Our aim was to elaborate a method to optimise treatment intervals for the individual low-density lipoprotein (LDL)-apheresis treated patients. After each treatment, plasma LDL concentrations show a time-related increase with a decreasing speed until a maximum level.We searched to interpret the post- LDL-apheresis experimental data trend as the physical process that produces the observed curve, so that the fitting presupposed theoretical function is a direct consequence of the physic process, because to establish the better time. Applying the proposed fitting method to a succession of 15 samples obtained from the mean of six plasmapheresis executed on five different subjects, small estimate standard error (5 mg/dl) and relative error (1.7%) with a dispersion evidently related to the experimental error were observed. Obviously, applying the same method to a single case, the dispersion is more marked (relative error ,5%), with a SE of 10–13 mg/dl, even though the aspect of a casual phenomenon is conserved. Our physical interpretation appears to be a practical model to predict the LDL-rebound kinetic of the single patient.

Application of a new processing method to post-LDL-apheresis data / Corsini F, Cicero AF, Giannuzzi A, Gaddi A.. - In: JOURNAL OF THEORETICAL MEDICINE. - ISSN 1027-3662. - STAMPA. - 4:3(2002), pp. 191-196. [10.1080/1027366021000041403]

Application of a new processing method to post-LDL-apheresis data.

Cicero AF
Writing – Original Draft Preparation
;
Gaddi A.
2002

Abstract

Our aim was to elaborate a method to optimise treatment intervals for the individual low-density lipoprotein (LDL)-apheresis treated patients. After each treatment, plasma LDL concentrations show a time-related increase with a decreasing speed until a maximum level.We searched to interpret the post- LDL-apheresis experimental data trend as the physical process that produces the observed curve, so that the fitting presupposed theoretical function is a direct consequence of the physic process, because to establish the better time. Applying the proposed fitting method to a succession of 15 samples obtained from the mean of six plasmapheresis executed on five different subjects, small estimate standard error (5 mg/dl) and relative error (1.7%) with a dispersion evidently related to the experimental error were observed. Obviously, applying the same method to a single case, the dispersion is more marked (relative error ,5%), with a SE of 10–13 mg/dl, even though the aspect of a casual phenomenon is conserved. Our physical interpretation appears to be a practical model to predict the LDL-rebound kinetic of the single patient.
2002
Application of a new processing method to post-LDL-apheresis data / Corsini F, Cicero AF, Giannuzzi A, Gaddi A.. - In: JOURNAL OF THEORETICAL MEDICINE. - ISSN 1027-3662. - STAMPA. - 4:3(2002), pp. 191-196. [10.1080/1027366021000041403]
Corsini F, Cicero AF, Giannuzzi A, Gaddi A.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11585/902345
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