In recent years, an autoantibody directed against the 5′-citosolic nucleotidase1A (cN1A) was identified in the sera of sporadic inclusion body myositis (s-IBM) patients with widely variable sensitivity (33%–76%) and specificity (87%–100%). We assessed the sensitivity/specificity of anti-cN1A antibodies in an Italian cohort of s-IBM patients, searching for a potential correlation with clinical data. We collected clinical data and sera from 62 consecutive s-IBM patients and 62 other inflammatory myopathies patients. Testing for anti-cN1A antibodies was performed using a com-mercial ELISA. Anti-cN1A antibodies were detected in 23 s-IBM patients, resulting in a sensitivity of 37.1% with a specificity of 96.8%. Positive and negative predictive values were 92.0% and 60.6%, respectively. We did not find significant difference regarding demographic variables, nor quadriceps or finger flexor weakness. Nevertheless, we found that anti-cN1A-positive patients presented significantly lower scores in IBMFRS item 1 (swallowing, p = 0.045) and more frequently reported more severe swallowing problems, expressed as an IBMFRS item 1 score ≤ 2 (p < 0.001). We confirmed the low sensitivity and high specificity of anti-cN1A Ab in s-IBM patients with a high positive predictive value. The presence of anti-CN1A antibodies identified patients with a greater risk of more severe dysphagia.

Anti-cN1A antibodies are associated with more severe dysphagia in sporadic inclusion body myositis / Lucchini M.; Maggi L.; Pegoraro E.; Filosto M.; Rodolico C.; Antonini G.; Garibaldi M.; Valentino M.L.; Siciliano G.; Tasca G.; De Arcangelis V.; De Fino C.; Mirabella M.. - In: CELLS. - ISSN 2073-4409. - ELETTRONICO. - 10:5(2021), pp. 1146.1146-1146.1146. [10.3390/cells10051146]

Anti-cN1A antibodies are associated with more severe dysphagia in sporadic inclusion body myositis

Valentino M. L.;
2021

Abstract

In recent years, an autoantibody directed against the 5′-citosolic nucleotidase1A (cN1A) was identified in the sera of sporadic inclusion body myositis (s-IBM) patients with widely variable sensitivity (33%–76%) and specificity (87%–100%). We assessed the sensitivity/specificity of anti-cN1A antibodies in an Italian cohort of s-IBM patients, searching for a potential correlation with clinical data. We collected clinical data and sera from 62 consecutive s-IBM patients and 62 other inflammatory myopathies patients. Testing for anti-cN1A antibodies was performed using a com-mercial ELISA. Anti-cN1A antibodies were detected in 23 s-IBM patients, resulting in a sensitivity of 37.1% with a specificity of 96.8%. Positive and negative predictive values were 92.0% and 60.6%, respectively. We did not find significant difference regarding demographic variables, nor quadriceps or finger flexor weakness. Nevertheless, we found that anti-cN1A-positive patients presented significantly lower scores in IBMFRS item 1 (swallowing, p = 0.045) and more frequently reported more severe swallowing problems, expressed as an IBMFRS item 1 score ≤ 2 (p < 0.001). We confirmed the low sensitivity and high specificity of anti-cN1A Ab in s-IBM patients with a high positive predictive value. The presence of anti-CN1A antibodies identified patients with a greater risk of more severe dysphagia.
2021
Anti-cN1A antibodies are associated with more severe dysphagia in sporadic inclusion body myositis / Lucchini M.; Maggi L.; Pegoraro E.; Filosto M.; Rodolico C.; Antonini G.; Garibaldi M.; Valentino M.L.; Siciliano G.; Tasca G.; De Arcangelis V.; De Fino C.; Mirabella M.. - In: CELLS. - ISSN 2073-4409. - ELETTRONICO. - 10:5(2021), pp. 1146.1146-1146.1146. [10.3390/cells10051146]
Lucchini M.; Maggi L.; Pegoraro E.; Filosto M.; Rodolico C.; Antonini G.; Garibaldi M.; Valentino M.L.; Siciliano G.; Tasca G.; De Arcangelis V.; De Fino C.; Mirabella M.
File in questo prodotto:
File Dimensione Formato  
cells-10-01146.pdf

accesso aperto

Tipo: Versione (PDF) editoriale
Licenza: Licenza per Accesso Aperto. Creative Commons Attribuzione (CCBY)
Dimensione 253.57 kB
Formato Adobe PDF
253.57 kB Adobe PDF Visualizza/Apri

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11585/861807
Citazioni
  • ???jsp.display-item.citation.pmc??? 3
  • Scopus 21
  • ???jsp.display-item.citation.isi??? 20
social impact