We describe the first case of hyperacute reversible encephalopathy following COVID-19 vaccination. A patient presented with acute onset encephalopathy, mainly characterized by agitation and confusion, rapidly responsive to high dosage steroid therapy and complete remission within 3 days from onset. The clinical manifestation was related with systemic and CSF cytokine hyperproduction, responsive to steroid therapy. Although the occurrence of encephalopathy after vaccination may be just a casual temporal association, we speculate that the cytokine-storm could be the result of an excessive innate immune response against the vaccine, in a predisposed patient susceptible to autoimmunity.
Baldelli L., Amore G., Montini A., Panzera I., Rossi S., Cortelli P., et al. (2021). Hyperacute reversible encephalopathy related to cytokine storm following COVID-19 vaccine. JOURNAL OF NEUROIMMUNOLOGY, 358, 577661-577661 [10.1016/j.jneuroim.2021.577661].
Hyperacute reversible encephalopathy related to cytokine storm following COVID-19 vaccine
Baldelli L.;Amore G.;Montini A.;Rossi S.;Cortelli P.;
2021
Abstract
We describe the first case of hyperacute reversible encephalopathy following COVID-19 vaccination. A patient presented with acute onset encephalopathy, mainly characterized by agitation and confusion, rapidly responsive to high dosage steroid therapy and complete remission within 3 days from onset. The clinical manifestation was related with systemic and CSF cytokine hyperproduction, responsive to steroid therapy. Although the occurrence of encephalopathy after vaccination may be just a casual temporal association, we speculate that the cytokine-storm could be the result of an excessive innate immune response against the vaccine, in a predisposed patient susceptible to autoimmunity.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
