The authors report the case of a 71-year-old woman presented to the Emergency Department with acute ischemic stroke. She was treated with rt-PA and interventional endovascular revascularization and developed rapidly progressing angioedema that led to emergency intubation. The standard treatment was not very effective and the swelling improved after infusion of fresh frozen plasma. Angioedema after rt-PA infusion could be a life-threatening emergency that requires quick airway management by skilled professionals. As this condition is triggered by several factors, such as unregulated histamine and bradykinin production, the traditional treatment recommended by the guidelines may not be sufficient and the use of FFP can be considered as a safe and valuable aid.

Carlo Alberto Mazzoli, M.I.D. (2023). Angioedema after rt-PA infusion led to airwayemergency: a case report of rescue treatment withfresh frozen plasma. BRAZILIAN JOURNAL OF ANESTHESIOLOGY, 73(2), 223-226 [10.1016/j.bjane.2021.04.023].

Angioedema after rt-PA infusion led to airwayemergency: a case report of rescue treatment withfresh frozen plasma

Luigi Cirillo;
2023

Abstract

The authors report the case of a 71-year-old woman presented to the Emergency Department with acute ischemic stroke. She was treated with rt-PA and interventional endovascular revascularization and developed rapidly progressing angioedema that led to emergency intubation. The standard treatment was not very effective and the swelling improved after infusion of fresh frozen plasma. Angioedema after rt-PA infusion could be a life-threatening emergency that requires quick airway management by skilled professionals. As this condition is triggered by several factors, such as unregulated histamine and bradykinin production, the traditional treatment recommended by the guidelines may not be sufficient and the use of FFP can be considered as a safe and valuable aid.
2023
Carlo Alberto Mazzoli, M.I.D. (2023). Angioedema after rt-PA infusion led to airwayemergency: a case report of rescue treatment withfresh frozen plasma. BRAZILIAN JOURNAL OF ANESTHESIOLOGY, 73(2), 223-226 [10.1016/j.bjane.2021.04.023].
Carlo Alberto Mazzoli, Maura Ida D’Angelo, Luigi Simonetti, Luigi Cirillo, Andrea Zini, Mauro Gentile, Giovanni Gordini, Carlo Coniglio
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11585/828665
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