Gait performance in toddlers born preterm: A sensor based quantitative characterization

Background and Objectives: Preterm children have an increased risk of motor difficulties. Gait analysis and wearable technologies allow the assessment of motor performance in toddlers, identifying early deviations from typical development. Using a sensor-based approach, gait performance of full-term and preterm toddlers at different risk of motor delay was analysed. The aim was to measure quantitative differences among groups. Methods: Twenty-nine two-year old children born preterm ( <36 gestational weeks) and 17 full-term controls, matched for age and walking experience, participated in the study. Preterm children were further divided based on risk of motor delay: preterm at high risk ( n = 8, born at <28 gestational weeks or with <10 0 0 g of body weight), and at moderate risk ( n = 21). Children were asked to walk along a corridor while wearing 3 inertial sensors on the lower back and on the ankles. Gait temporal parameters, their variability, and nonlinear metrics of trunk kinematics (i.e. recurrence quantification analysis, multiscale entropy) were extracted from the collected data and compared among groups. Results: Children born preterm showed significantly longer stance and double support phases, higher variability of temporal parameters, and lower multiscale entropy values than peers born full-term. No difference was found for the other parameters when comparing preterm and full-term children. When comparing children grouped according to risk of delay, with increasing risk, children showed longer stride-, stance- and double-support-time, higher variability of temporal parameters, higher recurrence- and lower multiscale entropy values. Conclusions: Sensor-based gait analysis allowed differentiating the gait performance of preterm from fullterm toddlers, and of preterm toddlers at different risk of motor delay. When analysing the present results with respect to the expected trajectory of locomotor development, children born preterm, in particular those at higher risk of motor delay, exhibited a less mature motor control performance during gait: lower stability (i.e. longer support phases), and higher variability, although not structured towards the exploration of more complex movements (i.e. higher recurrence- and lower multiscale entropy values). These indexes can serve as biomarkers for monitoring locomotor development and early detecting risk to develop persistent motor impairments.