIOLOGY, 112(2), 294-299 [10.1016/S1388-2457(00)00511-3].
Montagna P.; Liguori R.; Monari L.; Strong P.N; Riva R.; Di Stasi V.; Gandini G.; Cipone M.
File in questo prodotto:
Eventuali allegati, non sono esposti

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11585/902784
 Attenzione

Attenzione! I dati visualizzati non sono stati sottoposti a validazione da parte dell'ateneo

Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus 30
  • ???jsp.display-item.citation.isi??? 21
social impact