A patient had recurrent spontaneous episodes of stupor or coma in the absence of toxic, metabolic, or structural brain damage. Ictal electroencephalography showed fast 14 Hz background activity; sleep studies excluded narcolepsy. Flumazenil (Anexate), a benzodiazepine antagonist, promptly resolved the episodes and normalized the electroencephalogram. Radioreceptor binding studies showed the presence of a ligand to the central benzodiazepine receptor in plasma and cerebrospinal fluid during the episodes, suggesting a gamma‐aminobutyric acid (GABA)ergic system involvement in the origin of the attacks.
Tinuper P., Montagna P., Cortelli P., Avoni P., Lugaresi A., Schoch P., et al. (1992). Idiopathic recurring stupor: A case with possible involvement of the gamma–aminobutyric acid (GABA)ergic system. ANNALS OF NEUROLOGY, 31(5), 503-506 [10.1002/ana.410310507].
Idiopathic recurring stupor: A case with possible involvement of the gamma–aminobutyric acid (GABA)ergic system
Tinuper P.;Montagna P.;Cortelli P.;Avoni P.;Lugaresi A.Investigation
;Gallassi R.;Lugaresi E.
1992
Abstract
A patient had recurrent spontaneous episodes of stupor or coma in the absence of toxic, metabolic, or structural brain damage. Ictal electroencephalography showed fast 14 Hz background activity; sleep studies excluded narcolepsy. Flumazenil (Anexate), a benzodiazepine antagonist, promptly resolved the episodes and normalized the electroencephalogram. Radioreceptor binding studies showed the presence of a ligand to the central benzodiazepine receptor in plasma and cerebrospinal fluid during the episodes, suggesting a gamma‐aminobutyric acid (GABA)ergic system involvement in the origin of the attacks.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
