In this work, three genetic regulatory networks are considered, that model the post–transcriptional regulation of the PTEN onco suppressor gene, mediated by microRNAs and competitive endogenous RNAs, in glioblastoma multiforme, the most severe of brain tumours. We simulate solutions of the resulting stochastic differential systems and discuss the effects of this miRNA-fashioned regulation on PTEN expression.
Stochastic modelling and simulation of PTEN regulatory networks with miRNAs and ceRNAs / Carletti Margherita; Spaletta Giulia. - In: ANNALI DELL'UNIVERSITÀ DI FERRARA. SCIENZE MATEMATICHE. - ISSN 1827-1510. - ELETTRONICO. - 68:2(2022), pp. 0416.645-0416.659. [10.1007/s11565-022-00416-7]
Stochastic modelling and simulation of PTEN regulatory networks with miRNAs and ceRNAs
Spaletta Giulia
Secondo
2022
Abstract
In this work, three genetic regulatory networks are considered, that model the post–transcriptional regulation of the PTEN onco suppressor gene, mediated by microRNAs and competitive endogenous RNAs, in glioblastoma multiforme, the most severe of brain tumours. We simulate solutions of the resulting stochastic differential systems and discuss the effects of this miRNA-fashioned regulation on PTEN expression.| File | Dimensione | Formato | |
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