Neuroimaging is the growing area of neuroscience devoted to produce data with the goal of capturing processes and dynamics of the human brain. We consider the problem of inferring the brain connectivity network from time- dependent functional magnetic resonance imaging (fMRI) scans. To this aim we propose the symmetric graphical lasso, a penalized likelihood method with a fused type penalty function that takes into explicit account the natural symmetrical structure of the brain. Symmetric graphical lasso allows one to learn simultaneously both the network structure and a set of symmetries across the two hemispheres. We implement an alternating directions method of multipliers algorithm to solve the corresponding convex optimization problem. Furthermore, we apply our methods to estimate the brain networks of two subjects, one healthy and one affected by mental disorder, and to compare them with respect to their symmetric structure. The method applies once the temporal dependence characterizing fMRI data have been accounted for and we compare the impact on the analysis of different detrending techniques on the estimated brain networks. Although we focus on brain networks, symmetric graphical lasso is a tool which can be more generally applied to learn multiple networks in a context of dependent samples.

Fused graphical lasso for brain networks with symmetries

Ranciati, Saverio
Primo
;
Roverato, Alberto
Secondo
;
Luati, Alessandra
Ultimo
2021

Abstract

Neuroimaging is the growing area of neuroscience devoted to produce data with the goal of capturing processes and dynamics of the human brain. We consider the problem of inferring the brain connectivity network from time- dependent functional magnetic resonance imaging (fMRI) scans. To this aim we propose the symmetric graphical lasso, a penalized likelihood method with a fused type penalty function that takes into explicit account the natural symmetrical structure of the brain. Symmetric graphical lasso allows one to learn simultaneously both the network structure and a set of symmetries across the two hemispheres. We implement an alternating directions method of multipliers algorithm to solve the corresponding convex optimization problem. Furthermore, we apply our methods to estimate the brain networks of two subjects, one healthy and one affected by mental disorder, and to compare them with respect to their symmetric structure. The method applies once the temporal dependence characterizing fMRI data have been accounted for and we compare the impact on the analysis of different detrending techniques on the estimated brain networks. Although we focus on brain networks, symmetric graphical lasso is a tool which can be more generally applied to learn multiple networks in a context of dependent samples.
Ranciati, Saverio; Roverato, Alberto; Luati, Alessandra
File in questo prodotto:
Eventuali allegati, non sono esposti

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11585/829652
 Attenzione

Attenzione! I dati visualizzati non sono stati sottoposti a validazione da parte dell'ateneo

Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus 0
  • ???jsp.display-item.citation.isi??? 1
social impact