In this paper, the applications, impact, and development of green cross-coupling reactions in academia and industry are discussed. Specifically, we discuss the translation of the Twelve Principles of Green Chemistry and their applications in pharmaceutical organometallic chemistry to stimulate the development of cost-effective and sustainable catalytic processes for the synthesis of active pharmaceutical ingredients (API). The evolution of the process for the synthesis of 3-ethylnyl aniline, a key intermediate for the synthesis of the tyrosine kinase inhibitor erlotinib, was described as an example of the application of this translation guide.

A translation of the twelve principles of green chemistry to guide the development of cross-coupling reactions

T. Fantoni
Primo
Investigation
;
A. Tolomelli
Secondo
Conceptualization
;
W. Cabri
Ultimo
Conceptualization
2022

Abstract

In this paper, the applications, impact, and development of green cross-coupling reactions in academia and industry are discussed. Specifically, we discuss the translation of the Twelve Principles of Green Chemistry and their applications in pharmaceutical organometallic chemistry to stimulate the development of cost-effective and sustainable catalytic processes for the synthesis of active pharmaceutical ingredients (API). The evolution of the process for the synthesis of 3-ethylnyl aniline, a key intermediate for the synthesis of the tyrosine kinase inhibitor erlotinib, was described as an example of the application of this translation guide.
T. Fantoni, A. Tolomelli, W. Cabri
File in questo prodotto:
Eventuali allegati, non sono esposti

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11585/853030
 Attenzione

Attenzione! I dati visualizzati non sono stati sottoposti a validazione da parte dell'ateneo

Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus 4
  • ???jsp.display-item.citation.isi??? 2
social impact