We describe the first case of hyperacute reversible encephalopathy following COVID-19 vaccination. A patient presented with acute onset encephalopathy, mainly characterized by agitation and confusion, rapidly responsive to high dosage steroid therapy and complete remission within 3 days from onset. The clinical manifestation was related with systemic and CSF cytokine hyperproduction, responsive to steroid therapy. Although the occurrence of encephalopathy after vaccination may be just a casual temporal association, we speculate that the cytokine-storm could be the result of an excessive innate immune response against the vaccine, in a predisposed patient susceptible to autoimmunity.

Hyperacute reversible encephalopathy related to cytokine storm following COVID-19 vaccine

Baldelli L.;Amore G.;Montini A.;Rossi S.;Cortelli P.;
2021

Abstract

We describe the first case of hyperacute reversible encephalopathy following COVID-19 vaccination. A patient presented with acute onset encephalopathy, mainly characterized by agitation and confusion, rapidly responsive to high dosage steroid therapy and complete remission within 3 days from onset. The clinical manifestation was related with systemic and CSF cytokine hyperproduction, responsive to steroid therapy. Although the occurrence of encephalopathy after vaccination may be just a casual temporal association, we speculate that the cytokine-storm could be the result of an excessive innate immune response against the vaccine, in a predisposed patient susceptible to autoimmunity.
JOURNAL OF NEUROIMMUNOLOGY
Baldelli L.; Amore G.; Montini A.; Panzera I.; Rossi S.; Cortelli P.; Guarino M.; Rinaldi R.; D'Angelo R.
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11585/858931
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