Five SARS-CoV-2-positive samples showed N-gene drop-out with a RT-PCR multiplex test. WGS found all samples to harbor a deletion in the same region of the N gene, which is likely to impair the efficiency of amplification. This highlights the need for a continued surveillance of viral evolution and diagnostic test performance.
Zannoli S., Dirani G., Taddei F., Gatti G., Poggianti I., Denicolo A., et al. (2022). A deletion in the N gene may cause diagnostic escape in SARS-CoV-2 samples. DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE, 102(1), 115540-115542 [10.1016/j.diagmicrobio.2021.115540].
A deletion in the N gene may cause diagnostic escape in SARS-CoV-2 samples
Zannoli S.;Dirani G.;Gatti G.;Arfilli V.;Battisti A.;Sambri V.
2022
Abstract
Five SARS-CoV-2-positive samples showed N-gene drop-out with a RT-PCR multiplex test. WGS found all samples to harbor a deletion in the same region of the N gene, which is likely to impair the efficiency of amplification. This highlights the need for a continued surveillance of viral evolution and diagnostic test performance.File in questo prodotto:
Eventuali allegati, non sono esposti
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
